Results 101 to 110 of about 252,954 (227)

Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5

MedComm, Volume 7, Issue 6, June 2026.
The seasonal human coronaviruses 229E and OC43 are common causes of mild respiratory infections but can cause severe disease in vulnerable individuals. Serine incorporator 5 (SERINC5) efficiently inhibits OC43, while hCoV‐229E uses its ORF4/4a accessory proteins to efficiently counteract this restriction by promoting relocalization of SERINC5 to ...
Qinya Xie, Sabrina Noettger, Jan Lawrenz, Sophie Stopper, Susanne Klute, Jan Münch, Dorota Kmiec, Qingxing Wang, Konstantin M. J. Sparrer, Frank Kirchhoff   +9 more
wiley   +1 more source

MERS-CoV: An Epidemic Whirlwind

Biology and Medicine, 2016
Corona virus as a Middle East Respiratory Syndrome (MERS) considered being a new complicated disease; it infects the epithelial cells in the respiratory and/or intestinal tracts, thus causing disease in epidemic proportions. The situation is exacerbated by either a short incubation period between 2-7 days or between 12-14 days.
Ilham Qattan, Aljohani A
openaire   +1 more source

Phylogenetic analysis of SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) based on Neighbor-Joining method.

, 2022
SARS-CoV and MERS-CoV highly pathogenic beta coronaviruses along with SARS-like bat coronaviruses closely linked to SARS-CoV-2. Number at nodes indicates support for bootstrap (100 replicates), and the bar of scale indicates the average number of ...
Md. Samiul Islam (12368722), Md. Shahin Sarker (12368719), Md. Nurul Haque Mollah (8946176), Sohel Hasan (12368725), Fee Faysal Ahmed (9904603), Md. Parvez Mosharaf (9904597), Md. Selim Reza (12368716)   +6 more
core   +1 more source

MERS-CoV antibody responses 1 year after symptom onset, South Korea, 2015

, 2017
MERS-CoV antibody responses 1 year after symptom onset, South Korea ...
KH Song (16545564), WB Park (16545561), LWR Ko (16545567), JH Bang (16193105), NJ Kim (12137475), ES Kim (15766910), M Peiris (13321764), MD Oh (16545573), Eric Lau (15903800), SW Park (16545570), PG Choe (16545558), RAPM Perera (16545465), LLM Poon (16544559), HB Kim (14546711)   +13 more
core   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

First international external quality assessment of molecular diagnostics for Mers-CoV [PDF]

, 2015
BACKGROUND: Since the discovery of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, diagnostic protocols were quickly published and deployed globally.
Drosten, Christian, Dijkman, Ronald, Pas, Suzan D., Corman, Victor M., Koopmans, Marion P.G., Domingo, Cristina, Nowotny, Norbert, Thiel, Volker Earl, Patel, Pranav, Thiel, Volker, Niedrig, Matthias, Reusken, Chantal   +11 more
core   +1 more source

Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

Cell Reports, 2019
Summary: Middle East respiratory syndrome coronavirus (MERS-CoV) emerged into the human population in 2012 and has caused substantial morbidity and mortality. Potently neutralizing antibodies targeting the receptor-binding domain (RBD) on MERS-CoV spike (
Nianshuang Wang, Osnat Rosen, Lingshu Wang, Hannah L. Turner, Laura J. Stevens, Kizzmekia S. Corbett, Charles A. Bowman, Jesper Pallesen, Wei Shi, Yi Zhang, Kwanyee Leung, Robert N. Kirchdoerfer, Michelle M. Becker, Mark R. Denison, James D. Chappell, Andrew B. Ward, Barney S. Graham, Jason S. McLellan   +17 more
doaj   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Sola Akinbolade, Rhiannon Potter, Alex Inskip, Jane Nesworthy, Kirsti Brock, Gill Norman   +5 more
wiley   +1 more source

Data_Sheet_1_Comparative transcriptome analysis of SARS-CoV-2, SARS-CoV, MERS-CoV, and HCoV-229E identifying potential IFN/ISGs targets for inhibiting virus replication.docx

, 2023
IntroductionSince its outbreak in December 2019, SARS-CoV-2 has spread rapidly across the world, posing significant threats and challenges to global public health.
Tianyi Lu (2812831), Chunlai Jiang (203935), Fei Chen (13690), Yuzhuang Liu (17602935), Liya Yue (5640293), Cuidan Li (5640287), Xiaotong Wang (276499)   +6 more
core   +1 more source

MERS-CoV: in search of answers [PDF]

The Lancet, 2013
Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been a cause for concern for months, with a steady trickle of new cases, often fatal, dating back to April, 2012. Until March of this year there were fewer than fi ve confi rmed infections per month, but April and May each saw 19 new cases, driven up by a cluster in the Al-Ahsa region in ...
openaire   +1 more source