Results 171 to 180 of about 204,592 (304)

Superior Mesenteric Artery Syndrome

open access: yesGastro Hep Advances, 2022
Kwabena Oware Adu-Gyamfi   +2 more
openaire   +3 more sources

VEGF inhibitor‐induced vascular dysfunction involves redox‐sensitive PARP activation and SIRT1 disruption

open access: yesExperimental Physiology, EarlyView.
Abstract Vascular endothelial growth factor receptor (VEGFR) inhibitors are effective antiangiogenic agents used in cancer therapy. However, they are associated with cardiovascular disease, including hypertension and vascular dysfunction. The molecular mechanisms underlying these cardiovascular toxicities are unclear, but oxidative stress might be ...
Karla B. Neves   +3 more
wiley   +1 more source

Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring

open access: yesExperimental Physiology, EarlyView.
Abstract Maternal obesity is a major public health concern, with growing evidence supporting its role in the developmental programming of cardiometabolic disease. Although prenatal mechanisms have been investigated extensively, the contribution of lactation as a postnatal window of cardiovascular (CV) programming remains insufficiently understood ...
Gabriela Arenas   +2 more
wiley   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Characterization of adrenergic and purinergic contractile responses in rat mesenteric arteries and veins

open access: yes, 2008
Norepinephrine (NE) and adenosine 5’-triphosphate (ATP) are neurotransmitters released from sympathetic neurons that act to alter net vascular tone in the mesentery via activation of adrenergic (α1 and α2) and purinergic (P2X and P2Y) receptors.
Ludwig, Nathan, Carter, Rebekah
core  

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor   +5 more
wiley   +1 more source

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