Results 61 to 70 of about 5,478,967 (327)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Multi-population genetic algorithms with immigrants scheme for dynamic shortest path routing problems in mobile ad hoc networks [PDF]
, 2010 Copyright @ Springer-Verlag Berlin Heidelberg 2010.The static shortest path (SP) problem has been well addressed using intelligent optimization techniques, e.g., artificial neural networks, genetic algorithms (GAs), particle swarm optimization, etc ...
A.W. Mohemmed +9 more
core +4 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
EntropyImage stitching aims to synthesize a wider and more informative whole image, which has been widely used in various fields. This study focuses on improving the accuracy of image mosaic and proposes an image mosaic method based on local edge contour ...
Shaokang Ma +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Real-Valued Optical Matrix Computing with Simplified MZI Mesh
Intelligent Computing, 2023 The Mach–Zehnder interferometer (MZI) mesh, a mainstream structure for optical matrix-vector multiplication (MVM), has been widely employed in recently developed optical neural networks (ONNs) and combination optimization problem solvers.
Bo Wu +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Engineering ProceedingsThis paper presents the documentation, study activities, and possible applications of 3D digital models for the analysis and reconstruction of some examples of spheroidal stone projectiles—launched during the Sullan siege in 89 BC—now preserved in the ...
Silvia Bertacchi
doaj +1 more source
Journal of Approximation Theory, 2011 Let \(P^d_n\) be the space of real algebraic polynomials of \(d\) variables and degree at most \(n\), \(K\subset {\mathbb R}^d\) a compact set, \(\| p \|_K:=\sup_{x \in K} |p(x)|\) the usual supremum norm on \(K\), and \(\text{card}(Y)\) the cardinality of a finite set \(Y\).
openaire +2 more sources
Online Mesh Optimization for Large Scale KinectFusion Meshes
IFAC-PapersOnLine, 2016 Abstract In this paper we present an extension of Large Scale Kinect Fusion to compute optimized triangle meshes on-the-fly by removing redundant triangles on planar surfaces. The optimization is integrated into the reconstruction pipeline to compute the optimized meshes asynchronously to the reconstruction process in real time.
Tristan Igelbrink +2 more
openaire +1 more source