Results 31 to 40 of about 30,812 (258)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Evaluating Hex-mesh Quality Metrics via Correlation Analysis
, 2017 Hexahedral (hex-) meshes are important for solving partial differential equations (PDEs) in applications of scientific computing and mechanical engineering. Many methods have been proposed aiming to generate hex-meshes with high scaled Jacobians.
Huang, Jin +5 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Multi-Resolution Texture Coding for Multi-Resolution 3D Meshes
, 2011 We present an innovative system to encode and transmit textured multi-resolution 3D meshes in a progressive way, with no need to send several texture images, one for each mesh LOD (Level Of Detail).
Rafael Pages Scasso +5 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A survey of routing metrics in cluster-based routing protocols for wireless mesh networks [PDF]
, 2011 Routing metrics that will strike a balanced tradeoff between low computational overheads and high throughput, low delay, load balancing and low interference still remain a greater challenge to researchers in wireless networks.
Adekiigbe, Adebanjo +2 more
core
Discrete Differential Operators for Computer Graphics [PDF]
, 2004 This thesis presents a family of discrete differential operators. Since these operators are derived taking into account the continuous notions of differential geometry, they possess many similar properties.
Meyer, Mark
core +1 more source
The modified metric for self-organization wireless MESH networks
ITM Web of Conferences, 2018 This paper concerns the modified metrics for MESH wireless networks. This metric is important when a specific data transmission path is being chosen. The parameters regarding the connection quality and overload are introduced in it.
Paszkiewicz Andrzej, Zapała Przemysław
doaj +1 more source
METRICS FOR IMAGE SURFACE APPROXIMATION BASED ON TRIANGULAR MESHES
Image Analysis and Stereology, 2018 Surface approximation plays an important role in several application fields, such as computer-aided design, computer graphics, remote sensing, computer vision, robotics, architecture, and manufacturing.
Eduardo Sant'Ana da Silva +2 more
doaj +1 more source
Tumor Treating Fields for Ovarian Carcinoma: A Modeling Study
Advances in Radiation Oncology, 2021 Purpose: Since the inception of tumor treating fields (TTFields) therapy as a Food and Drug Administration–approved treatment with known clinical efficacy against recurrent and newly diagnosed glioblastoma, various in silico modeling studies have been ...
Edwin Lok, MS +6 more
doaj +1 more source