Results 41 to 50 of about 27,088 (253)

Using plant litter decomposition as an indicator of ecosystem response to soil contamination

open access: yesEcological Indicators, 2021
The inventory and remediation of contaminated sites have emerged as top environmental priorities worldwide. A large body of evidence has accumulated to show how soil contamination affects biological communities and ecological processes.
Antoine Lecerf   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The modified metric for self-organization wireless MESH networks

open access: yesITM Web of Conferences, 2018
This paper concerns the modified metrics for MESH wireless networks. This metric is important when a specific data transmission path is being chosen. The parameters regarding the connection quality and overload are introduced in it.
Paszkiewicz Andrzej, Zapała Przemysław
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Towards a functional assessment of stream integrity: A first large-scale application using leaf litter decomposition

open access: yesEcological Indicators, 2022
There is increasing recognition that indicators of ecosystem functioning are needed to improve current stream monitoring schemes. However, to date, no attempt has been made to include functional metrics in large-scale routine monitoring programs under ...
Magali Brosed   +2 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Joint Optimization-Based Texture and Geometry Enhancement Method for Single-Image-Based 3D Content Creation

open access: yesMathematics
Recent studies have explored the generation of three-dimensional (3D) meshes from single images. A key challenge in this area is the difficulty of improving both the generalization and detail simultaneously in 3D mesh generation.
Jisun Park   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Análisis de eficiencia de protocolos de enrutamiento en implementación de Red Inalámbrica Mesh en instalaciones de la Facultad de Ingeniería en Electricidad y Computación (FIEC) realizando llamadas de Voz sobre IP

open access: yesRevista Tecnológica, 2012
Las redes inalámbricas malladas, debido a sus ventajas, ofrecen una opción muy interesante al momento de diseñar una  red inalámbrica, y la investigación sobre ellas cada día se extiende más. No obstante, uno de los principales retos en la investigación
E. Jiménez   +3 more
doaj   +4 more sources

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