Results 51 to 60 of about 56,264 (303)

Issues in adaptive mesh refinement [PDF]

2010 IEEE International Symposium on Parallel & Distributed Processing, Workshops and Phd Forum (IPDPSW), 2010
In this paper, we present an approach for a patch-based adaptive mesh refinement (AMR) for multi-physics simulations. The approach consists of clustering, symmetry preserving, mesh continuity, flux correction, communications, management of patches, and dynamical load balance.
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An Adaptive h-Refinement Algorithm for Local Damage Models

Algorithms, 2009
An adaptive mesh refinement strategy is proposed for local damage models that often arise from internal state variable based continuum damage models.
Francesco Costanzo, Jonathan S. Pitt
doaj   +1 more source

Validation for CFD Simulation in Rod Bundles With Split-Vane Spacer Grids Based on LDA Measurement

Frontiers in Energy Research, 2020
Laser Doppler anemometry (LDA) measurement of axial flow velocity and pressure drop measurement has been carried out in a 5 × 5 rod bundle installed with two split-mixing-vane grids. The measured results are utilized to validate the CFD simulation.
Jinbiao Xiong, Chuan Lu, Wenhai Qu
doaj   +1 more source

Thickness-based adaptive mesh refinement methods for multi-phase flow simulations with thin regions

, 2014
In numerical simulations of multi-scale, multi-phase flows, grid refinement is required to resolve regions with small scales. A notable example is liquid-jet atomization and subsequent droplet dynamics.
Chen XD(陈晓东), Yang V, Yang, V
core   +1 more source

Curved Domain Adaptive Mesh Refinement with Hexahedra [PDF]

, 2021
In tree-based adaptive mesh refinement (AMR) we store refinement trees in the cells of an unstructured coarse mesh. This lets us combine the speed and simpler management of structured refinement trees with the more flexible mesh generation of the ...
Elsweijer, Sandro
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Swarm Reinforcement Learning For Adaptive Mesh Refinement

, 2023
Adaptive Mesh Refinement (AMR) enhances the Finite Element Method, an important technique for simulating complex problems in engineering, by dynamically refining mesh regions, enabling a favorable trade-off between computational speed and simulation ...
Kärger, Luise, Dahlinger, Philipp, Würth, Tobias, Neumann, Gerhard, Reisch, Simon, Freymuth, Niklas   +5 more
core   +3 more sources