Results 1 to 10 of about 403,754 (120)

The KIR repertoire of a West African chimpanzee population is characterized by limited gene, allele, and haplotype variation

open access: yesFrontiers in Immunology, 2023
IntroductionThe killer cell immunoglobulin-like receptors (KIR) play a pivotal role in modulating the NK cell responses, for instance, through interaction with major histocompatibility complex (MHC) class I molecules.
Natasja G. de Groot   +5 more
doaj   +1 more source

The Genomic Organization of the LILR Region Remained Largely Conserved Throughout Primate Evolution: Implications for Health And Disease

open access: yesFrontiers in Immunology, 2021
The genes of the leukocyte immunoglobulin-like receptor (LILR) family map to the leukocyte receptor complex (LRC) on chromosome 19, and consist of both activating and inhibiting entities. These receptors are often involved in regulating immune responses,
Lisanne Storm   +4 more
doaj   +1 more source

Rapid Characterization of Complex Killer Cell Immunoglobulin-Like Receptor (KIR) Regions Using Cas9 Enrichment and Nanopore Sequencing

open access: yesFrontiers in Immunology, 2021
Long-read sequencing approaches have considerably improved the quality and contiguity of genome assemblies. Such platforms bear the potential to resolve even extremely complex regions, such as multigenic immune families and repetitive stretches of DNA ...
Jesse Bruijnesteijn   +4 more
doaj   +1 more source

Surgical or Nonsurgical Facial Rejuvenation: The Patients’ Choice

open access: yesPlastic and Reconstructive Surgery, Global Open, 2023
Background:. Patients seeking a pan-facial rejuvenation may not receive appropriate medical advice on surgical versus nonsurgical treatments, resulting in those who are best-suited for surgery receiving nonsurgical options, and vice versa.
Niamh Corduff, MBBS
doaj   +1 more source

Neuromodulating the SMAS for Natural Dynamic Results

open access: yesPlastic and Reconstructive Surgery, Global Open, 2021
Summary:. Physicians using neuromodulators need to develop an in-depth and holistic understanding of the facial musculature as a single, large, functional structure that does not work in isolation.
Niamh Corduff, MBBS, FRACS
doaj   +1 more source

Sensory Symptoms Associated with Aesthetic Botulinum Toxin A Treatments

open access: yesPlastic and Reconstructive Surgery, Global Open, 2022
Background:. A retrospective review of patients who switched from onabotulinumtoxinA (onaA) and/or abobotulinumtoxinA (aboA) to incobotulinumtoxinA (incoA) found anecdotal reports of differences in “feel,” including a “lighter” feel or treatment ...
Niamh Corduff, MBBS, FRACS
doaj   +1 more source

The Genetic Mechanisms Driving Diversification of the KIR Gene Cluster in Primates

open access: yesFrontiers in Immunology, 2020
The activity and function of natural killer (NK) cells are modulated through the interactions of multiple receptor families, of which some recognize MHC class I molecules.
Jesse Bruijnesteijn   +3 more
doaj   +1 more source

Refining Procedures within Regulatory Toxicology Studies: Improving Animal Welfare and Data

open access: yesAnimals, 2021
During the development of potential new medicines or agrochemicals, an assessment of the safety profile to humans and environmental species is conducted using a range of different in silico and in vitro techniques in conjunction with metabolism and ...
Helen Prior   +5 more
doaj   +1 more source

Improved Training and Semen Collection Outcomes Using the Closed Box Chair for Macaques

open access: yesAnimals, 2021
Collaborative semen collection in monkeys is a valuable tool in research, animal collection management, and conservation efforts. To obtain samples, monkeys are often restrained in open restraint chairs (ORC) with the “pole and collar” technique.
Lisa A. Houser   +6 more
doaj   +1 more source

Why workshops work: Examining the efficacy of training trainers to train goats

open access: yesAnimal Welfare, 2023
Experimental procedures involving farm animals are often associated with stress due to restraining. Stress can be reduced through use of positive reinforcement training, which then serves as refinement according to the 3Rs principles.
Jennifer Meier   +4 more
doaj   +1 more source

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