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IntroductionThe killer cell immunoglobulin-like receptors (KIR) play a pivotal role in modulating the NK cell responses, for instance, through interaction with major histocompatibility complex (MHC) class I molecules.
Natasja G. de Groot +5 more
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Long-read sequencing approaches have considerably improved the quality and contiguity of genome assemblies. Such platforms bear the potential to resolve even extremely complex regions, such as multigenic immune families and repetitive stretches of DNA ...
Jesse Bruijnesteijn +4 more
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The genes of the leukocyte immunoglobulin-like receptor (LILR) family map to the leukocyte receptor complex (LRC) on chromosome 19, and consist of both activating and inhibiting entities. These receptors are often involved in regulating immune responses,
Lisanne Storm +4 more
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Sensory Symptoms Associated with Aesthetic Botulinum Toxin A Treatments
Background:. A retrospective review of patients who switched from onabotulinumtoxinA (onaA) and/or abobotulinumtoxinA (aboA) to incobotulinumtoxinA (incoA) found anecdotal reports of differences in “feel,” including a “lighter” feel or treatment ...
Niamh Corduff, MBBS, FRACS
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Surgical or Nonsurgical Facial Rejuvenation: The Patients’ Choice
Background:. Patients seeking a pan-facial rejuvenation may not receive appropriate medical advice on surgical versus nonsurgical treatments, resulting in those who are best-suited for surgery receiving nonsurgical options, and vice versa.
Niamh Corduff, MBBS
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Neuromodulating the SMAS for Natural Dynamic Results
Summary:. Physicians using neuromodulators need to develop an in-depth and holistic understanding of the facial musculature as a single, large, functional structure that does not work in isolation.
Niamh Corduff, MBBS, FRACS
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The ultimate goal of the Three Rs is the full replacement of animals used in biomedical research and testing. However, replacement is unlikely to occur in the near future; therefore the scientific community as a whole must continue to devote considerable effort to ensure optimal animal welfare for the benefit of the science and the animals, i.e., the R
Joanne, Zurlo, Eric, Hutchinson
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Refining Procedures within Regulatory Toxicology Studies: Improving Animal Welfare and Data
During the development of potential new medicines or agrochemicals, an assessment of the safety profile to humans and environmental species is conducted using a range of different in silico and in vitro techniques in conjunction with metabolism and ...
Helen Prior +5 more
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The Genetic Mechanisms Driving Diversification of the KIR Gene Cluster in Primates
The activity and function of natural killer (NK) cells are modulated through the interactions of multiple receptor families, of which some recognize MHC class I molecules.
Jesse Bruijnesteijn +3 more
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We study mesh refinement techniques for first-order hyperbolic equations. A refinement method for use with the leap-frog scheme is defined and its stability established. The remainder of the paper is devoted to a discussion of the effects of nonuniform grids and the circumstances under which they may be used.
Browning, Gerald +2 more
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