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IntroductionThe killer cell immunoglobulin-like receptors (KIR) play a pivotal role in modulating the NK cell responses, for instance, through interaction with major histocompatibility complex (MHC) class I molecules.
Natasja G. de Groot +5 more
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The genes of the leukocyte immunoglobulin-like receptor (LILR) family map to the leukocyte receptor complex (LRC) on chromosome 19, and consist of both activating and inhibiting entities. These receptors are often involved in regulating immune responses,
Lisanne Storm +4 more
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Long-read sequencing approaches have considerably improved the quality and contiguity of genome assemblies. Such platforms bear the potential to resolve even extremely complex regions, such as multigenic immune families and repetitive stretches of DNA ...
Jesse Bruijnesteijn +4 more
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Surgical or Nonsurgical Facial Rejuvenation: The Patients’ Choice
Background:. Patients seeking a pan-facial rejuvenation may not receive appropriate medical advice on surgical versus nonsurgical treatments, resulting in those who are best-suited for surgery receiving nonsurgical options, and vice versa.
Niamh Corduff, MBBS
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Neuromodulating the SMAS for Natural Dynamic Results
Summary:. Physicians using neuromodulators need to develop an in-depth and holistic understanding of the facial musculature as a single, large, functional structure that does not work in isolation.
Niamh Corduff, MBBS, FRACS
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Sensory Symptoms Associated with Aesthetic Botulinum Toxin A Treatments
Background:. A retrospective review of patients who switched from onabotulinumtoxinA (onaA) and/or abobotulinumtoxinA (aboA) to incobotulinumtoxinA (incoA) found anecdotal reports of differences in “feel,” including a “lighter” feel or treatment ...
Niamh Corduff, MBBS, FRACS
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The Genetic Mechanisms Driving Diversification of the KIR Gene Cluster in Primates
The activity and function of natural killer (NK) cells are modulated through the interactions of multiple receptor families, of which some recognize MHC class I molecules.
Jesse Bruijnesteijn +3 more
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Refining Procedures within Regulatory Toxicology Studies: Improving Animal Welfare and Data
During the development of potential new medicines or agrochemicals, an assessment of the safety profile to humans and environmental species is conducted using a range of different in silico and in vitro techniques in conjunction with metabolism and ...
Helen Prior +5 more
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Improved Training and Semen Collection Outcomes Using the Closed Box Chair for Macaques
Collaborative semen collection in monkeys is a valuable tool in research, animal collection management, and conservation efforts. To obtain samples, monkeys are often restrained in open restraint chairs (ORC) with the “pole and collar” technique.
Lisa A. Houser +6 more
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Why workshops work: Examining the efficacy of training trainers to train goats
Experimental procedures involving farm animals are often associated with stress due to restraining. Stress can be reduced through use of positive reinforcement training, which then serves as refinement according to the 3Rs principles.
Jennifer Meier +4 more
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