Results 1 to 10 of about 21,873 (185)

Linkage disequilibrium organization of the human KIR superlocus: implications for KIR data analyses [PDF]

Immunogenetics, 2010
An extensive family-based study of linkage disequilibrium (LD) in the killer cell immunoglobulin-like receptors (KIR) cluster was performed. We aimed to describe the LD structure in the KIR gene cluster using a sample of 418 founder haplotypes identified by segregation in a group of 106 families from Northern Ireland.
Pierre-Antoine Gourraud, Ashley Meenagh, Anne Cambon-Thomsen   +2 more
exaly   +6 more sources

Autologous and allogeneic HLA KIR ligand environments and activating KIR control KIR NK‐cell functions [PDF]

European Journal of Immunology, 2008
AbstractNK‐cell function is regulated by a balance between inhibitory and activating killer cell immunoglobulin‐like receptors (KIR) that specifically recognize HLA class I molecules. Using KIR‐specific mAb to discriminate between KIR2DS1 and KIR2DL1 receptors, we show that KIR2DS1+ NK cells are C2‐alloreactive only from C2− individuals.
Morvan, Maelig, David, Gaëlle, Sébille, Véronique, Perrin, Aurore, Gagne, Katia, Willem, Catherine, Kerdudou, Nolwenn, Denis, Laure, Clémenceau, Béatrice, Folléa, Gilles, Bignon, Jean-Denis, Retiere, Christelle   +11 more
openaire   +3 more sources

Molecular determinant-based typing of KIR alleles and KIR ligands [PDF]

Clinical Immunology, 2011
Killer cell immunoglobulin-like receptors (KIRs) regulate NK cell function. KIRs and their HLA ligands are highly polymorphic in nature with substantial allelic polymorphism. At present, there is a lack of an expedient method for KIR and HLA allele typing with relevant functional information.
Rafijul, Bari, Matthias, Leung, Victoria E, Turner, Christy, Embrey, Barbara, Rooney, Martha, Holladay, Wing, Leung   +6 more
openaire   +2 more sources

Impulse Configuration in Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea: The Effect of Modifying Pulse Width and Frequency

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Hypoglossal nerve stimulation is an effective treatment option for obstructive sleep apnea (OSA) in positive airway pressure therapy failure. Nonetheless, data regarding the functional effect of modifying stimulation parameters within each electrode configuration are limited.
Armin Steffen, Stephanie Jeschke, Ryan J. Soose, Katrin Hasselbacher, Inke R. König   +4 more
wiley   +1 more source

Activating KIR: iN Kase of KIR-ligand mismatch [PDF]

Blood, 2015
In this issue of Blood, Mancusi et al demonstrate that haploidentical hematopoietic stem cell transplantation (HSCT) from killer immunoglobulin-like receptor (KIR) ligand–mismatched donors with concomitant activating KIRs reduces nonrelapse mortality (NRM ...
openaire   +2 more sources

Cholesterol and Kir channels [PDF]

IUBMB Life, 2009
AbstractTo date, most of the major types of Kir channels, Kir2s, Kir3s, Kir4s, and Kir6s, have been found to partition into cholesterol‐rich membrane domains and/or to be regulated by changes in the level of membrane cholesterol. Surprisingly, however, in spite of the structural similarities between different Kirs, effects of cholesterol on different ...
openaire   +2 more sources

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Effects of Early, High Moisture Harvesting on Grain, Milling, Flour, and Baking Quality of Six Winter Wheat Varieties

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives Three US soft wheat varieties (Hilliard, Wilson, and Kokosing), one Korean soft wheat variety (Olgeru), and two Korean hard wheat varieties (Keumkang and Sukang) were harvested three times on weekly intervals beginning at approximately 20% grain moisture, and were evaluated for grain, milling, flour quality, and ...
Prabath Senanayaka Mudiyanselage, Jinhee Park, Byung‐Kee Baik, Laura E. Lindsey   +3 more
wiley   +1 more source

Mature T‐cell leukemia/lymphoma with an NK‐like immunophenotype: A report of 7 cases

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Distinguishing T‐cell from NK‐cell neoplasms can occasionally be challenging, as neoplastic T cells can lose T‐cell markers such as surface CD3 (sCD3) and CD5 while acquiring NK‐cell markers such as CD16, CD56, and CD94. In this study, we present a series of 7 mature T‐cell lymphoma/leukemia cases with NK‐like immunophenotypes to clarify ...
Wei J. Wang, Sa A. Wang, Hong Fang, Jeffrey L. Jorgensen, Shimin Hu, Lianqun Qiu, Jie Xu, L. Jeffrey Medeiros, Wei Wang   +8 more
wiley   +1 more source

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source