Results 1 to 10 of about 38,491 (220)

KIR And HLA Haplotype Analysis in a Family Lacking The KIR 2DL1-2DP1 Genes [PDF]

Balkan Journal of Medical Genetics, 2015
The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity that is observed as presence/absence of genes, resulting in expansion and contraction of KIR haplotypes and by allelic variation of ...
Vojvodić Svetlana, Ademović-Sazdanić D.   +1 more
doaj   +4 more sources

Linkage disequilibrium organization of the human KIR superlocus: implications for KIR data analyses [PDF]

Immunogenetics, 2010
An extensive family-based study of linkage disequilibrium (LD) in the killer cell immunoglobulin-like receptors (KIR) cluster was performed. We aimed to describe the LD structure in the KIR gene cluster using a sample of 418 founder haplotypes identified by segregation in a group of 106 families from Northern Ireland.
Anne Cambon-Thomsen, Derek Middleton, Pierre-Antoine Gourraud   +2 more
exaly   +8 more sources

KIR genotype distribution among patients with multiple myeloma: Higher prevalence of KIR 2DS4 and KIR 2DS5 genes [PDF]

Meta Gene, 2014
Natural killer (NK) cells possess an antitumor activity against multiple myeloma cells proven by the susceptibility of plasmocytes to NK lysis. In the early stage of MM, the killing of MM cells is mediated by natural cytotoxicity receptors (NRC) and NKG2D-dependent pathway, while in the late stage, NK cells lose their killing potential against MM cells
Rami Mahfouz
exaly   +4 more sources

KIR AA individuals possess strong inhibitory KIR alleles alongside HLA ligands that are protective against leukemia in the Chinese population [PDF]

Frontiers in Genetics
IntroductionThe killer-cell immunoglobulin-like receptor (KIR) gene cluster exhibits complicated diversity in haplotype content, copy-number variation (CNV), and allelic polymorphism.
Zhihui Deng, Jianxin Zhen, Yunan Li, Shuang Liang, Manru Zhang, Siqi Cai, Renhui Jiang, Zhichao Yang, Qiong Yu, Jinyong Wang, Jinyong Wang, Jinyong Wang, Jie Liu   +12 more
doaj   +2 more sources

Killer-cell immunoglobulin-like receptors define a potent effector program in human γδ T cells [PDF]

JCI Insight
Human γδ T cells are a rare but functionally diverse lymphocyte subset critical for tumor surveillance and antimicrobial immunity. Although they express NK cell–associated receptors such as killer-cell immunoglobulin-like receptors (KIRs), the relevance ...
Mahya Razmi, Yeganeh Almasi, Marilee Larrivée, Jonathan B. Angel, Alexandre Blais, Zakia Djaoud   +5 more
doaj   +2 more sources

Кір [Kir]

, 2013
КІР – назва групи природних бітумів , що утворюються в результаті вивітрювання в зоні виходів легких метанових і нафтенових нафт. Залежно від складу та глибини вивітрювання нафт колір К. змінюється від темно-коричневого до чорного. Густина 0,96–1,2. Розчинний в орган. розчинниках ⚠️ Цей запис містить лише бібліографічні метадані.
  +12 more sources

De Novo Assembly of Plasmodium knowlesi Genomes From Clinical Samples Explains the Counterintuitive Intrachromosomal Organization of Variant SICAvar and kir Multiple Gene Family Members

Frontiers in Genetics, 2022
Plasmodium knowlesi, a malaria parasite of Old World macaque monkeys, is used extensively to model Plasmodium biology. Recently, P. knowlesi was found in the human population of Southeast Asia, particularly Malaysia. P.
Damilola R. Oresegun, Peter Thorpe, Ernest Diez Benavente, Susana Campino, Fauzi Muh, Robert William Moon, Taane Gregory Clark, Taane Gregory Clark, Janet Cox-Singh   +8 more
doaj   +1 more source

Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response

OncoImmunology, 2021
The antibody-dependent cellular cytotoxicity (ADCC) effector function of natural killer (NK) cells is one of the known mechanisms of action for rituximab-based anti-cancer immunotherapy.
Dhon Roméo Makanga, Maxime Jullien, Gaëlle David, Nolwenn Legrand, Catherine Willem, Léa Dubreuil, Alexandre Walencik, Cyrille Touzeau, Thomas Gastinne, Benoit Tessoulin, Steven Le Gouill, Béatrice Mahé, Katia Gagne, Patrice Chevallier, Béatrice Clemenceau, Christelle Retière   +15 more
doaj   +1 more source

Killer cell immunoglobulin-like receptor alleles influence susceptibility to occult hepatitis B infection in West African population

Journal of Public Health in Africa, 2023
Occult hepatitis B infection (OBI) is a public health problem in Burkina Faso. OBI represents a risk factor for the development of cirrhosis and hepatocellular carcinoma (HCC).
Momeiyi M. Bazie, Florencia W. Djigma, Mahamoudou Sanou, Pegdwendé A. Sorgho, Abdoul K. Ouattara, Dorcas Obiri-Yeboah, Nadege Kapieko, Herman K. Sombie, Prosper Bado, Edwige T. Yelemkoure, Isabelle T. Kiendrebeogo, Marius B. Nagalo, Albert T. Yonli, Jacques Simpore   +13 more
doaj   +1 more source

Study on relationship between platelet transfusion efficacy and KIR-HLA receptor-ligand compatibility

Zhongguo shuxue zazhi, 2023
Objective To study the correlation between platelet transfusion efficacy and KIR receptor-HLA ligand. Methods Thirty-three leukemia patients with positive HLA antibody were tested for cross-matching with donor platelets.
Yu HAN, Fan YANG, Lixin JIAO, Lingling LIU, Jianghong YU, Tingting NIE, Xin LIU, Rixin BAI, Xu YANG, Ying CHEN, Yanfei LI, Kaiye LI, Xiaotang YU   +12 more
doaj   +1 more source