Results 1 to 10 of about 181,399 (228)

Killer-Cell Immunoglobulin-like Receptor Diversity in an Admixed South American Population

Cells, 2022
Natural Killer (NK) cells are innate immune cells that mediate antiviral and antitumor responses. NK cell activation and induction of effector functions are tightly regulated by the integration of activating and inhibitory receptors such as killer ...
Marlon Castrillon, Nancy D. Marin, Amado J. Karduss-Urueta, Sonia Y. Velasquez, Cristiam M. Alvarez   +4 more
doaj   +1 more source

The KIR repertoire of a West African chimpanzee population is characterized by limited gene, allele, and haplotype variation

Frontiers in Immunology, 2023
IntroductionThe killer cell immunoglobulin-like receptors (KIR) play a pivotal role in modulating the NK cell responses, for instance, through interaction with major histocompatibility complex (MHC) class I molecules.
Natasja G. de Groot, Corrine M.C. Heijmans, Marit K.H. van der Wiel, Jesse Bruijnesteijn, Ronald E. Bontrop, Ronald E. Bontrop   +5 more
doaj   +1 more source

Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer

Cells, 2020
Natural killer cells (NK cells) play a major role in the immune response to cancer. An important element of NK target recognition is the binding of human leucocyte antigen (HLA) class I molecules by killer immunoglobulin-like receptors (KIRs). Colorectal
Roberto Diaz-Peña, Patricia Mondelo-Macía, Antonio José Molina de la Torre, Rebeca Sanz-Pamplona, Víctor Moreno, Vicente Martín   +5 more
doaj   +1 more source

The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus Control

Viruses, 2019
Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections.
Sarah K. A. Savoy, Jeanette E. Boudreau   +1 more
doaj   +1 more source

Steady state characteristics and stability limits of oil lubricated journal bearings using titanium dioxide nanoparticles as lubricant additives

Results in Engineering, 2023
The current work is presented to investigate the impact of titanium dioxide (TiO2) nanoparticle volume fraction and the nanoparticle aggregate sizes on the steady state characteristics and stability limits of journal bearings.
H. Awad, Khaled M. Abdou, E. Saber
doaj   +1 more source

Investigation of KIR/HLA relationship and other clinical variables after T-cell-replete haploidentical bone marrow transplantation in patients with acute myeloid leukemia (AML)

BMC Immunology, 2023
Background KIR/HLA mismatch in hematopoietic stem cell transplantation (HSCT), particularly in patients with acute myeloid leukemia (AML), was related to decreased recurrence rates, improved engraftment, and a reduction in graft-versus-host disease ...
Tahereh Bakhtiari, Mohammad Ahmadvand, Marjan Yaghmaie, Alireza Sadeghi, Seied Asadollah Mousavi, Tahereh Rostami, Mazdak Ganjalikhani-Hakemi   +6 more
doaj   +1 more source

High-resolution human KIR genotyping [PDF]

Immunogenetics, 2022
AbstractKiller immunoglobulin-like receptors (KIR) regulate the function of natural killer cells through interactions with various ligands on the surface of cells, thereby determining whether natural killer (NK) cells are to be activated or inhibited from killing the cell being interrogated. The genes encoding these proteins display extensive variation
Downing, Jonathan, D’Orsogna, Lloyd
openaire   +2 more sources

KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors

Frontiers in Immunology, 2020
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands.
Claudia Alicata, Elham Ashouri, Elham Ashouri, Elham Ashouri, Elham Ashouri, Neda Nemat-Gorgani, Neda Nemat-Gorgani, Neda Nemat-Gorgani, Lisbeth A. Guethlein, Lisbeth A. Guethlein, Wesley M. Marin, Sudan Tao, Sudan Tao, Lorenzo Moretta, Jill A. Hollenbach, John Trowsdale, James A. Traherne, Abbas Ghaderi, Peter Parham, Peter Parham, Paul J. Norman, Paul J. Norman, Paul J. Norman   +22 more
doaj   +1 more source

Family-based Association Study of Killer Cell Immunoglobulin-Like Receptor Genes with Leukemia

Acta Medica Bulgarica, 2019
NK cell function is controlled by the cell expression of killer immunoglobulin-like receptors (KIRs) and their ligation with the corresponding HLA ligands.
Varbanova V., Mihaylova S., Naumova E., Cotoc C., Mihaylova A.   +4 more
doaj   +1 more source

Distribution of killer cell immunoglobulin-like receptor (KIR) genes in a large, multi-centre cohort of Chinese donors

Annals of Human Biology, 2021
Background The killer cell immunoglobulin-like receptor (KIR), which mediates the killing function of NK cells, is an attractive candidate for adoptive cellular therapy.
Min He, Zhong-zheng Zheng, Qing-qing He, Dai-yang Li, Kuan-zhen Liao, Lin An, Qi Weng, Ning-juan Wang, Li-ping Wang, Qin Sun, Jian Wang, Pei-li Xiao, Ke-ming Du, Ming Jiang   +13 more
doaj   +1 more source