Results 11 to 20 of about 23,418 (184)
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Hypoglossal nerve stimulation is an effective treatment option for obstructive sleep apnea (OSA) in positive airway pressure therapy failure. Nonetheless, data regarding the functional effect of modifying stimulation parameters within each electrode configuration are limited.
Armin Steffen +4 more
wiley +1 more source
Killer-Cell Immunoglobulin-like Receptor Diversity in an Admixed South American Population
Cells, 2022 Natural Killer (NK) cells are innate immune cells that mediate antiviral and antitumor responses. NK cell activation and induction of effector functions are tightly regulated by the integration of activating and inhibitory receptors such as killer ...
Marlon Castrillon +4 more
doaj +1 more source
Autologous and allogeneic HLA KIR ligand environments and activating KIR control KIR NK‐cell functions [PDF]
European Journal of Immunology, 2008 AbstractNK‐cell function is regulated by a balance between inhibitory and activating killer cell immunoglobulin‐like receptors (KIR) that specifically recognize HLA class I molecules. Using KIR‐specific mAb to discriminate between KIR2DS1 and KIR2DL1 receptors, we show that KIR2DS1+ NK cells are C2‐alloreactive only from C2− individuals.
Morvan, Maelig +11 more
openaire +3 more sources
Molecular determinant-based typing of KIR alleles and KIR ligands [PDF]
Clinical Immunology, 2011 Killer cell immunoglobulin-like receptors (KIRs) regulate NK cell function. KIRs and their HLA ligands are highly polymorphic in nature with substantial allelic polymorphism. At present, there is a lack of an expedient method for KIR and HLA allele typing with relevant functional information.
Rafijul, Bari +6 more
openaire +2 more sources
Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer
Cells, 2020 Natural killer cells (NK cells) play a major role in the immune response to cancer. An important element of NK target recognition is the binding of human leucocyte antigen (HLA) class I molecules by killer immunoglobulin-like receptors (KIRs). Colorectal
Roberto Diaz-Peña +5 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionThe killer cell immunoglobulin-like receptors (KIR) play a pivotal role in modulating the NK cell responses, for instance, through interaction with major histocompatibility complex (MHC) class I molecules.
Natasja G. de Groot +5 more
doaj +1 more source
Activating KIR: iN Kase of KIR-ligand mismatch [PDF]
Blood, 2015 In this issue of Blood, Mancusi et al demonstrate that haploidentical hematopoietic stem cell transplantation (HSCT) from killer immunoglobulin-like receptor (KIR) ligand–mismatched donors with concomitant activating KIRs reduces nonrelapse mortality (NRM ...
openaire +2 more sources
Viruses, 2019 Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections.
Sarah K. A. Savoy +1 more
doaj +1 more source
BMC Immunology, 2023 Background KIR/HLA mismatch in hematopoietic stem cell transplantation (HSCT), particularly in patients with acute myeloid leukemia (AML), was related to decreased recurrence rates, improved engraftment, and a reduction in graft-versus-host disease ...
Tahereh Bakhtiari +6 more
doaj +1 more source
Family-based Association Study of Killer Cell Immunoglobulin-Like Receptor Genes with Leukemia
Acta Medica Bulgarica, 2019 NK cell function is controlled by the cell expression of killer immunoglobulin-like receptors (KIRs) and their ligation with the corresponding HLA ligands.
Varbanova V. +4 more
doaj +1 more source