Results 11 to 20 of about 181,399 (228)

KIR AA individuals possess strong inhibitory KIR alleles alongside HLA ligands that are protective against leukemia in the Chinese population [PDF]

Frontiers in Genetics
IntroductionThe killer-cell immunoglobulin-like receptor (KIR) gene cluster exhibits complicated diversity in haplotype content, copy-number variation (CNV), and allelic polymorphism.
Zhihui Deng, Jianxin Zhen, Yunan Li, Shuang Liang, Manru Zhang, Siqi Cai, Renhui Jiang, Zhichao Yang, Qiong Yu, Jinyong Wang, Jinyong Wang, Jinyong Wang, Jie Liu   +12 more
doaj   +2 more sources

The favorable role of homozygosity for killer immunoglobulin-like receptor (KIR) A haplotype in patients with advanced-stage classic Hodgkin lymphoma

Journal of Hematology and Oncology, 2016
Background Interim positron emission tomography after 2 cycles of ABVD (iPET-2) is a good predictor of outcome in advanced-stage classic Hodgkin lymphoma.
Giorgio La Nasa, Roberto Littera, Sara M Lai   +2 more
exaly   +3 more sources

Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations

Frontiers in Immunology, 2018
The killer-cell immunoglobulin-like receptor (KIR) genes regulate natural killer cell activity, influencing predisposition to immune mediated disease, and affecting hematopoietic stem cell transplantation (HSCT) outcome.
Jens Pruschke, Gerhard Schöfl, Bianca Schöne   +2 more
exaly   +3 more sources

Activating KIR: iN Kase of KIR-ligand mismatch [PDF]

Blood, 2015
In this issue of Blood, Mancusi et al demonstrate that haploidentical hematopoietic stem cell transplantation (HSCT) from killer immunoglobulin-like receptor (KIR) ligand–mismatched donors with concomitant activating KIRs reduces nonrelapse mortality (NRM ...
MANCUSI, ANTONELLA, RUGGERI, Loredana, URBANI, Elena, PIERINI, ANTONIO, Massei, Maria Speranza, CAROTTI, ALESSANDRA, Terenzi, Adelmo, FALZETTI, Franca, TOSTI, Antonella, TOPINI, FABIANA, BOZZA, Silvia, ROMANI, Luigina, Tognellini, Rita, Stern, Martin, Aversa, Franco, MARTELLI, Massimo Fabrizio, VELARDI, Andrea   +16 more
openaire   +6 more sources

De Novo Assembly of Plasmodium knowlesi Genomes From Clinical Samples Explains the Counterintuitive Intrachromosomal Organization of Variant SICAvar and kir Multiple Gene Family Members

Frontiers in Genetics, 2022
Plasmodium knowlesi, a malaria parasite of Old World macaque monkeys, is used extensively to model Plasmodium biology. Recently, P. knowlesi was found in the human population of Southeast Asia, particularly Malaysia. P.
Damilola R. Oresegun, Peter Thorpe, Ernest Diez Benavente, Susana Campino, Fauzi Muh, Robert William Moon, Taane Gregory Clark, Taane Gregory Clark, Janet Cox-Singh   +8 more
doaj   +1 more source

Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response

OncoImmunology, 2021
The antibody-dependent cellular cytotoxicity (ADCC) effector function of natural killer (NK) cells is one of the known mechanisms of action for rituximab-based anti-cancer immunotherapy.
Dhon Roméo Makanga, Maxime Jullien, Gaëlle David, Nolwenn Legrand, Catherine Willem, Léa Dubreuil, Alexandre Walencik, Cyrille Touzeau, Thomas Gastinne, Benoit Tessoulin, Steven Le Gouill, Béatrice Mahé, Katia Gagne, Patrice Chevallier, Béatrice Clemenceau, Christelle Retière   +15 more
doaj   +1 more source

Killer cell immunoglobulin-like receptor alleles influence susceptibility to occult hepatitis B infection in West African population

Journal of Public Health in Africa, 2023
Occult hepatitis B infection (OBI) is a public health problem in Burkina Faso. OBI represents a risk factor for the development of cirrhosis and hepatocellular carcinoma (HCC).
Momeiyi M. Bazie, Florencia W. Djigma, Mahamoudou Sanou, Pegdwendé A. Sorgho, Abdoul K. Ouattara, Dorcas Obiri-Yeboah, Nadege Kapieko, Herman K. Sombie, Prosper Bado, Edwige T. Yelemkoure, Isabelle T. Kiendrebeogo, Marius B. Nagalo, Albert T. Yonli, Jacques Simpore   +13 more
doaj   +1 more source

Study on relationship between platelet transfusion efficacy and KIR-HLA receptor-ligand compatibility

Zhongguo shuxue zazhi, 2023
Objective To study the correlation between platelet transfusion efficacy and KIR receptor-HLA ligand. Methods Thirty-three leukemia patients with positive HLA antibody were tested for cross-matching with donor platelets.
Yu HAN, Fan YANG, Lixin JIAO, Lingling LIU, Jianghong YU, Tingting NIE, Xin LIU, Rixin BAI, Xu YANG, Ying CHEN, Yanfei LI, Kaiye LI, Xiaotang YU   +12 more
doaj   +1 more source

Hydrodynamic Aspects of Staggered Spoilers fitted Subsea Pipelines [PDF]

Port Said Engineering Research Journal, 2017
Subsea pipelines are affected with many surrounding challenges. One of these challenges is the current-induced hydrodynamic stresses which affect the pipeline throughout its life span.
Ahmed El Shafei, Mohamed Kotb, Amr Hassan, Khalid Saqr   +3 more
doaj   +1 more source

Autologous and allogeneic HLA KIR ligand environments and activating KIR control KIR NK‐cell functions [PDF]

European Journal of Immunology, 2008
AbstractNK‐cell function is regulated by a balance between inhibitory and activating killer cell immunoglobulin‐like receptors (KIR) that specifically recognize HLA class I molecules. Using KIR‐specific mAb to discriminate between KIR2DS1 and KIR2DL1 receptors, we show that KIR2DS1+ NK cells are C2‐alloreactive only from C2− individuals.
Morvan, Maelig, David, Gaëlle, Sébille, Véronique, Perrin, Aurore, Gagne, Katia, Willem, Catherine, Kerdudou, Nolwenn, Denis, Laure, Clémenceau, Béatrice, Folléa, Gilles, Bignon, Jean-Denis, Retiere, Christelle   +11 more
openaire   +3 more sources