Results 21 to 30 of about 38,491 (220)

The KIR repertoire of a West African chimpanzee population is characterized by limited gene, allele, and haplotype variation

Frontiers in Immunology, 2023
IntroductionThe killer cell immunoglobulin-like receptors (KIR) play a pivotal role in modulating the NK cell responses, for instance, through interaction with major histocompatibility complex (MHC) class I molecules.
Natasja G. de Groot, Corrine M.C. Heijmans, Marit K.H. van der Wiel, Jesse Bruijnesteijn, Ronald E. Bontrop, Ronald E. Bontrop   +5 more
doaj   +1 more source

Identification of the ancestral killer immunoglobulin-like receptor gene in primates [PDF]

, 2006
Background: Killer Immunoglobulin-like Receptors (KIR) are essential immuno- surveillance molecules. They are expressed on natural killer and T cells, and interact with human leukocyte antigens.
Penny Coggill, Hanne Andersen, Sambrook Jennifer G, Piatak Mike, Carrington Mary, Jennifer G Sambrook, Coggill, P, Stephan Beck, Carrington, M, Piatak, M, Vernikos George S, Mike Piatak, Vernikos, GS, Bashirova Arman, Beck Stephan, Coggill Penny, Bashirova, A, Lifson, JD, Andersen, H, George S Vernikos, Lifson Jeff D, Beck, S, Jeff D Lifson, Andersen Hanne, Arman Bashirova, Mary Carrington, Sambrook, JG   +26 more
core   +1 more source

KIR-Fc construct binding to CD155-coated beads.

, 2022
KIR-Fc construct binding to biotin, CD112 and CD155 measured by flow cytometry. Binding of KIR2DL1, KIR2DL4 or KIR3DL1 to biotin (neg. control), CD112 or CD155 was assessed as median fluorescence intensity (MFI) in three independent experiments (n = 3 ...
Wilfredo F. Garcia-Beltran (10878573), Sarah Vollmers (9709508), Pia Fittje (12936621), Glòria Martrus (4344766), Frank Kirchhoff (94157), Kerri Hagemann (12936627), Daniel Sauter (109619), Angelique Hœlzemer (12936624), Marcus Altfeld (10455), Annika Niehrs (6811709), Christian Körner (151524)   +10 more
core   +1 more source

BRET-Based Approaches for Ion Channels: Emerging Applications and Future Directions. [PDF]

Arch Pharm (Weinheim)
Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Kock N, Heitzer L, Massa J, Taterra M, Bermúdez M, Koch O, Schiedel M.   +6 more
europepmc   +2 more sources

Activating KIR: iN Kase of KIR-ligand mismatch [PDF]

Blood, 2015
In this issue of Blood, Mancusi et al demonstrate that haploidentical hematopoietic stem cell transplantation (HSCT) from killer immunoglobulin-like receptor (KIR) ligand–mismatched donors with concomitant activating KIRs reduces nonrelapse mortality (NRM ...
openaire   +2 more sources

Killer cell immunoglobulin-like receptors and their ligands : assessment of potential diagnostic and immunotherapeutic value [PDF]

, 2014
Human natural killer (NK) cells constitute an important arm of the innate immune system, which participates in protection against viral infections and elimination of malignant diseases.
Czaja, Karol Gustaw
core   +1 more source

The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus Control

Viruses, 2019
Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections.
Sarah K. A. Savoy, Jeanette E. Boudreau   +1 more
doaj   +1 more source

Investigation of KIR/HLA relationship and other clinical variables after T-cell-replete haploidentical bone marrow transplantation in patients with acute myeloid leukemia (AML)

BMC Immunology, 2023
Background KIR/HLA mismatch in hematopoietic stem cell transplantation (HSCT), particularly in patients with acute myeloid leukemia (AML), was related to decreased recurrence rates, improved engraftment, and a reduction in graft-versus-host disease ...
Tahereh Bakhtiari, Mohammad Ahmadvand, Marjan Yaghmaie, Alireza Sadeghi, Seied Asadollah Mousavi, Tahereh Rostami, Mazdak Ganjalikhani-Hakemi   +6 more
doaj   +1 more source

Family-based Association Study of Killer Cell Immunoglobulin-Like Receptor Genes with Leukemia

Acta Medica Bulgarica, 2019
NK cell function is controlled by the cell expression of killer immunoglobulin-like receptors (KIRs) and their ligation with the corresponding HLA ligands.
Varbanova V., Mihaylova S., Naumova E., Cotoc C., Mihaylova A.   +4 more
doaj   +1 more source

IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic Hepatitis C virus infection in a European cohort: A cross-sectional study [PDF]

, 2011
Background To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-
Hellard, M, Powell, Elizabeth, Ahlenstiel, G., Smedile, Antonina, Bassendine, Margaret, Hammond, E., O'Connor, Kate S, Armstrong, Nicola J, Stewart, Graeme J, Müller Tobias, Silvana Gaudieri, Mallal Simon, Armstrong Nicola J., Powell Elizabeth, Graeme J Stewart, Bassendine, M, Abate, ML, Jacob Nattermann, Irving, WL, Ahlenstiel, G, Simon Mallal, Negro, F, Stewart, Graeme J., Suppiah, Vijayaprakash, Matthews, G, Suppiah Vijayaprakash, Gaudieri Silvana, Bochud Pierre-Yves, null null, Nattermann, J, Vijayaprakash Suppiah, Hammond, Emma, Graeme J. Stewart, Hellard Margaret, Bochud, P-Y, Mallal, S., Negro, F., Ahlenstiel, Golo (R18999), O'Connor, KS, Smedile, A, Booth, DR, Powell, E, George Jacob, Gaudieri, S., Negro Francesco, Pierre-Yves Bochud, Irving, W.L., David Dunn, Abate, Maria L., Dore Gregory J., Hellard, M., International Hepatitis C Genetics Consortium (IHCGC), Spengler, U., William L Irving, Dunn David, David Sheridan, Riordan Stephen, Berg Thomas, Dunn, D.S., Stewart Graeme J., Mathews, Gail, Weltman, Martin, Ulrich Spengler, Nattermann Jacob, Mallai, Simon, Dunn, D, Francesco Negro, Berg, Thomas, for the International Hepatitis C Genetics Consortium (IHCGC), Gregory J. Dore, Sheridan, D, Abate Maria Lorena, Jacob George, Nicola J Armstrong, Matthews Gail, Mallal, S, Matthews, Gail, Booth, David R, Dore, G.J., Müller, T., Kate S O'Connor, Armstrong, Nicola J., Dore, Gregory J, Gail Matthews, Spengler Ulrich, Müller, T, Booth, David R., Berg, T., Irving, William L., Spengler, U, Booth, D.R., Spengler, Ulrich, Suppiah, V, Powell, E., Martin Weltman, Emma Hammond, Dunn, David, Thomas Berg, Suppiah, Vijay, Matthews, G., Abate, Maria Lorena, Bassendine, M., Berg, T, Riordan, Stephen, Hammond, E, Muller, Tobias, Ahlenstiel, Golo, Nattermann, J., Sheridan David, Smedile Antonina, Kate S. O'Connor, Mallal, Simon, Sheridan, D., Hammond Emma, David R. Booth, Irving William L., Stewart, GJ, Maria Lorena Abate, O'Connor, Kate S., Antonina Smedile, Golo Ahlenstiel, Armstrong, N.J., Margaret Hellard, Dore, GJ, O'Connor Kate S., Gaudieri, S, Hellard, Margaret, David R Booth, Weltman Martin, Riordan, S, Irving, William L, Margaret Bassendine, Tobias Müller, Armstrong, NJ, Weltman, M., Bassendine Margaret, Booth David R., Elizabeth Powell, Smedile, A., William L. Irving, Dore, Gregory J., Stephen Riordan, Weltman, M, Sheridan, David, Negro, Francesco, Bochud, PY, Riordan, S., Bochud, Pierre-Yves, Gregory J Dore, O'Connor, K.S., George, J, Nicola J. Armstrong, Suppiah, V., Stewart, G.J., Ahlenstiel Golo, George, J., George, Jacob, Nattermann, Jacob, Abate, M.L., Gaudieri, Silvana   +159 more
core   +1 more source