Results 31 to 40 of about 23,418 (184)

Distribution of Killer-Cell Immunoglobulin-Like Receptor Genes and Combinations of Their Human Leucocyte Antigen Ligands in 11 Ethnic Populations in China

Cells, 2019
The aim of this study was to analyze the distribution of killer-cell immunoglobulin-like receptor (KIR) genes and their human leucocyte antigen (HLA) ligand combinations in different original ethnic populations in China, and thus, to provide relevant ...
Yufeng Yao, Lei Shi, Jiankun Yu, Shuyuan Liu, Yufen Tao, Li Shi   +5 more
doaj   +1 more source

Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and Disease

Frontiers in Cell and Developmental Biology, 2022
Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health. Failure to control potassium balance results in disease, including cardiac arrythmias and developmental disorders.
Natalie A. Hager, Ceara K. McAtee, Mitchell A. Lesko, Allyson F. O’Donnell   +3 more
doaj   +1 more source

Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method

Cell Genomics, 2022
Summary: The killer cell immunoglobulin-like receptor (KIR) recognizes human leukocyte antigen (HLA) class I molecules and modulates the function of natural killer cells.
Saori Sakaue, Kazuyoshi Hosomichi, Jun Hirata, Hirofumi Nakaoka, Keiko Yamazaki, Makoto Yawata, Nobuyo Yawata, Tatsuhiko Naito, Junji Umeno, Takaaki Kawaguchi, Toshiyuki Matsui, Satoshi Motoya, Yasuo Suzuki, Hidetoshi Inoko, Atsushi Tajima, Takayuki Morisaki, Koichi Matsuda, Yoichiro Kamatani, Kazuhiko Yamamoto, Ituro Inoue, Yukinori Okada   +20 more
doaj   +1 more source

A federated framework for speech-based early detection of Alzheimer’s disease

Advances in Computing and Engineering
The development of artificial intelligence for Alzheimer’s disease (AD) diagnostics is often hindered by data privacy regulations that prevent the aggregation of sensitive patient information.
Mohamed Mourad Abdellattif, Abdelrahman Mohamed Farouk, Nada Hamada Ahmed, Nadine Ahmed Elquersh, Ahmed Hamdy Elshennawy, Noha S. Tawfik   +5 more
doaj   +1 more source

Estimation of German KIR Allele Group Haplotype Frequencies

Frontiers in Immunology, 2020
The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor (KIR) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research.
Ute V. Solloch, Daniel Schefzyk, Gesine Schäfer, Carolin Massalski, Maja Kohler, Jens Pruschke, Annett Heidl, Johannes Schetelig, Johannes Schetelig, Alexander H. Schmidt, Alexander H. Schmidt, Vinzenz Lange, Jürgen Sauter   +12 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

KIR B or not to be?...that is the question for ALL [PDF]

Blood, 2014
Although antihost alloreactivity varies among HCT donors, differences are most pronounced in the human leukocyte antigen (HLA) mismatched setting, where mismatch between donor KIR and recipient KIR ligands (ie, HLA) are more frequent. It was initially assumed that natural killer (NK) cells kill targets without restriction by the HLA complex.
Michael R, Verneris, Jeffrey S, Miller
openaire   +2 more sources

Functional Repurposing of Magnetic Nanoparticle‐Assisted Hyperthermia for Immune Cell Labelling and Tracking

Small Methods, EarlyView.
We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino   +8 more
wiley   +1 more source

Doenças reumatológicas autoimunes e sua associação com os genes killer immunoglobulin-like receptors Autoimmune rheumatic diseases and their association with killer immunoglobulin-like receptor genes

Revista Brasileira de Reumatologia, 2011
Os genes Killer Immunoglobulin-like Receptors (KIR) expressam-se como receptores que estimulam ou inibem as células Natural Killer (NK). As células NK fazem parte da imunidade inata e através de seus receptores KIR identificam células-alvo que apresentam
Patricia Hartstein Salim, Mariana Jobim, Luiz Fernando Jobim, Ricardo Machado Xavier   +3 more
doaj   +1 more source