Results 31 to 40 of about 21,873 (185)

Особливості розподілу та частота KIR-генів у жінок із регулярними ранніми репродуктивними втратами

Фактори експериментальної еволюції організмів, 2017
Aim. KIR (killer cell immunoglobulin-like receptors) are the transmembranous glycoprotein receptors, role of which is to activate or inhibit the functional activity of cells, the surfaces of which they are located on.
O. I. Terpyliak, D. V. Zastavna, N. V. Helner, S. V. Osidach   +3 more
doaj   +1 more source

Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and Disease

Frontiers in Cell and Developmental Biology, 2022
Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health. Failure to control potassium balance results in disease, including cardiac arrythmias and developmental disorders.
Natalie A. Hager, Ceara K. McAtee, Mitchell A. Lesko, Allyson F. O’Donnell   +3 more
doaj   +1 more source

Distribution of Killer-Cell Immunoglobulin-Like Receptor Genes and Combinations of Their Human Leucocyte Antigen Ligands in 11 Ethnic Populations in China

Cells, 2019
The aim of this study was to analyze the distribution of killer-cell immunoglobulin-like receptor (KIR) genes and their human leucocyte antigen (HLA) ligand combinations in different original ethnic populations in China, and thus, to provide relevant ...
Yufeng Yao, Lei Shi, Jiankun Yu, Shuyuan Liu, Yufen Tao, Li Shi   +5 more
doaj   +1 more source

Effect of shaft eccentricity on dynamic characteristics for different geometries of stationary labyrinth seals

Alexandria Engineering Journal, 2020
The present paper introduces a theoretical study carried out to investigate the effect of shaft lateral misalignment on the dynamic characteristics of labyrinth seals under stationary conditions.
E. Saber, Khaled M. Abdou, R. Afify
doaj   +1 more source

A federated framework for speech-based early detection of Alzheimer’s disease

Advances in Computing and Engineering
The development of artificial intelligence for Alzheimer’s disease (AD) diagnostics is often hindered by data privacy regulations that prevent the aggregation of sensitive patient information.
Mohamed Mourad Abdellattif, Abdelrahman Mohamed Farouk, Nada Hamada Ahmed, Nadine Ahmed Elquersh, Ahmed Hamdy Elshennawy, Noha S. Tawfik   +5 more
doaj   +1 more source

Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method

Cell Genomics, 2022
Summary: The killer cell immunoglobulin-like receptor (KIR) recognizes human leukocyte antigen (HLA) class I molecules and modulates the function of natural killer cells.
Saori Sakaue, Kazuyoshi Hosomichi, Jun Hirata, Hirofumi Nakaoka, Keiko Yamazaki, Makoto Yawata, Nobuyo Yawata, Tatsuhiko Naito, Junji Umeno, Takaaki Kawaguchi, Toshiyuki Matsui, Satoshi Motoya, Yasuo Suzuki, Hidetoshi Inoko, Atsushi Tajima, Takayuki Morisaki, Koichi Matsuda, Yoichiro Kamatani, Kazuhiko Yamamoto, Ituro Inoue, Yukinori Okada   +20 more
doaj   +1 more source

Molecular Study of Iraqi Patients with Brain Tumors Infection with HTLV-1

Medical Journal of Babylon
Background: HTLV-1 is associated with the chronic, persistent infection of T cells, which can result in neoplastic or inflammatory diseases; HTLV-1 indirectly damages the central nervous system to cause associated neuropathies starting with the virus ...
Ataa Khalil Al-Shamari, Shakir H. Mohammed Al-Alwany   +1 more
doaj   +1 more source

Doenças reumatológicas autoimunes e sua associação com os genes killer immunoglobulin-like receptors Autoimmune rheumatic diseases and their association with killer immunoglobulin-like receptor genes

Revista Brasileira de Reumatologia, 2011
Os genes Killer Immunoglobulin-like Receptors (KIR) expressam-se como receptores que estimulam ou inibem as células Natural Killer (NK). As células NK fazem parte da imunidade inata e através de seus receptores KIR identificam células-alvo que apresentam
Patricia Hartstein Salim, Mariana Jobim, Luiz Fernando Jobim, Ricardo Machado Xavier   +3 more
doaj   +1 more source

A KIR-TLR connection

Blood, 2010
Killer immunoglobulin-like receptors (KIRs) are well-known for binding human leukocyte antigen (HLA) and allowing natural killer (NK) cells to monitor HLA levels on host cells. Unexpectedly, Sivori and colleagues have found that certain KIRs can also bind microbial nucleic acid and deliver it ...
openaire   +3 more sources

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source