Results 51 to 60 of about 38,491 (220)

KIR B or not to be?...that is the question for ALL [PDF]

Blood, 2014
Although antihost alloreactivity varies among HCT donors, differences are most pronounced in the human leukocyte antigen (HLA) mismatched setting, where mismatch between donor KIR and recipient KIR ligands (ie, HLA) are more frequent. It was initially assumed that natural killer (NK) cells kill targets without restriction by the HLA complex.
Michael R, Verneris, Jeffrey S, Miller
openaire   +2 more sources

Functional Repurposing of Magnetic Nanoparticle‐Assisted Hyperthermia for Immune Cell Labelling and Tracking

Small Methods, EarlyView.
We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino   +8 more
wiley   +1 more source

Nasal Epithelial Immune Signatures Are Associated With Age‐Dependent Asthma Trajectories in Early Life

Allergy, EarlyView.
Nasal epithelial transcriptomics identified three cytokine‐associated epithelial immune programs linked to childhood asthma phenotypes. Age‐associated epithelial polarization shifted from IFN/type‐17‐associated toward type‐2‐associated programs after 3 years of age.
Constanze A. Jakwerth, Sabina Illi, Helen Charles, Madlen Oelsner, Amr A. Gabr, Ulrich M. Zissler, Anna Erb, Martin Feuerherd, Felix Drost, Maren Büttner, Benjamin Schubert, Nicole Maison, Jimmy Omony, Markus Weckmann, Ruth Grychtol, Anna‐Maria Dittrich, Svenja Foth, Chrysanthi Skevaki, Tobias Trojan, Silke van Koningsbruggen‐Rietschel, Gesine Hansen, Thomas Bahmer, Klaus F. Rabe, Folke Brinkmann, Matthias Volkmar Kopp, Ulrike Protzer, Adam M. Chaker, Bianca Schaub, Erika von Mutius, Carsten B. Schmidt‐Weber, the ALLIANCE Study Group as part of the German Center for Lung Research (DZL), Mira Bürk, Sybille Contento, Markus Ege, Kristina Gottschau, Silvia Gschwendtner, Alexander Hose, Lena Lagally, Michael Schloter, Lena Ullemeyer, Esther Zeitlmann, Mustafa Abdo, Heike Biller, Karoline I. Gaede, Clara Haug, Nikolas Jacobs, Anne‐Marie Kirsten, Inke R. König, Lea Kronziel, Gyde Nissen, Frauke Pedersen, Loana Pennerd, Isabell Ricklefs, Vera Veith, Henrik Watz, Marie Bickes, Mifflin‐Rae Calvero, David S. DeLuca, Svenja Gaedcke, Anika Habener, Christine Happle, Adan Chari Jirmo, Bin Liu, Lennart Riemann, Nicolaus Schwerk, Inga Jerrentrup, Harald Renz, Stefanie Weber, Miguel A. Alejandre Alcazar, Samira Blau, Ernst Rietschel, Jan‐Christoph Thomassen   +71 more
wiley   +1 more source

Doenças reumatológicas autoimunes e sua associação com os genes killer immunoglobulin-like receptors Autoimmune rheumatic diseases and their association with killer immunoglobulin-like receptor genes

Revista Brasileira de Reumatologia, 2011
Os genes Killer Immunoglobulin-like Receptors (KIR) expressam-se como receptores que estimulam ou inibem as células Natural Killer (NK). As células NK fazem parte da imunidade inata e através de seus receptores KIR identificam células-alvo que apresentam
Patricia Hartstein Salim, Mariana Jobim, Luiz Fernando Jobim, Ricardo Machado Xavier   +3 more
doaj   +1 more source

Estimation of German KIR Allele Group Haplotype Frequencies

Frontiers in Immunology, 2020
The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor (KIR) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research.
Ute V. Solloch, Daniel Schefzyk, Gesine Schäfer, Carolin Massalski, Maja Kohler, Jens Pruschke, Annett Heidl, Johannes Schetelig, Johannes Schetelig, Alexander H. Schmidt, Alexander H. Schmidt, Vinzenz Lange, Jürgen Sauter   +12 more
doaj   +1 more source

A KIR-TLR connection

Blood, 2010
Killer immunoglobulin-like receptors (KIRs) are well-known for binding human leukocyte antigen (HLA) and allowing natural killer (NK) cells to monitor HLA levels on host cells. Unexpectedly, Sivori and colleagues have found that certain KIRs can also bind microbial nucleic acid and deliver it ...
openaire   +3 more sources

Optimizing cord blood unit selection to improve survival after single‐unit unrelated cord blood transplantation for adult myelodysplastic syndrome

British Journal of Haematology, EarlyView.
Summary Unrelated cord blood transplantation (CBT) is an important alternative donor option for adult patients with myelodysplastic syndrome (MDS); however, the prognostic significance of cord blood unit characteristics following CBT remains unclear and may vary according to disease risk.
Takaaki Konuma, Machiko Fujioka, Kyoko Fuse, Tatsuya Suwabe, Hiroki Hosoi, Naoyuki Uchida, Masatsugu Tanaka, Kazuto Ogura, Satoshi Takahashi, Makoto Onizuka, Takeshi Maeda, Noriko Doki, Yasufumi Uehara, Atsushi Wake, Masatoshi Sakurai, Naoyuki Anzai, Toshimitsu Ueki, Yoshiko Matsuhashi, Koji Kawamura, Fumihiko Ishimaru, Junya Kanda, Marie Ohbiki, Yoshiko Atsuta, Hidehiro Itonaga   +23 more
wiley   +1 more source

KIR-expressing CD8⁺ T cells bind HLA-C-multimers epitope-independently.

, 2018
(A) Exemplary depiction of KIR-expression on CD8+ T cells by KIR2DL2/3 staining. (B) Multimer staining of CD8+ T cells for the indicated epitopes and overlay of multimer+ CD8+ T cells (blue) and KIR2DL2/3 staining (grey).
Michael Neuenhahn (168944), Dirk H. Busch (125319), Volker Hösel (3701041), Stefan Dreher (168926), Uwe Heemann (285995), Fabian Schlott (414947), Dominik Steubl (3159330), Stefanie Ameres (414946), Andreas Moosmann (38220)   +8 more
core   +1 more source

Molecular Study of Iraqi Patients with Brain Tumors Infection with HTLV-1

Medical Journal of Babylon
Background: HTLV-1 is associated with the chronic, persistent infection of T cells, which can result in neoplastic or inflammatory diseases; HTLV-1 indirectly damages the central nervous system to cause associated neuropathies starting with the virus ...
Ataa Khalil Al-Shamari, Shakir H. Mohammed Al-Alwany   +1 more
doaj   +1 more source

The extensive polymorphism of KIR genes [PDF]

Immunology, 2009
SummaryThe functions of human natural killer (NK) cells are controlled by diverse families of antigen receptors. Prominent among these are the killer cell immunoglobulin‐like receptors (KIR), a family of genes clustered in one of the most variable regions of the human genome.
Derek, Middleton, Faviel, Gonzelez
openaire   +2 more sources