Results 51 to 60 of about 181,399 (228)

Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. [PDF]

, 1996
The killer cell inhibitory receptors (KIRs) are surface glycoproteins expressed by natural killer (NK) and T cells that specifically recognize defined groups of polymorphic human histocompatibility leukocyte antigen (HLA) class I molecules.
Chang, C, D'Andrea, A, Lanier, LL, Phillips, JH   +3 more
core  

Estimation of German KIR Allele Group Haplotype Frequencies

Frontiers in Immunology, 2020
The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor (KIR) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research.
Ute V. Solloch, Daniel Schefzyk, Gesine Schäfer, Carolin Massalski, Maja Kohler, Jens Pruschke, Annett Heidl, Johannes Schetelig, Johannes Schetelig, Alexander H. Schmidt, Alexander H. Schmidt, Vinzenz Lange, Jürgen Sauter   +12 more
doaj   +1 more source

Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method

Cell Genomics, 2022
Summary: The killer cell immunoglobulin-like receptor (KIR) recognizes human leukocyte antigen (HLA) class I molecules and modulates the function of natural killer cells.
Saori Sakaue, Kazuyoshi Hosomichi, Jun Hirata, Hirofumi Nakaoka, Keiko Yamazaki, Makoto Yawata, Nobuyo Yawata, Tatsuhiko Naito, Junji Umeno, Takaaki Kawaguchi, Toshiyuki Matsui, Satoshi Motoya, Yasuo Suzuki, Hidetoshi Inoko, Atsushi Tajima, Takayuki Morisaki, Koichi Matsuda, Yoichiro Kamatani, Kazuhiko Yamamoto, Ituro Inoue, Yukinori Okada   +20 more
doaj   +1 more source

The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin

Annals of Neurology, EarlyView.
Objectives The objective of this study was to elucidate differences in the cumulative incidence of Leucine‐rich repeat kinase 2 (LRRK2) p.Gly2019Ser‐related Parkinson's disease (PD; LRRK2‐PD) between ancestries and countries. Methods We included 922 unrelated p.Gly2019Ser variant carriers (affected = 762 and unaffected = 160) from the Global Parkinson ...
Theresa Lüth, Björn‐Hergen Laabs, Sebastian Sendel, Inke R. König, Amke Caliebe, Alastair J. Noyce, Laurel A. Screven, Soraya Bardien, Matthew Farrer, Faycel Hentati, Rim Amouri, Christine Klein, Samia Ben Sassi, Joanne Trinh, Global Parkinson's Genetics Program (GP2)   +14 more
wiley   +1 more source

Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by Gβγ subunits and function as heteromultimers [PDF]

, 1995
Guanine nucleotide-binding proteins (G proteins) activate K+ conductances in cardiac atrial cells to slow heart rate and in neurons to decrease excitability. cDNAs encoding three isoforms of a G-protein-coupled, inwardly rectifying K+ channel (GIRK) have
Davidson, Norman, Kofuji, Paulo, Lester, Henry A.   +2 more
core  

KIR genotype distribution among patients with multiple myeloma: Higher prevalence of KIR 2DS4 and KIR 2DS5 genes

Meta Gene, 2014
Natural killer (NK) cells possess an antitumor activity against multiple myeloma cells proven by the susceptibility of plasmocytes to NK lysis. In the early stage of MM, the killing of MM cells is mediated by natural cytotoxicity receptors (NRC) and NKG2D-dependent pathway, while in the late stage, NK cells lose their killing potential against MM cells
Hoteit, R., Bazarbachi, A., Antar, A., Salem, Z., Shammaa, D., Mahfouz, R.   +5 more
openaire   +2 more sources

Mature T‐cell leukemia/lymphoma with an NK‐like immunophenotype: A report of 7 cases

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Distinguishing T‐cell from NK‐cell neoplasms can occasionally be challenging, as neoplastic T cells can lose T‐cell markers such as surface CD3 (sCD3) and CD5 while acquiring NK‐cell markers such as CD16, CD56, and CD94. In this study, we present a series of 7 mature T‐cell lymphoma/leukemia cases with NK‐like immunophenotypes to clarify ...
Wei J. Wang, Sa A. Wang, Hong Fang, Jeffrey L. Jorgensen, Shimin Hu, Lianqun Qiu, Jie Xu, L. Jeffrey Medeiros, Wei Wang   +8 more
wiley   +1 more source

A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia. [PDF]

, 2015
In sub-Saharan Africans, maternal mortality is unacceptably high, with >400 deaths per 100,000 births compared with
Byamugisha, Josaphat, Chazara, Olympe, Colucci, Francesco, Elliott, Alison M, Farrell, Lydia, Hiby, Susan E, Jayaraman, Jyothi, Kaleebu, Pontiano, Lougee, Emma, Mirembe, Florence, Moffett, Ashley, Nakimuli, Annettee, Nemat-Gorgani, Neda, Norman, Paul J, Parham, Peter, Traherne, James A, Trowsdale, John, Tukwasibwe, Stephen, Vaughan, Robert W   +18 more
core   +2 more sources

Evaluation of the association between KIR polymorphisms and systemic sclerosis: a meta-analysis

Advances in Rheumatology, 2020
Background The results of investigations on the association between killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and the risk of systemic sclerosis (SSc) are inconsistent.
Elham Karimizadeh, Shayan Mostafaei, Saeed Aslani, Farhad Gharibdoost, Ricardo Machado Xavier, Patricia Hartstein Salim, Hoda Kavosi, Elham Farhadi, Mahdi Mahmoudi   +8 more
doaj   +1 more source

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source