Results 61 to 70 of about 21,873 (185)

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera

Channels
Kir (inwardly rectifying potassium) channels that play key roles in maintaining potassium homeostasis, neuronal excitability, and osmoregulation have been cloned and characterized in a variety of insects.
Fabien Sourisseau, Craig A. Doupnik, Pierre Charnet, Mohamed Chahine   +3 more
doaj   +1 more source

Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations

Frontiers in Immunology, 2018
The killer-cell immunoglobulin-like receptor (KIR) genes regulate natural killer cell activity, influencing predisposition to immune mediated disease, and affecting hematopoietic stem cell transplantation (HSCT) outcome.
Ines Wagner, Daniel Schefzyk, Jens Pruschke, Gerhard Schöfl, Bianca Schöne, Nicole Gruber, Kathrin Lang, Jan Hofmann, Christine Gnahm, Bianca Heyn, Wesley M. Marin, Ravi Dandekar, Jill A. Hollenbach, Johannes Schetelig, Johannes Schetelig, Julia Pingel, Paul J. Norman, Jürgen Sauter, Alexander H. Schmidt, Alexander H. Schmidt, Vinzenz Lange   +20 more
doaj   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Особливості KIR-генотипів у жінок з доімплантаційними втратами при застосуванні допоміжних репродуктивних технологій

Фактори експериментальної еволюції організмів
Мета. Аналіз частоти та розподілу KIR-генотипів у жінок з повторними доімплантаційними втратами при застосуванні допоміжних репродуктивних технологій у порівнянні з жінками контрольної групи. Методи.
K. O. Sosnina, D. V. Zastavna, B. I. Tretiak, O. I. Terpylyak   +3 more
doaj   +1 more source

KIR genotype distribution among patients with multiple myeloma: Higher prevalence of KIR 2DS4 and KIR 2DS5 genes

Meta Gene, 2014
Natural killer (NK) cells possess an antitumor activity against multiple myeloma cells proven by the susceptibility of plasmocytes to NK lysis. In the early stage of MM, the killing of MM cells is mediated by natural cytotoxicity receptors (NRC) and NKG2D-dependent pathway, while in the late stage, NK cells lose their killing potential against MM cells
Hoteit, R., Bazarbachi, A., Antar, A., Salem, Z., Shammaa, D., Mahfouz, R.   +5 more
openaire   +2 more sources

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Natural Killer Cells Offer Differential Protection From Leukemia in Chinese Southern Han

Frontiers in Immunology, 2019
Interactions of human natural killer (NK) cell inhibitory receptors with polymorphic HLA-A, -B and -C molecules educate NK cells for immune surveillance against tumor cells. The KIR A haplotype encodes a distinctive set of HLA-specific NK cell inhibiting
Zhihui Deng, Jun Zhao, Siqi Cai, Ying Qi, Qiong Yu, Maureen P. Martin, Xiaojiang Gao, Rui Chen, Jiacai Zhuo, Jianxin Zhen, Jianxin Zhen, Mingjie Zhang, Guobin Zhang, Liumei He, Hongyan Zou, Liang Lu, Weigang Zhu, Wenxu Hong, Mary Carrington, Mary Carrington, Paul J. Norman   +20 more
doaj   +1 more source

Does Japanʼs Aid Promote the Economic Growth of Pacific Island Countries?

Asia &the Pacific Policy Studies, Volume 13, Issue 3, September 2026.
ABSTRACT Pacific Island countries (PICs) are among the worldʼs most aid‐dependent nations. This study examines relations between Japanʼs aid and the economic growth of 13 PICs during 2000–2023. After evaluating overall effects of Japanʼs aid, specific types are analysed: economic, social, production, and multi‐sector aid.
Wesley Steve Aru
wiley   +1 more source

Chronic Liver Disease: Assessing Inflammation and Fibrosis Using Three‐Dimensional MR Elastography With Same‐Day Biopsy in a Prospective Cohort

Journal of Magnetic Resonance Imaging, Volume 64, Issue 1, Page 306-319, July 2026.
ABSTRACT Background Three‐dimensional (3D) MR elastography (MRE) derives viscoelastic parameters that may reflect inflammation, but their frequency dependence and the influence of steatosis on inflammation grading and fibrosis staging remain unclear. Purpose To investigate 3D multifrequency MRE for assessing hepatic inflammation, fibrosis stage across ...
Shan Cai, Christian Simonsson, Markus Karlsson, Wile Balkhed, Jens Tellman, Simone Ignatova, Patrik Nasr, Mattias Ekstedt, Stergios Kechagias, Wolf C. Bartholomä, Nils Dahlström, Peter Lundberg   +11 more
wiley   +1 more source