Results 61 to 70 of about 23,418 (184)

Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera

Channels
Kir (inwardly rectifying potassium) channels that play key roles in maintaining potassium homeostasis, neuronal excitability, and osmoregulation have been cloned and characterized in a variety of insects.
Fabien Sourisseau, Craig A. Doupnik, Pierre Charnet, Mohamed Chahine   +3 more
doaj   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Design and Validation of a Multiplex KIR and HLA Class I Genotyping Method Using Next Generation Sequencing

Frontiers in Immunology, 2018
Killer cell immunoglobulin-like receptors (KIR), considered the most polymorphic natural killer (NK) cell regulators, bind HLA class-I molecules or still unknown ligands.
Laia Closa, Laia Closa, Francisco Vidal, Francisco Vidal, Francisco Vidal, Maria J. Herrero, Jose L. Caro, Jose L. Caro   +7 more
doaj   +1 more source

Does Japanʼs Aid Promote the Economic Growth of Pacific Island Countries?

Asia &the Pacific Policy Studies, Volume 13, Issue 3, September 2026.
ABSTRACT Pacific Island countries (PICs) are among the worldʼs most aid‐dependent nations. This study examines relations between Japanʼs aid and the economic growth of 13 PICs during 2000–2023. After evaluating overall effects of Japanʼs aid, specific types are analysed: economic, social, production, and multi‐sector aid.
Wesley Steve Aru
wiley   +1 more source

Особливості KIR-генотипів у жінок з доімплантаційними втратами при застосуванні допоміжних репродуктивних технологій

Фактори експериментальної еволюції організмів
Мета. Аналіз частоти та розподілу KIR-генотипів у жінок з повторними доімплантаційними втратами при застосуванні допоміжних репродуктивних технологій у порівнянні з жінками контрольної групи. Методи.
K. O. Sosnina, D. V. Zastavna, B. I. Tretiak, O. I. Terpylyak   +3 more
doaj   +1 more source

Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations

Frontiers in Immunology, 2018
The killer-cell immunoglobulin-like receptor (KIR) genes regulate natural killer cell activity, influencing predisposition to immune mediated disease, and affecting hematopoietic stem cell transplantation (HSCT) outcome.
Ines Wagner, Daniel Schefzyk, Jens Pruschke, Gerhard Schöfl, Bianca Schöne, Nicole Gruber, Kathrin Lang, Jan Hofmann, Christine Gnahm, Bianca Heyn, Wesley M. Marin, Ravi Dandekar, Jill A. Hollenbach, Johannes Schetelig, Johannes Schetelig, Julia Pingel, Paul J. Norman, Jürgen Sauter, Alexander H. Schmidt, Alexander H. Schmidt, Vinzenz Lange   +20 more
doaj   +1 more source

Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short‐Term Spatial Memory via Multiple Ionic and Signaling Mechanisms

Advanced Biology, Volume 10, Issue 8, August 2026.
Ghrelin excites the dentate gyrus (DG) granule cells via GHSR‐mediated modulation of diverse ionic channels and activation of D1R, cAMP, and EPAC2. Similarly, overnight calorie restriction alters neuronal excitability in a ghrelin‐dependent manner. Infusion of ghrelin directly into the DG improves short‐term spatial memory in the Y‐maze, providing ...
Chidiebele S. Oraegbuna, Phani K. Kola, Simon L. Griggs, Saobo Lei   +3 more
wiley   +1 more source

Overcoming Radiation Resistance: Ferroptosis Induction to Sensitize Solid Tumors to Radiation Therapy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal, Caden M. Fritson, Alexandra Seas, Heidi Vieira, Surinder K. Batra   +4 more
wiley   +1 more source

Investigation of the Prevalence of the HLA‐B*15:02 Allele in the Asian Populations: A Comprehensive Analysis Through Using AFND

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims The HLA‐B*15:02 allele is related to a high risk of severe cutaneous adverse drug reactions (SCARs) in patients taking certain antiepileptic drugs. However, its prevalence in the Asian population and the number of drugs linked to SCARs due to the carriage of this variant are relatively underexplored.
Mohitosh Biswas, Murshadul Alam Murad, Maliheh Ershadian, Chonlaphat Sukasem   +3 more
wiley   +1 more source

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, EarlyView.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source