Results 71 to 80 of about 21,873 (185)

Differential effects of lipid composition on the thermal and functional properties of membrane associated CYP2J2

Protein Science, Volume 35, Issue 7, July 2026.
Abstract CYP2J2 is a membrane‐bound cytochrome P450 that is expressed in cardiomyocytes, where it is known to metabolize arachidonic acid into cardioprotective epoxyeicosatrienoic acids (EETs). It consists of transmembrane domains embedded in the hydrophobic segments of the cell membrane and surrounded by various lipids.
Rajatabha Das, Henry M. Mastrion, Harrison B. Vassar, Aditi Das   +3 more
wiley   +1 more source

Establishment of Q-PCR method for qualitative testing of the presence or absence of KIR genes

Zhongguo shuxue zazhi
Objective To establish a method for qualitative detection of the presence or absence of all KIR genes by quantitative polymerase chain reaction(Q-PCR). Methods Based on the polymorphism of high-resolution level KIR alleles in Chinese population and the ...
Yunan LI, Jianxin ZHEN, Shuang LIANG, Qiong YU, Zhihui DENG   +4 more
doaj   +1 more source

Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak, Ashley D. Westerfield, Vardhman Kumar, Kasturi Chakraborty, Navaneeth Krishna Rajeeva Pandian, Christopher S. Chen, Sangeeta N. Bhatia   +6 more
wiley   +1 more source

The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin

Annals of Neurology, Volume 99, Issue 6, Page 1394-1404, June 2026.
Objectives The objective of this study was to elucidate differences in the cumulative incidence of Leucine‐rich repeat kinase 2 (LRRK2) p.Gly2019Ser‐related Parkinson's disease (PD; LRRK2‐PD) between ancestries and countries. Methods We included 922 unrelated p.Gly2019Ser variant carriers (affected = 762 and unaffected = 160) from the Global Parkinson ...
Theresa Lüth, Björn‐Hergen Laabs, Sebastian Sendel, Inke R. König, Amke Caliebe, Alastair J. Noyce, Laurel A. Screven, Soraya Bardien, Matthew Farrer, Faycel Hentati, Rim Amouri, Christine Klein, Samia Ben Sassi, Joanne Trinh, Global Parkinson's Genetics Program (GP2)   +14 more
wiley   +1 more source

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, EarlyView.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source

Kv7 and K2P Potassium Channels in Thalamocortical Function and Their Therapeutic Potential in Childhood Absence Epilepsy

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Modulation of K2P and Kv7 channels has the potential to reduce hyperexcitability and hypersynchronicity within the thalamocortical system. This offers a new avenue to suppress spike and wave discharges, the electrophysiological hallmark of absence epilepsy.
Anushka Takhi, Guiscard Seebohm, Thomas Budde, Annika Lüttjohann   +3 more
wiley   +1 more source

High‐Intensity Interval Training Boosts Immune Cells in Advanced Cancer Patients and Healthy Controls: Implications for Cancer Care

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Regular exercise improves quality of life (QoL) and reduces fatigue in advanced cancer patients (ACP), but acute immune responses are underexplored. This study investigated the effects of a single high‐intensity interval training (HIIT) session on natural killer (NK) cells and circulating innate lymphoid cells (cILCs) in ACP ...
Fabian Kiehl, Nico De Lazzari, Ronja Beller, Isabella Deppe, Sabrina B. Bennstein, Suzan Botzenhardt, Maria Rosa Salvador Comino, Mitra Tewes, Miriam Götte   +8 more
wiley   +1 more source

KORELASI KEGIATAN EKSTRAKURIKULER KELOMPOK ILMIAH REMAJA (KIR) DENGAN KEMAMPUAN LITERASI INFORMASI

BIBLIOTIKA: Jurnal Kajian Perpustakaan dan Informasi, 2017
Penelitian ini bertujuan mengukur kualitas kegiatan ekstrakurikuler KIR siswa, kemampuan literasi informasi siswa, dan hubungan kualitas kegiatan ekstrakurikuler KIR dengan kemampuan literasi informasi siswa.
Pungky Septiriani, Muakibatul Hasanah
doaj   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Follicular lymphoma patients with KIR2DL2 and KIR3DL1 and their ligands (HLA-C1 and HLA-Bw4) show improved outcome when receiving rituximab

Journal for ImmunoTherapy of Cancer, 2019
Background The ECOG-ACRIN Cancer Research Group evaluated rituximab treatment schedules for patients with newly-diagnosed low-tumor-burden follicular-lymphoma (FL). All patients received 4-weekly rituximab treatments as induction therapy.
Amy K. Erbe, Wei Wang, Lakeesha Carmichael, Anna Hoefges, Bartosz Grzywacz, Patrick K. Reville, Erik A. Ranheim, Jacquelyn A. Hank, KyungMann Kim, Songwon Seo, Eneida A. Mendonca, Yiqiang Song, Vaishalee P. Kenkre, Fangxin Hong, Randy D. Gascoyne, Elisabeth Paietta, Sandra J. Horning, Jeffrey S. Miller, Brad Kahl, Paul M. Sondel   +19 more
doaj   +1 more source