Results 71 to 80 of about 181,399 (228)

The isotopic composition of methane in the stratosphere : high-altitude balloon sample measurements [PDF]

, 2011
The isotopic composition of stratospheric methane has been determined on a large suite of air samples from stratospheric balloon flights covering subtropical to polar latitudes and a time period of 16 yr.
Borchers, Reinhard, Brass, Marc, Engel, Andreas, Röckmann, Thomas   +3 more
core   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, EarlyView.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Decidability of Multi-modal Logic LTK of Linear Time and Knowledge [PDF]

, 2013
Thepaperinvestigates modal(temporal-model) logicsbased at a semantic approach with models combining knowledge and time. We introduce multi-modal logics LT Kr and LT Kir containing modalities for knowledge and time as the sets of all LT Kr -valid, and LT ...
Lukyanchuk, Alexandra N., Лукьянчук, Александра Н.   +1 more
core  

Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution [PDF]

, 2016
Killer-cell immunoglobulin-like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on natural killer (NK) cells, which have dual roles: (1) in fighting infection and (2) in reproduction ...
Chazara, Olympe, Gupta, Sunetra, Moffett, Ashley, Parham, Peter, Penman, Bridget S.   +4 more
core   +3 more sources

Design and Validation of a Multiplex KIR and HLA Class I Genotyping Method Using Next Generation Sequencing

Frontiers in Immunology, 2018
Killer cell immunoglobulin-like receptors (KIR), considered the most polymorphic natural killer (NK) cell regulators, bind HLA class-I molecules or still unknown ligands.
Laia Closa, Laia Closa, Francisco Vidal, Francisco Vidal, Francisco Vidal, Maria J. Herrero, Jose L. Caro, Jose L. Caro   +7 more
doaj   +1 more source

Low CD4+ T cell counts among African HIV-1 infected subjects with group B KIR haplotypes in the absence of specific inhibitory KIR ligands. [PDF]

PLoS ONE, 2011
Natural killer (NK) cells are regulated by interactions between polymorphic killer immunoglobulin-like receptors (KIR) and human leukocyte antigens (HLA).
Wim Jennes, Sonja Verheyden, Christian Demanet, Joris Menten, Bea Vuylsteke, John N Nkengasong, Luc Kestens   +6 more
doaj   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction. [PDF]

, 2015
Allogeneic individuals co-exist during pregnancy in eutherian mammals. Maternal and fetal cells intermingle at the site of placental attachment in the uterus, where the arteries are remodeled to supply the fetus with oxygen and nutrients.
Abi-Rached, Abi-Rached, Adams, Alecsandru, Allan, Apps, Apps, Apps, Apps, Apps, Apps, Banchereau, Bashirova, Beziat, Beziat, Boyson, Brosens, Brusilovsky, Bulmer, Carter, Cavalli-Sforza, Chakraborty, Chan, Civetta, Clements, Cnattingius, Colucci, Cooley, Dekker, Dixon, Ferry, Fischer, Founds, Fuchs, Gendzekhadze, Goodier, Goulopoulou, Grimwood, Gruss, Gundling, Hanna, Heatley, Hiby, Hiby, Hiby, Hiby, Hickey, Hilton, Horowitz, Hublin, Jiang, Khong, Kieckbusch, King, King, Klungsoyr, Kupka, Lash, Llano, Madeja, Male, Male, Mancusi, Marti, Medawar, Mina, Mincheva-Nilsson, Moffett, Moore, Moradi, Moraitis, Moretta, Nakimuli, Nakimuli, Older Aguilar, Opdahl, Parham, Parham, Petrie, Pyo, Pyzik, Rajagopalan, Ristich, Ruggeri, Shachar, Sharkey, Shiroishi, Shiroishi, Sleiman, Thomopoulos, Trevathan, Valdes, Wilkens, Wittman, Xiong   +94 more
core   +2 more sources

Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population

Innate Immunity, 2023
Killer cell immunoglobulin-like receptors (KIR) exhibit extensive diversity, giving rise to different KIR profiles in populations worldwide. This study aimed to investigate the distribution of KIR genes and HLA ligands in a population from Campinas ...
Daniela Maira Cardozo, Amanda Vansan Marangon, Fernando Guimarães, Silvia Marques, Sofia Lieber, Márcia Delamain, Francisco Aranha, Jeane Eliete Laguila Visentainer, Cármino Antonio de Souza   +8 more
doaj   +1 more source

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source