Results 41 to 50 of about 38,491 (220)

New Screening System for Selective Blockers of Voltage-Gated K+ Channels Using Recombinant Cell Lines Dying Upon Single Action Potential

Journal of Pharmacological Sciences, 2013
To develop a simple screening system for blockers of voltage-gated Kv1.3 and Kv1.5 channels, new cell lines co-expressing mutated Nav1.5 (IFM/Q3), Kir2.1 (Kir), and Kv1.3 or Kv1.5 were introduced as IFM/Q3+Kir+Kv1.3 and IFM/Q3+Kir+Kv1.5, respectively ...
Masato Fujii, Keisuke Hayashi, Susumu Ohya, Hisao Yamamura, Yuji Imaizumi   +4 more
doaj   +1 more source

KIR-HLA compound genotype distribution.

, 2018
KIR-HLA compound genotype distribution.
Yonghong Zhang (20918), Sarah Rowland-Jones (74678), Keyi Xu (3147606), Linghang Wang (428108), Tao Dong (15551), Louis-Marie Yindom (4600834)   +5 more
core   +1 more source

Особливості розподілу та частота KIR-генів у жінок із регулярними ранніми репродуктивними втратами

Фактори експериментальної еволюції організмів, 2017
Aim. KIR (killer cell immunoglobulin-like receptors) are the transmembranous glycoprotein receptors, role of which is to activate or inhibit the functional activity of cells, the surfaces of which they are located on.
O. I. Terpyliak, D. V. Zastavna, N. V. Helner, S. V. Osidach   +3 more
doaj   +1 more source

Distribution of Killer-Cell Immunoglobulin-Like Receptor Genes and Combinations of Their Human Leucocyte Antigen Ligands in 11 Ethnic Populations in China

Cells, 2019
The aim of this study was to analyze the distribution of killer-cell immunoglobulin-like receptor (KIR) genes and their human leucocyte antigen (HLA) ligand combinations in different original ethnic populations in China, and thus, to provide relevant ...
Yufeng Yao, Lei Shi, Jiankun Yu, Shuyuan Liu, Yufen Tao, Li Shi   +5 more
doaj   +1 more source

Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and Disease

Frontiers in Cell and Developmental Biology, 2022
Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health. Failure to control potassium balance results in disease, including cardiac arrythmias and developmental disorders.
Natalie A. Hager, Ceara K. McAtee, Mitchell A. Lesko, Allyson F. O’Donnell   +3 more
doaj   +1 more source

4 th INTERNATIONAL CONFERENCE ON ORGANIC AGRICULTURE IN MEDITERRANEAN CLIMATES: THREATS AND SOLUTIONS [PDF]

, 2022
Because of the pandemic Coronavirus (COVID-19) cases, 4th IFOAM AgriBioMediterraneo (IFOAM ABM) Conference on Organic Agriculture and 11th Ecology İzmir Fair activities were postponed in 2020 to a later date. After 2 years, the Ecology fair organized
Cömert Acar, Muazzez, Kir, Alev
core   +1 more source

Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method

Cell Genomics, 2022
Summary: The killer cell immunoglobulin-like receptor (KIR) recognizes human leukocyte antigen (HLA) class I molecules and modulates the function of natural killer cells.
Saori Sakaue, Kazuyoshi Hosomichi, Jun Hirata, Hirofumi Nakaoka, Keiko Yamazaki, Makoto Yawata, Nobuyo Yawata, Tatsuhiko Naito, Junji Umeno, Takaaki Kawaguchi, Toshiyuki Matsui, Satoshi Motoya, Yasuo Suzuki, Hidetoshi Inoko, Atsushi Tajima, Takayuki Morisaki, Koichi Matsuda, Yoichiro Kamatani, Kazuhiko Yamamoto, Ituro Inoue, Yukinori Okada   +20 more
doaj   +1 more source

A federated framework for speech-based early detection of Alzheimer’s disease

Advances in Computing and Engineering
The development of artificial intelligence for Alzheimer’s disease (AD) diagnostics is often hindered by data privacy regulations that prevent the aggregation of sensitive patient information.
Mohamed Mourad Abdellattif, Abdelrahman Mohamed Farouk, Nada Hamada Ahmed, Nadine Ahmed Elquersh, Ahmed Hamdy Elshennawy, Noha S. Tawfik   +5 more
doaj   +1 more source

Effect of shaft eccentricity on dynamic characteristics for different geometries of stationary labyrinth seals

Alexandria Engineering Journal, 2020
The present paper introduces a theoretical study carried out to investigate the effect of shaft lateral misalignment on the dynamic characteristics of labyrinth seals under stationary conditions.
E. Saber, Khaled M. Abdou, R. Afify
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source