Results 41 to 50 of about 23,418 (184)

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Molecular Study of Iraqi Patients with Brain Tumors Infection with HTLV-1

Medical Journal of Babylon
Background: HTLV-1 is associated with the chronic, persistent infection of T cells, which can result in neoplastic or inflammatory diseases; HTLV-1 indirectly damages the central nervous system to cause associated neuropathies starting with the virus ...
Ataa Khalil Al-Shamari, Shakir H. Mohammed Al-Alwany   +1 more
doaj   +1 more source

Effect of shaft eccentricity on dynamic characteristics for different geometries of stationary labyrinth seals

Alexandria Engineering Journal, 2020
The present paper introduces a theoretical study carried out to investigate the effect of shaft lateral misalignment on the dynamic characteristics of labyrinth seals under stationary conditions.
E. Saber, Khaled M. Abdou, R. Afify
doaj   +1 more source

A KIR-TLR connection

Blood, 2010
Killer immunoglobulin-like receptors (KIRs) are well-known for binding human leukocyte antigen (HLA) and allowing natural killer (NK) cells to monitor HLA levels on host cells. Unexpectedly, Sivori and colleagues have found that certain KIRs can also bind microbial nucleic acid and deliver it ...
openaire   +3 more sources

The extensive polymorphism of KIR genes [PDF]

Immunology, 2009
SummaryThe functions of human natural killer (NK) cells are controlled by diverse families of antigen receptors. Prominent among these are the killer cell immunoglobulin‐like receptors (KIR), a family of genes clustered in one of the most variable regions of the human genome.
Derek, Middleton, Faviel, Gonzelez
openaire   +2 more sources

Learning curve of Versius‐assisted radical prostatectomy: role of prior experience and proctoring

BJU International, EarlyView.
Objective To assess the learning curve for radical prostatectomy (RP) with the Versius system (CMR Surgical, Cambridge, UK) and evaluate the transfer of skills from previous robotic and laparoscopic practice. Subjects, Patients and Methods This prospective cohort study included patients with localised prostate cancer undergoing Versius‐assisted RP ...
Guillermo Fernández‐Conejo, Claudia González Álvarez, Pedro Del Olmo Durán, Ana Tagalos Muñoz, Enrique Sanz Mayayo, Víctor Diez Nicolás, Silvia García Barreras, Jose Daniel Subiela Henríquez, Rafael Rodríguez‐Patrón, Elia Pérez‐Fernández, Victoria Gómez Dos Santos, Francisco Javier Burgos Revilla   +11 more
wiley   +1 more source

Composite marginal likelihood estimation of higher‐order diagnostic classification models under high dimensionality

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Although full‐information maximum likelihood (FIML) estimation is widely used for diagnostic classification models (DCMs), its computational efficiency deteriorates sharply in high‐dimensional settings. This scalability challenge is increasingly critical as DCMs are applied to large‐scale assessments, psychological testing and longitudinal ...
Minho Lee, Yon Soo Suh
wiley   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Evaluation of the association between KIR polymorphisms and systemic sclerosis: a meta-analysis

Advances in Rheumatology, 2020
Background The results of investigations on the association between killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and the risk of systemic sclerosis (SSc) are inconsistent.
Elham Karimizadeh, Shayan Mostafaei, Saeed Aslani, Farhad Gharibdoost, Ricardo Machado Xavier, Patricia Hartstein Salim, Hoda Kavosi, Elham Farhadi, Mahdi Mahmoudi   +8 more
doaj   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source