Results 1 to 10 of about 15,494 (227)
KIR Receptors as Key Regulators of NK Cells Activity in Health and Disease
Cells, 2021 Natural killer (NK) cells are part of the cellular immune response. They target mainly cancer and virally infected cells. To a high extent cytotoxic activity of NK cells is regulated inter alia by signals from killer immunoglobulin-like receptors (KIR ...
Maciej Zielinski +2 more
exaly +6 more sources
Immunological Aspects of Infertility—The Role of KIR Receptors and HLA-C Antigen
Cells, 2023 The mechanisms of immune tolerance of a mother against an antigenically foreign fetus without a concomitant loss of defense capabilities against pathogens are the factors underlying the success of a pregnancy.
Anna Wasilewska +5 more
doaj +4 more sources
Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell Transplantation [PDF]
CellsThis paper conducts a literature review on the role of natural killer cells in haploidentical hematopoietic stem cell transplantation. Theoretical concepts related to KIR genes are introduced regarding their structure, nomenclature, genetic organization,
Mar Luis-Hidalgo +3 more
doaj +2 more sources
Journal of Hematology and Oncology, 2016 Background Interim positron emission tomography after 2 cycles of ABVD (iPET-2) is a good predictor of outcome in advanced-stage classic Hodgkin lymphoma.
Roberto Littera +2 more
exaly +3 more sources
Recruitment of activation receptors at inhibitory NK cell immune synapses. [PDF]
PLoS ONE, 2008 Natural killer (NK) cell activation receptors accumulate by an actin-dependent process at cytotoxic immune synapses where they provide synergistic signals that trigger NK cell effector functions.
Nicolas Schleinitz +2 more
doaj +1 more source
KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans
Cell Reports, 2023 Summary: Subsets of the human CD8+ T cell population express inhibitory NK cell receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A.
Seong Jin Choi +7 more
doaj +1 more source
Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells. [PDF]
PLoS Genetics, 2010 Natural killer (NK) cells serve essential functions in immunity and reproduction. Diversifying these functions within individuals and populations are rapidly-evolving interactions between highly polymorphic major histocompatibility complex (MHC) class I ...
Laurent Abi-Rached +4 more
doaj +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Hypoglossal nerve stimulation is an effective treatment option for obstructive sleep apnea (OSA) in positive airway pressure therapy failure. Nonetheless, data regarding the functional effect of modifying stimulation parameters within each electrode configuration are limited.
Armin Steffen +4 more
wiley +1 more source
Natural killer cell receptor genes in the family Equidae: not only Ly49. [PDF]
PLoS ONE, 2013 Natural killer (NK) cells have important functions in immunity. NK recognition in mammals can be mediated through killer cell immunoglobulin-like receptors (KIR) and/or killer cell lectin-like Ly49 receptors.
Jan Futas, Petr Horin
doaj +1 more source
The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. [PDF]
PLoS Biology, 2006 The majority of receptors responsible for activation of distinct cell types within the immune system assemble with dimeric signaling modules through interaction of a basic transmembrane residue with a pair of acidic residues of the signaling dimer ...
Jianwen Feng +2 more
doaj +1 more source