Results 1 to 10 of about 26,234 (229)
Iranian Journal of Allergy, Asthma and Immunology, 2017 After kidney transplantation, natural killer (NK) cells play a pivotal role in triggering the immune response to the allogeneic grafts primarily by their killer-cell immunoglobulin-like receptors (KIR).
Davood Jafari +6 more
doaj
Phylogenetics, Niche Evolution, and Distribution Dynamics of Isatis Species Under Climate Change
Ecology and Evolution, Volume 16, Issue 5, May 2026.This study systematically elucidates the adaptive evolution of Isatis species from the perspective of life‐history strategies and niche evolution, highlights the increased extinction risk faced by wild relatives, and provides a critical scientific basis for the conservation and sustainable use of the germplasm resources of this genus.
Min Wei +4 more
wiley +1 more source
Manufacturing and clinical applications of non‐CAR‐T immune effector cells
Transfusion, EarlyView.
Thane Kubik +2 more
wiley +1 more source
Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy
MedComm, Volume 7, Issue 5, May 2026.Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley +1 more source
Two to Tango: Co-evolution of Hominid Natural Killer Cell Receptors and MHC
Frontiers in Immunology, 2019 Natural killer (NK) cells have diverse roles in hominid immunity and reproduction. Modulating these functions are the interactions between major histocompatibility complex (MHC) class I molecules that are ligands for two NK cell surface receptor types ...
Emily E. Wroblewski +2 more
doaj +1 more source
Opening closed inward rectifier potassium channel doors
British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger +3 more
wiley +1 more source
Fisheries Trade and Blue Nutrient Flows in Pacific Island Countries
Fish and Fisheries, Volume 27, Issue 3, Page 466-477, May 2026.ABSTRACT Pacific Island Countries (PICs) are located in highly productive fishing regions that supply nutrient‐rich fish to global markets. Marine fisheries are a critical source of protein and essential micronutrients for billions of people worldwide, supporting both local diets and global food security.
Keiko J. Nomura +3 more
wiley +1 more source
Frontiers in Immunology, 2013 Natural Killer (NK) cells whose killer immunoglobulin-like receptors (KIR) recognize human leukocyte antigen (HLA) ligand are licensed for activity. In contrast, non-licensed NK cells display KIRs for which ligand is absent from the self genotype and ...
Carolyn E. Behrendt +3 more
doaj +1 more source
Innate ImmunityBackground Killer immunoglobulin-like receptors (KIRs) are key molecules used by natural killer (NK) cells to interact with target cells. These receptors exhibit extensive genotypic polymorphism which has been associated with varying outcomes in immune ...
Jameel Al-Tamimi +3 more
doaj +1 more source
Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]
, 2019 The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike +10 more
core +1 more source