KIR Receptors as Key Regulators of NK Cells Activity in Health and Disease
Cells, 2021 Natural killer (NK) cells are part of the cellular immune response. They target mainly cancer and virally infected cells. To a high extent cytotoxic activity of NK cells is regulated inter alia by signals from killer immunoglobulin-like receptors (KIR ...
Piotr Trzonkowski +2 more
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Immunological Aspects of Infertility—The Role of KIR Receptors and HLA-C Antigen
Cells, 2023 The mechanisms of immune tolerance of a mother against an antigenically foreign fetus without a concomitant loss of defense capabilities against pathogens are the factors underlying the success of a pregnancy.
Anna Wasilewska +5 more
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Global patterns of KIR genotype diversity reflect human migration and regional differences [PDF]
Frontiers in ImmunologyBackgroundKiller-cell immunoglobulin-like receptors (KIR) are highly polymorphic receptors expressed by natural killer (NK) cells that regulate immune responses through interactions with HLA class I ligands.
Shaghik Barani +5 more
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Killer-cell immunoglobulin-like receptors define a potent effector program in human γδ T cells [PDF]
JCI InsightHuman γδ T cells are a rare but functionally diverse lymphocyte subset critical for tumor surveillance and antimicrobial immunity. Although they express NK cell–associated receptors such as killer-cell immunoglobulin-like receptors (KIRs), the relevance ...
Mahya Razmi +5 more
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Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans. [PDF]
PLoS Genetics, 2013 Interactions between HLA class I molecules and killer-cell immunoglobulin-like receptors (KIR) control natural killer cell (NK) functions in immunity and reproduction.
Paul J Norman +9 more
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Recruitment of activation receptors at inhibitory NK cell immune synapses. [PDF]
PLoS ONE, 2008 Natural killer (NK) cell activation receptors accumulate by an actin-dependent process at cytotoxic immune synapses where they provide synergistic signals that trigger NK cell effector functions.
Nicolas Schleinitz +2 more
doaj +1 more source
KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans
Cell Reports, 2023 Summary: Subsets of the human CD8+ T cell population express inhibitory NK cell receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A.
Seong Jin Choi +7 more
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Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells. [PDF]
PLoS Genetics, 2010 Natural killer (NK) cells serve essential functions in immunity and reproduction. Diversifying these functions within individuals and populations are rapidly-evolving interactions between highly polymorphic major histocompatibility complex (MHC) class I ...
Laurent Abi-Rached +4 more
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Natural killer cell receptor genes in the family Equidae: not only Ly49. [PDF]
PLoS ONE, 2013 Natural killer (NK) cells have important functions in immunity. NK recognition in mammals can be mediated through killer cell immunoglobulin-like receptors (KIR) and/or killer cell lectin-like Ly49 receptors.
Jan Futas, Petr Horin
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The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. [PDF]
PLoS Biology, 2006 The majority of receptors responsible for activation of distinct cell types within the immune system assemble with dimeric signaling modules through interaction of a basic transmembrane residue with a pair of acidic residues of the signaling dimer ...
Jianwen Feng +2 more
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