Results 21 to 30 of about 26,234 (229)

Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells. [PDF]

PLoS Genetics, 2010
Natural killer (NK) cells serve essential functions in immunity and reproduction. Diversifying these functions within individuals and populations are rapidly-evolving interactions between highly polymorphic major histocompatibility complex (MHC) class I ...
Laurent Abi-Rached, Achim K Moesta, Raja Rajalingam, Lisbeth A Guethlein, Peter Parham   +4 more
doaj   +1 more source

Killer cell immunoglobulin-like receptor (KIR) genes in systemic sclerosis [PDF]

Clinical and Experimental Immunology, 2010
Summary A previous study has suggested that the combination KIR2DS2+/KIR2DL2- was related to increased risk for systemic sclerosis (SSc), while others have failed to reproduce this finding. Our objective was to study this matter further and test the association of other KIR genes with SSc. One hundred and ten SSc patients and 115 healthy
P H, Salim, M, Jobim, M, Bredemeier, J A B, Chies, J, Schlottfeldt, J C T, Brenol, L F, Jobim, R M, Xavier   +7 more
openaire   +2 more sources

Natural killer cell receptor genes in the family Equidae: not only Ly49. [PDF]

PLoS ONE, 2013
Natural killer (NK) cells have important functions in immunity. NK recognition in mammals can be mediated through killer cell immunoglobulin-like receptors (KIR) and/or killer cell lectin-like Ly49 receptors.
Jan Futas, Petr Horin
doaj   +1 more source

Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans. [PDF]

PLoS Genetics, 2013
Interactions between HLA class I molecules and killer-cell immunoglobulin-like receptors (KIR) control natural killer cell (NK) functions in immunity and reproduction.
Paul J Norman, Jill A Hollenbach, Neda Nemat-Gorgani, Lisbeth A Guethlein, Hugo G Hilton, Marcelo J Pando, Kwadwo A Koram, Eleanor M Riley, Laurent Abi-Rached, Peter Parham   +9 more
doaj   +1 more source

Impulse Configuration in Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea: The Effect of Modifying Pulse Width and Frequency

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Hypoglossal nerve stimulation is an effective treatment option for obstructive sleep apnea (OSA) in positive airway pressure therapy failure. Nonetheless, data regarding the functional effect of modifying stimulation parameters within each electrode configuration are limited.
Armin Steffen, Stephanie Jeschke, Ryan J. Soose, Katrin Hasselbacher, Inke R. König   +4 more
wiley   +1 more source

The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. [PDF]

PLoS Biology, 2006
The majority of receptors responsible for activation of distinct cell types within the immune system assemble with dimeric signaling modules through interaction of a basic transmembrane residue with a pair of acidic residues of the signaling dimer ...
Jianwen Feng, Matthew E Call, Kai W Wucherpfennig   +2 more
doaj   +1 more source

Killer-Cell Immunoglobulin-like Receptor Diversity in an Admixed South American Population

Cells, 2022
Natural Killer (NK) cells are innate immune cells that mediate antiviral and antitumor responses. NK cell activation and induction of effector functions are tightly regulated by the integration of activating and inhibitory receptors such as killer ...
Marlon Castrillon, Nancy D. Marin, Amado J. Karduss-Urueta, Sonia Y. Velasquez, Cristiam M. Alvarez   +4 more
doaj   +1 more source

Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis [PDF]

Human Immunology, 2014
Genes encoding KIRs vary in frequency among different populations and ethnic groups. This study investigated the KIR gene frequency distribution in 148 healthy unrelated Saudi subjects and compared the results with other published findings. All inhibitory and activating KIR genes were present at variable frequencies, with A haplotype-associated genes ...
Osman, Awad E, Mubasher, Mohamed, ElSheikh, Nezar E, AlHarthi, Hanan, Yami, Ahmed S Al, Rajalingam, Raja, Al-Dehaimi, Abdulwahid, Middleton, Derek, ElGhazali, Gehad   +8 more
openaire   +4 more sources

High-Resolution Analysis Identifies High Frequency of KIR-A Haplotypes and Inhibitory Interactions of KIR With HLA Class I in Zhejiang Han

Frontiers in Immunology, 2021
Killer cell immunoglobulin-like receptors (KIR) interact with human leukocyte antigen (HLA) class I molecules, modulating critical NK cell functions in the maintenance of human health.
Sudan Tao, Yanmin He, Katherine M. Kichula, Jielin Wang, Ji He, Paul J. Norman, Faming Zhu   +6 more
doaj   +1 more source

Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia [PDF]

, 2017
Interactions between killer-immunoglobulin-like receptors (KIRs) and their HLA class I ligands are instrumental in natural killer (NK) cell regulation and protect normal tissue from NK cell attack.
Aurelius, J., Bernson, E., Brune, M., Foà, R., Hallner, A., Hellstrand, K., Kiffin, R., Martner, A., Rydström, A., Sander, F. E., Thorén, F. B., Werlenius, O., Wilsson, O.   +12 more
core   +1 more source