Effects of peptide on NK cell-mediated MHC I recognition
Frontiers in Immunology, 2014 The inhibitory receptors for MHC class I have a central role in controlling NK cell activity. Soon after their discovery it was found that these receptors have a degree of peptide selectivity.
Salim Iqbal Khakoo +2 more
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Identification and diversity of killer cell Ig-like receptors in Aotus vociferans, a New World monkey. [PDF]
PLoS ONE, 2013 Previous BAC clone analysis of the Platyrrhini owl monkey KIRs have shown an unusual genetic structure in some loci. Therefore, cDNAs encoding KIR molecules from eleven Aotus vociferans monkeys were characterized here; ten putative KIR loci were found ...
Diego Garzón-Ospina +4 more
doaj +1 more source
G Protein-Coupled Receptor Signaling to Kir Channels in Xenopus Oocytes [PDF]
Current Pharmaceutical Biotechnology, 2014 Kir3 (or GIRK) channels have been known for nearly three decades to be activated by direct interactions with the βγ subunits of heterotrimeric G (Gαβγ) proteins in a membrane-delimited manner. Gα also interacts with GIRK channels and since PTX-sensitive Gα subunits show higher affinity of interaction they confer signaling specificity to G Protein ...
Candice, Hatcher-Solis +10 more
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Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients
Mediators of Inflammation, 2020 We investigated activation status, cytotoxic potential, and gut homing ability of the peripheral blood Natural Killer (NK) cells in Crohn disease (CD) patients. For this purpose, we compared the expression of different activating and inhibitory receptors
Suzanne Samarani +7 more
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Evolution of NK receptors: a single Ly49 and multiple KIR genes in the cow [PDF]
European Journal of Immunology, 2002 Natural killer (NK) cell receptors for classical MHC class I molecules are encoded by the killer Ig-like receptor (KIR) multigene family in humans and other primates. Mouse NK cells, however, employ a completely different multigene family, the C-type lectin-like Ly49 genes, to perform the same function.
Karina L, McQueen +3 more
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The Structure, Evolution, and Gene Expression Within the Caprine Leukocyte Receptor Complex
Frontiers in Immunology, 2019 The leukocyte receptor complex (LRC) encodes a large number of immunoglobulin (Ig)-like receptors involved in the immune response, particularly in modulating natural killer (NK) cell function.
John C. Schwartz +5 more
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Analysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE
BMC Biology, 2022 Background Natural killer (NK) cells represent a critical component of the innate immune system’s response against cancer and viral infections, among other diseases.
Galen F. Gao +3 more
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Natural Killer Cells Offer Differential Protection From Leukemia in Chinese Southern Han
Frontiers in Immunology, 2019 Interactions of human natural killer (NK) cell inhibitory receptors with polymorphic HLA-A, -B and -C molecules educate NK cells for immune surveillance against tumor cells. The KIR A haplotype encodes a distinctive set of HLA-specific NK cell inhibiting
Zhihui Deng +20 more
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Killer Cell Immunoglobulin-Like Receptors (KIR) Typing by DNA Sequencing [PDF]
, 2012 DNA sequencing is a powerful technique for identifying allelic variation within the natural killer cell immunoglobulin-like receptor genes. Because of the relatively large size of the KIR genes, each locus is amplified in two or more overlapping segments.
Lihua, Hou +5 more
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A novel system of polymorphic and diverse NK cell receptors in primates.
PLoS Genetics, 2009 There are two main classes of natural killer (NK) cell receptors in mammals, the killer cell immunoglobulin-like receptors (KIR) and the structurally unrelated killer cell lectin-like receptors (KLR).
Anne Averdam +18 more
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