Results 41 to 50 of about 560,467 (222)

Immunorecognition of leukemic stem cells by NK cells : the role of HDAC inhibitors in NKG2D ligand-mediated anti-tumor responses in acute myeloid leukemia [PDF]

, 2008
The diagnosis of acute myeloid leukemia (AML) is associated to a poor long-term outcome due to frequent relapse despite intensive chemotherapy, radiation and hematopoietic stem cell transplantation (HSCT) as well as continuous advances in treatment ...
Langenkamp, Ulrich
core   +1 more source

A novel system of polymorphic and diverse NK cell receptors in primates.

PLoS Genetics, 2009
There are two main classes of natural killer (NK) cell receptors in mammals, the killer cell immunoglobulin-like receptors (KIR) and the structurally unrelated killer cell lectin-like receptors (KLR).
Anne Averdam, Beatrix Petersen, Cornelia Rosner, Jennifer Neff, Christian Roos, Manfred Eberle, Fabienne Aujard, Claudia Münch, Werner Schempp, Mary Carrington, Takashi Shiina, Hidetoshi Inoko, Florian Knaust, Penny Coggill, Harminder Sehra, Stephan Beck, Laurent Abi-Rached, Richard Reinhardt, Lutz Walter   +18 more
doaj   +1 more source

Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes [PDF]

The Journal of Immunology, 2015
Abstract The human killer cell Ig-like receptor (KIR) locus comprises two groups of KIR haplotypes, termed A and B. These are present in all human populations but with different relative frequencies, suggesting they have different functional properties that underlie their balancing selection.
Hugo G Hilton, Lisbeth A Guethlein, Ana Goyos, Neda Nemat-Gorgani, David A Bushnell, Paul J Norman, Peter Parham   +6 more
openaire   +2 more sources

Design and Validation of a Multiplex KIR and HLA Class I Genotyping Method Using Next Generation Sequencing

Frontiers in Immunology, 2018
Killer cell immunoglobulin-like receptors (KIR), considered the most polymorphic natural killer (NK) cell regulators, bind HLA class-I molecules or still unknown ligands.
Laia Closa, Laia Closa, Francisco Vidal, Francisco Vidal, Francisco Vidal, Maria J. Herrero, Jose L. Caro, Jose L. Caro   +7 more
doaj   +1 more source

Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis [PDF]

Human Immunology, 2014
Genes encoding KIRs vary in frequency among different populations and ethnic groups. This study investigated the KIR gene frequency distribution in 148 healthy unrelated Saudi subjects and compared the results with other published findings. All inhibitory and activating KIR genes were present at variable frequencies, with A haplotype-associated genes ...
Osman, Awad E, Mubasher, Mohamed, ElSheikh, Nezar E, AlHarthi, Hanan, Yami, Ahmed S Al, Rajalingam, Raja, Al-Dehaimi, Abdulwahid, Middleton, Derek, ElGhazali, Gehad   +8 more
openaire   +4 more sources

Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell Transplantation

Cells
This paper conducts a literature review on the role of natural killer cells in haploidentical hematopoietic stem cell transplantation. Theoretical concepts related to KIR genes are introduced regarding their structure, nomenclature, genetic organization,
Mar Luis-Hidalgo, José Luis Piñana, Carlos Solano, Dolores Planelles   +3 more
doaj   +1 more source

KIR genotype distribution among patients with chronic lymphocytic leukemia: Is there a role for KIR 2DS4 and KIR 2DS5 genes? [PDF]

, 2016
Introduction The function of natural killer (NK) cells is regulated by different antigen receptors including killer immunoglobulin-like receptors (KIR). In addition to their important role in fighting infection, natural killer cells produce cytotoxicity ...
Hoteit, Rouba M., Shammaa, Dina M.R., Antar, Ahmad I., Mahfouz, Rami A.R., Bazarbachi, Ali Abdul Hamid, Salem, Ziad M.   +5 more
core   +1 more source

Evolution of natural killer cell receptors coexistence of functional Ly49 and KIR genes in baboons [PDF]

, 2001
Natural killer (NK) cells represent an important first line of defense against viruses and malignancy [1]. NK cells express a variety of inhibitory and activating receptors that interact with classical major histocompatibility complex (MHC) class I ...
Wee, Vinnie, Freeman, J.Douglas, J.Douglas Freeman, McQueen, Karina L, Dixie L Mager, Mager, Dixie L, Karina L McQueen, Vinnie Wee   +7 more
core   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Functional Repurposing of Magnetic Nanoparticle‐Assisted Hyperthermia for Immune Cell Labelling and Tracking

Small Methods, EarlyView.
We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino   +8 more
wiley   +1 more source