Results 41 to 50 of about 26,234 (229)

The Structure, Evolution, and Gene Expression Within the Caprine Leukocyte Receptor Complex

Frontiers in Immunology, 2019
The leukocyte receptor complex (LRC) encodes a large number of immunoglobulin (Ig)-like receptors involved in the immune response, particularly in modulating natural killer (NK) cell function.
John C. Schwartz, Nicholas D. Sanderson, Nicholas D. Sanderson, Derek M. Bickhart, Timothy P. L. Smith, John A. Hammond   +5 more
doaj   +1 more source

Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]

, 2015
Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni, Biron, Björklund, Brodin, Bryceson, Burns, Campbell, Cooley, Cooper, Cooper, Curti, Davies, Di Santo, Di Santo, Farag, Fehniger, Fogler, Foley, Freud, Gasser, Gilfillan, Grimm, Guethlein, Herberman, Huntington, Joncker, Kiessling, Killig, King, Kröger, Lajoie, Lanier, Leong, Ljunggren, Lowe, Lundqvist, Mancusi, McQueen, Miller, Moretta, Moretta, Moretta, Nguyen, Oevermann, Ouyang, Perussia, Phillips, Romagnani, Romee, Rosenberg, Rosenberg, Rosenberg, Ruggeri, Santoni, Stabile, Stabile, Stern, Stringaris, Thielens, Torelli, Trinchieri, Trinchieri, Vago, Valés-Gómez, Venstrom, Vivier, Whitelaw, Zorn   +67 more
core   +1 more source

Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy. [PDF]

, 2019
Natural killer (NK) cells of the innate immune system are a key focus of research within the field of immuno-oncology based on their ability to recognize and eliminate malignant cells without prior sensitization or priming.
Canter, Robert J, Gingrich, Alicia A, Modiano, Jaime F   +2 more
core   +2 more sources

Natural Killer Cells Offer Differential Protection From Leukemia in Chinese Southern Han

Frontiers in Immunology, 2019
Interactions of human natural killer (NK) cell inhibitory receptors with polymorphic HLA-A, -B and -C molecules educate NK cells for immune surveillance against tumor cells. The KIR A haplotype encodes a distinctive set of HLA-specific NK cell inhibiting
Zhihui Deng, Jun Zhao, Siqi Cai, Ying Qi, Qiong Yu, Maureen P. Martin, Xiaojiang Gao, Rui Chen, Jiacai Zhuo, Jianxin Zhen, Jianxin Zhen, Mingjie Zhang, Guobin Zhang, Liumei He, Hongyan Zou, Liang Lu, Weigang Zhu, Wenxu Hong, Mary Carrington, Mary Carrington, Paul J. Norman   +20 more
doaj   +1 more source

Analysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE

BMC Biology, 2022
Background Natural killer (NK) cells represent a critical component of the innate immune system’s response against cancer and viral infections, among other diseases.
Galen F. Gao, Dajiang Liu, Xiaowei Zhan, Bo Li   +3 more
doaj   +1 more source

Simple models of the chemical field around swimming plankton [PDF]

, 2010
Background. Cervical cancer is the fourth most common cancer in women, and we recently reported human leukocyte antigen (HLA) alleles showing strong associations with cervical neoplasia risk and protection.
Bao, Xiao,, Brown, Matthew A.,, Castro, Felipe,, Cortes, Adrian,, Coutlée, François,, Cremin, Katie,, Cruickshank, Maggie,, Duncan, Emma L.,, Franco, Eduardo L.,, Frazer, Ian H.,, Garland, Suzanne M.,, Hanson, Aimee L.,, Hemminki, Kari,, Hildesheim, Allan,, Johnson, Lisa G.,, Leo, Paul J.,, Little, Julian,, Lund University., Lund University., Madeleine, Margaret M.,, Marshall, Mhairi,, Mukhopadhyay, Pamela,, Newell, Felicity,, Ohlsson, Claes,, Pettersson-Kymmer, Ulrika,, Rader, Janet S.,, Safaeian, Mahboobeh,, Schwartz, Stephen M.,, Sitas, Freddy,, Steinberg, Winfried,, Sun, Ying Pu,, Tabrizi, Sepehr N.,, Tiews, Sven,, Trimble, Cornelia,, Wang, Sophia S.,, Wentzensen, Nicolas,   +35 more
core   +2 more sources

Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress. [PDF]

, 2018
Neurotransmitter switching in the adult mammalian brain occurs following photoperiod-induced stress, but the mechanism of regulation is unknown. Here, we demonstrate that elevated activity of dopaminergic neurons in the paraventricular nucleus of the ...
Deisseroth, Karl, Leutgeb, Stefan, Li, Hui-Quan, Meng, Da, Spitzer, Nicholas C   +4 more
core   +1 more source

'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. [PDF]

, 2010
Natural killer (NK) cells expressing inhibitory receptors that bind to self major histocompatibility complex (MHC) class I are 'licensed', or rendered functionally more responsive to stimulation, whereas 'unlicensed' NK cells lacking receptors for self ...
Lanier, Lewis L, Murphy, William J, Orr, Mark T   +2 more
core   +3 more sources

Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes [PDF]

The Journal of Immunology, 2015
Abstract The human killer cell Ig-like receptor (KIR) locus comprises two groups of KIR haplotypes, termed A and B. These are present in all human populations but with different relative frequencies, suggesting they have different functional properties that underlie their balancing selection.
Hugo G Hilton, Lisbeth A Guethlein, Ana Goyos, Neda Nemat-Gorgani, David A Bushnell, Paul J Norman, Peter Parham   +6 more
openaire   +2 more sources

A novel system of polymorphic and diverse NK cell receptors in primates.

PLoS Genetics, 2009
There are two main classes of natural killer (NK) cell receptors in mammals, the killer cell immunoglobulin-like receptors (KIR) and the structurally unrelated killer cell lectin-like receptors (KLR).
Anne Averdam, Beatrix Petersen, Cornelia Rosner, Jennifer Neff, Christian Roos, Manfred Eberle, Fabienne Aujard, Claudia Münch, Werner Schempp, Mary Carrington, Takashi Shiina, Hidetoshi Inoko, Florian Knaust, Penny Coggill, Harminder Sehra, Stephan Beck, Laurent Abi-Rached, Richard Reinhardt, Lutz Walter   +18 more
doaj   +1 more source