Results 61 to 70 of about 15,494 (227)

Low CD4+ T cell counts among African HIV-1 infected subjects with group B KIR haplotypes in the absence of specific inhibitory KIR ligands. [PDF]

PLoS ONE, 2011
Natural killer (NK) cells are regulated by interactions between polymorphic killer immunoglobulin-like receptors (KIR) and human leukocyte antigens (HLA).
Wim Jennes, Sonja Verheyden, Christian Demanet, Joris Menten, Bea Vuylsteke, John N Nkengasong, Luc Kestens   +6 more
doaj   +1 more source

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

Natural killer cells and cancer: Regulation by the killer cell Ig-like receptors (KIR) [PDF]

Cancer Biology & Therapy, 2009
Natural killer (NK) cells are innate immune effector cells that make up approximately 10-15% of the peripheral blood lymphocytes in humans and are primarily involved in immunosurveillance to eliminate transformed and virally-infected cells. They were originally defined by their ability to spontaneously eliminate rare cells lacking expression of class I
Amanda K. PURDY, Kerry S. CAMPBELL
openaire   +4 more sources

Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population

Innate Immunity, 2023
Killer cell immunoglobulin-like receptors (KIR) exhibit extensive diversity, giving rise to different KIR profiles in populations worldwide. This study aimed to investigate the distribution of KIR genes and HLA ligands in a population from Campinas ...
Daniela Maira Cardozo, Amanda Vansan Marangon, Fernando Guimarães, Silvia Marques, Sofia Lieber, Márcia Delamain, Francisco Aranha, Jeane Eliete Laguila Visentainer, Cármino Antonio de Souza   +8 more
doaj   +1 more source

NK cells and KIR receptors: their importance in haematopoietic stem cell transplantations in leukemia [PDF]

, 2019
NK cells and KIR receptors: their importance in haematopoietic stem cell transplantations in leukemia Abstract This bachelor thesis discusses the importance of NK (natural-killer) cells in leukemias. It focuses on the structure and reactivity of NK cells,
Ledvinková, Anna
core  

The Turkey Ig-like receptor family: identification, expression and function. [PDF]

, 2012
The chicken leukocyte receptor complex located on microchromosome 31 encodes the chicken Ig-like receptors (CHIR), a vastly expanded gene family which can be further divided into three subgroups: activating CHIR-A, bifunctional CHIR-AB and inhibitory ...
Windau, Katharina, Birgit C Viertlboeck, Birgit C. Viertlboeck, Thomas W Göbel, Thomas W. Göbel, Viertlboeck, Birgit C., Göbel, Thomas W. F., Katharina Windau   +7 more
core   +1 more source

The impact of KIR/HLA genes on the risk of developing multibacillary leprosy. [PDF]

PLoS Neglected Tropical Diseases, 2019
BACKGROUND:Killer-cell immunoglobulin-like receptors (KIRs) are a group of regulatory molecules able to activate or inhibit natural killer cells upon interaction with human leukocyte antigen (HLA) class I molecules.
Hugo Vicentin Alves, Amarilis Giaretta de Moraes, Afonso Carrasco Pepineli, Bruna Tiaki Tiyo, Quirino Alves de Lima Neto, Thais da Silva Santos, Jorge Juarez Vieira Teixeira, Eliane P Ambrosio-Albuquerque, Ana Maria Sell, Jeane Eliete Laguila Visentainer   +9 more
doaj   +1 more source

Evolution of natural killer cell receptors coexistence of functional Ly49 and KIR genes in baboons

, 2001
Natural killer (NK) cells represent an important first line of defense against viruses and malignancy [1]. NK cells express a variety of inhibitory and activating receptors that interact with classical major histocompatibility complex (MHC) class I ...
Wee, Vinnie, Freeman, J.Douglas, J.Douglas Freeman, McQueen, Karina L, Dixie L Mager, Mager, Dixie L, Karina L McQueen, Vinnie Wee   +7 more
core   +1 more source

Natural killer cell immunity after transplantation

Swiss Medical Weekly, 2012
Transplantation immunology has traditionally focused on adaptive, i.e., T- and B-cell reactions. More recently, natural killer (NK) cells were also recognised as playing an important role after transplantation of solid organs and haematopoietic ...
Grzegorz Terszowski, Jakob R Passweg, Martin Stern   +2 more
doaj   +1 more source

Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis

Frontiers in Immunology, 2021
Killer cell immunoglobulin-like receptors (KIR) regulate immune responses in NK and CD8+ T cells via interaction with HLA ligands. KIR genes, including KIR2DS1, KIR3DL1, and KIR3DS1 have previously been implicated in psoriasis susceptibility.
Richard Ahn, Richard Ahn, Damjan Vukcevic, Damjan Vukcevic, Damjan Vukcevic, Allan Motyer, Allan Motyer, Joanne Nititham, David McG. Squire, David McG. Squire, Jill A. Hollenbach, Paul J. Norman, Eva Ellinghaus, Rajan P. Nair, Lam C. Tsoi, Lam C. Tsoi, Lam C. Tsoi, Jorge Oksenberg, John Foerster, Wolfgang Lieb, Stephan Weidinger, Andre Franke, James T. Elder, James T. Elder, Eric Jorgenson, Stephen Leslie, Stephen Leslie, Stephen Leslie, Wilson Liao   +28 more
doaj   +1 more source