Results 71 to 80 of about 26,234 (229)

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Interactions between purinergic receptors and Kir channels in neurovascular coupling

The FASEB Journal, 2010
We previously noted a large overlap in the contributions from adenosine (ADO) and K + ‐ channels in the process of neurovascular coupling (NVC), implying the presence of interactive mechanisms.
Haoliang Xu, Francesco Vetri, Lizhen Mao, Dale A. Pelligrino   +3 more
openaire   +1 more source

Ligand specificity of Killer cell Immunoglobulin-like Receptors: a brief history of KIR [PDF]

Frontiers in Immunology, 2012
Natural Killer (NK) cells are a subset of innate lymphoid cells specialized for cytotoxicity and production of inflammatory cytokines such as IFNγ. As such, they are presumed to be important for early control of infections with intracellular pathogens and anti-tumor immunity. In addition, NK cells may help to regulate placentation.
van Bergen, Jeroen, Trowsdale, John
openaire   +3 more sources

Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population

Innate Immunity, 2023
Killer cell immunoglobulin-like receptors (KIR) exhibit extensive diversity, giving rise to different KIR profiles in populations worldwide. This study aimed to investigate the distribution of KIR genes and HLA ligands in a population from Campinas ...
Daniela Maira Cardozo, Amanda Vansan Marangon, Fernando Guimarães, Silvia Marques, Sofia Lieber, Márcia Delamain, Francisco Aranha, Jeane Eliete Laguila Visentainer, Cármino Antonio de Souza   +8 more
doaj   +1 more source

Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. [PDF]

, 1996
The killer cell inhibitory receptors (KIRs) are surface glycoproteins expressed by natural killer (NK) and T cells that specifically recognize defined groups of polymorphic human histocompatibility leukocyte antigen (HLA) class I molecules.
Chang, C, D'Andrea, A, Lanier, LL, Phillips, JH   +3 more
core  

CO2-dependent opening of an inwardly rectifying K+ channel [PDF]

, 2011
CO2 chemosensing is a vital function for the maintenance of life that helps to control acid–base balance. Most studies have reported that CO2 is measured via its proxy, pH. Here we report an inwardly rectifying channel, in outside-out excised patches
Huckstepp, Robert T. R., Dale, Nicholas
core   +1 more source

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source

Identification of the ancestral killer immunoglobulin-like receptor gene in primates

BMC Genomics, 2006
Background Killer Immunoglobulin-like Receptors (KIR) are essential immuno-surveillance molecules. They are expressed on natural killer and T cells, and interact with human leukocyte antigens.
Coggill Penny, Vernikos George S, Piatak Mike, Andersen Hanne, Bashirova Arman, Sambrook Jennifer G, Lifson Jeff D, Carrington Mary, Beck Stephan   +8 more
doaj   +1 more source

Non-classical immunology. Meeting Report [PDF]

, 2001
This large annual immunology meeting covered a wide range of subjects from biochemical protein characterizations to cell biology and the study of complex disease pathologies.
Allen, RL
core   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source