Results 71 to 80 of about 15,494 (227)

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes

, 2003
Using monoclonal antibodies (mAbs) specific for different natural killer (NK) receptors, we studied the lymphocyte population from 18 patients with NK-type lymphoproliferative disease of granular lymphocytes (LDGL).
ZAMBELLO R, TRENTIN L, SEMENZATO G, AGOSTINI, CARLO, CASTRICONI R, CASTRICONI, ROBERTA, FALCO M, CARLOMAGNO S, CAROLLO D, CARLOMAGNO, SIMONA, SEMENZATO, GIANPIETRO CARLO, CANNAS G, VITALE M., MORETTA, ALESSANDRO, DELLA CHIESA M, DELLA CHIESA, MARIELLA, CABRELLE A, CABRELLE, ANNA, MORETTA A, ZAMBELLO, RENATO, TRENTIN, LIVIO, LAMY T, AGOSTINI C   +22 more
core   +1 more source

Extensive Alternative Splicing of KIR Transcripts

Frontiers in Immunology, 2018
The killer-cell Ig-like receptors (KIR) form a multigene entity involved in modulating immune responses through interactions with MHC class I molecules.
Jesse Bruijnesteijn, Marit K. H. van der Wiel, Nanine de Groot, Nel Otting, Annemiek J. M. de Vos-Rouweler, Neubury M. Lardy, Natasja G. de Groot, Ronald E. Bontrop, Ronald E. Bontrop   +8 more
doaj   +1 more source

Extensive variation in gene copy number at the killer immunoglobulin-like receptor locus in humans. [PDF]

PLoS ONE, 2013
Killer immunoglobulin-like receptors (KIRs) are involved in the regulation of natural killer cell cytotoxicity. Within the human genome seventeen KIR genes are present, which all contain a large number of allelic variants.
Sanne Vendelbosch, Martin de Boer, Remko A T W Gouw, Cynthia K Y Ho, Judy Geissler, Wendy T N Swelsen, Michael J Moorhouse, Neubury M Lardy, Dirk Roos, Timo K van den Berg, Taco W Kuijpers   +10 more
doaj   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

KIR genotypic diversity in Portuguese and analysis of KIR gene allocation after allogeneic hematopoietic stem cell transplantation

, 2016
The diversity of killer-cell immunoglobulin-like receptors (KIR) genes was evaluated in Portuguese and the observed genotypic profiles were found related to the ones reported in European populations.
Sanchez-Mazas, Alicia, Ligeiro, D., Buhler, Stéphane, Trindade, H., da Silva, M. Gomes, Abecasis, M., Abade, O.   +6 more
core   +1 more source

KIR genotype distribution among patients with multiple myeloma: Higher prevalence of KIR 2DS4 and KIR 2DS5 genes [PDF]

, 2014
Introduction: Natural killer (NK) cells possess an antitumor activity against multiple myeloma cells proven by the susceptibility of plasmocytes to NK lysis. In the early stage of MM, the killing of MM cells is mediated by natural cytotoxicity receptors (
Hoteit, Rouba M., Shammaa, Dina M.R., Antar, Ahmad I., Mahfouz, Rami A.R., Bazarbachi, Ali Abdul Hamid, Salem, Ziad M.   +5 more
core   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Molecular determinant-based typing of KIR alleles and KIR ligands

, 2011
Killer cell immunoglobulin-like receptors (KIRs) regulate NK cell function. KIRs and their HLA ligands are highly polymorphic in nature with substantial allelic polymorphism.
Rafijul Bari, Christy Embrey, Wing Leung, Victoria E. Turner, Matthias Leung, Martha Holladay, Bari, Rafijul, Barbara Rooney, Turner, Victoria E., Leung, Matthias, Holladay, Martha, Rooney, Barbara, Embrey, Christy, Leung, Wing   +13 more
core   +1 more source