Results 81 to 90 of about 560,467 (222)

Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response

OncoImmunology, 2021
The antibody-dependent cellular cytotoxicity (ADCC) effector function of natural killer (NK) cells is one of the known mechanisms of action for rituximab-based anti-cancer immunotherapy.
Dhon Roméo Makanga, Maxime Jullien, Gaëlle David, Nolwenn Legrand, Catherine Willem, Léa Dubreuil, Alexandre Walencik, Cyrille Touzeau, Thomas Gastinne, Benoit Tessoulin, Steven Le Gouill, Béatrice Mahé, Katia Gagne, Patrice Chevallier, Béatrice Clemenceau, Christelle Retière   +15 more
doaj   +1 more source

NK cells and KIR receptors: their importance in haematopoietic stem cell transplantations in leukemia [PDF]

, 2019
NK cells and KIR receptors: their importance in haematopoietic stem cell transplantations in leukemia Abstract This bachelor thesis discusses the importance of NK (natural-killer) cells in leukemias. It focuses on the structure and reactivity of NK cells,
Ledvinková, Anna
core  

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

The favorable role of homozygosity for killer immunoglobulin-like receptor (KIR) A haplotype in patients with advanced-stage classic Hodgkin lymphoma

Journal of Hematology & Oncology, 2016
Background Interim positron emission tomography after 2 cycles of ABVD (iPET-2) is a good predictor of outcome in advanced-stage classic Hodgkin lymphoma.
Giorgio La Nasa, Marianna Greco, Roberto Littera, Sara Oppi, Ivana Celeghini, Rossella Caria, Sara Lai, Rita Porcella, Massimo Martino, Alessandra Romano, Francesco Di Raimondo, Andrea Gallamini, Carlo Carcassi, Giovanni Caocci   +13 more
doaj   +1 more source

Extensive variation in gene copy number at the killer immunoglobulin-like receptor locus in humans. [PDF]

PLoS ONE, 2013
Killer immunoglobulin-like receptors (KIRs) are involved in the regulation of natural killer cell cytotoxicity. Within the human genome seventeen KIR genes are present, which all contain a large number of allelic variants.
Sanne Vendelbosch, Martin de Boer, Remko A T W Gouw, Cynthia K Y Ho, Judy Geissler, Wendy T N Swelsen, Michael J Moorhouse, Neubury M Lardy, Dirk Roos, Timo K van den Berg, Taco W Kuijpers   +10 more
doaj   +1 more source

Efficacy of sodium channel blockers in treating myotonia is independent of action potential sodium current block

The Journal of Physiology, EarlyView.
Abstract figure legend Contrary to the prevailing view, the therapeutic efficacy of sodium channel blockers in myotonia does not depend on inhibition of the transient sodium current (NaT) responsible for action potentials. In a mouse model of myotonia congenita, effective concentrations of sodium channel blockers did not reduce NaT, but consistently ...
Phil Walker, Brent Foy, Xueyong Wang, Kaylee M. Pham, Jess Myers, Chris Dupont, Samantha Kohli, Adam S. Deardorff, Andrew A. Voss, Mark M. Rich   +9 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

KIR-expressing CD8⁺ T cells bind HLA-C-multimers epitope-independently.

, 2018
(A) Exemplary depiction of KIR-expression on CD8+ T cells by KIR2DL2/3 staining. (B) Multimer staining of CD8+ T cells for the indicated epitopes and overlay of multimer+ CD8+ T cells (blue) and KIR2DL2/3 staining (grey).
Michael Neuenhahn (168944), Dirk H. Busch (125319), Volker Hösel (3701041), Stefan Dreher (168926), Uwe Heemann (285995), Fabian Schlott (414947), Dominik Steubl (3159330), Stefanie Ameres (414946), Andreas Moosmann (38220)   +8 more
core   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, Volume 41, Issue 10, Page 1105-1118, October 2026.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source