Results 101 to 110 of about 26,234 (229)

Role of KIR3DS1 in Human Diseases [PDF]

, 2012
The function of natural killer (NK) cells is controlled by several activating and inhibitory receptors, including the family of killer-immunoglobulin-like receptors (KIRs).
Altfeld, Marcus, Körner, Christian
core   +2 more sources

Evolution of Killer Cell Ig-Like Receptor (KIR) Genes: Definition of an Orangutan KIR Haplotype Reveals Expansion of Lineage III KIR Associated with the Emergence of MHC-C [PDF]

The Journal of Immunology, 2007
Abstract Orangutan (Pongo pygmaeus) MHC-C appears less evolved than human HLA-C: Popy-C is not fixed and its alleles encode only one (C1) of the two motifs for killer cell Ig-like receptor (KIR) ligands. To assess the structure and complexity of the orangutan KIR locus, the complete nucleotide sequence of an orangutan KIR haplotype was ...
Lisbeth A, Guethlein, Anastazia M, Older Aguilar, Laurent, Abi-Rached, Peter, Parham   +3 more
openaire   +2 more sources

Distribution of killer cell immunoglobulin-like receptors genes in the Italian Caucasian population

Journal of Translational Medicine, 2006
Background Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activatory receptors that are expressed by most natural killer (NK) cells. The KIR gene family is polymorphic: genomic diversity is achieved through differences in
Mariani M, Malagoli A, Lombardo C, Iannone AM, Frison S, Dametto E, Cosentini E, Chiesa A, Carcassi C, Martinetti M, Cuccia MC, Testi M, Bontadini A, Mariotti L, Mascaretti L, Mele L, Miotti V, Nesci S, Ozzella G, Piancatelli D, Romeo G, Tagliaferri C, Vatta S, Andreani M, Conte R   +24 more
doaj   +1 more source

Ligula intestinalis (Cestoda: Pseudophyllidea): an ideal fish-metazoan parasite model? [PDF]

, 2010
Since its use as a model to study metazoan parasite culture and in vitro development, the plerocercoid of the tapeworm, Ligula intestinalis, has served as a useful scientific tool to study a range of biological factors, particularly within its fish ...
Carter, V, Dufour, S, Hoole, D
core   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Killer Ig-Like Receptor (KIR) Genotype Predicts the Capacity of Human KIR-Positive CD56dim NK Cells to Respond to Pathogen-Associated Signals [PDF]

The Journal of Immunology, 2009
Abstract IFN-γ emanating from NK cells is an important component of innate defense against infection. In this study, we demonstrate that, following in vitro stimulation of human peripheral blood NK cells with a variety of microbial ligands, CD56dim as well as CD56bright NK cells contribute to the overall NK cell IFN-γ response with, for ...
Daniel S, Korbel, Paul J, Norman, Kirsty C, Newman, Amir, Horowitz, Ketevan, Gendzekhadze, Peter, Parham, Eleanor M, Riley   +6 more
openaire   +2 more sources

Killer Cell Immunoglobulin-like Receptors and their Ligands [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2010
The Natural killer (NK) cells are a subset of lymphocytes comprising around 10% of total lymphocytes in peripheral blood. Due to their role in the innate response, NK cells provide a ‘first line of defense’ against infectious agents and cancer and are ...
Tajik N., Shahsavar F., Entezami K.
doaj   +2 more sources

Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction. [PDF]

, 2015
Allogeneic individuals co-exist during pregnancy in eutherian mammals. Maternal and fetal cells intermingle at the site of placental attachment in the uterus, where the arteries are remodeled to supply the fetus with oxygen and nutrients.
Abi-Rached, Abi-Rached, Adams, Alecsandru, Allan, Apps, Apps, Apps, Apps, Apps, Apps, Banchereau, Bashirova, Beziat, Beziat, Boyson, Brosens, Brusilovsky, Bulmer, Carter, Cavalli-Sforza, Chakraborty, Chan, Civetta, Clements, Cnattingius, Colucci, Cooley, Dekker, Dixon, Ferry, Fischer, Founds, Fuchs, Gendzekhadze, Goodier, Goulopoulou, Grimwood, Gruss, Gundling, Hanna, Heatley, Hiby, Hiby, Hiby, Hiby, Hickey, Hilton, Horowitz, Hublin, Jiang, Khong, Kieckbusch, King, King, Klungsoyr, Kupka, Lash, Llano, Madeja, Male, Male, Mancusi, Marti, Medawar, Mina, Mincheva-Nilsson, Moffett, Moore, Moradi, Moraitis, Moretta, Nakimuli, Nakimuli, Older Aguilar, Opdahl, Parham, Parham, Petrie, Pyo, Pyzik, Rajagopalan, Ristich, Ruggeri, Shachar, Sharkey, Shiroishi, Shiroishi, Sleiman, Thomopoulos, Trevathan, Valdes, Wilkens, Wittman, Xiong   +94 more
core   +2 more sources

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion. [PDF]

, 2013
Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins.
Ameres, Stefanie, Busch, Dirk H., Mautner, Josef, Moosmann, Andreas, Neuenhahn, Michael, Plachter, Bodo, Schlott, Fabian   +6 more
core   +3 more sources