Results 101 to 110 of about 15,494 (227)

Killer Cell Immunoglobulin-like Receptors (KIR) and Human Leucocyte Antigen C (HLA-C) Increase the Risk of Long-Term Chronic Liver Graft Rejection. [PDF]

Int J Mol Sci, 2022
Legaz I, Bolarín JM, Campillo JA, Moya-Quiles MR, Miras M, Muro M, Minguela A, Álvarez-López MR.   +7 more
europepmc   +1 more source

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, Volume 67, Issue 6, Page 3226-3242, June 2026.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source

KIR on the cusp of modern immunogenetics

, 2017
Killer Immunoglobulin-like Receptors (KIR) and their Human Leukocyte Antigen (HLA) ligands play a central role in immunity and human health. These molecules are encoded by gene families with copy number variation, extreme levels of sequence diversity and

core   +1 more source

Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA

Tissue Antigens, 2010
The killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop (IHIWS) sought to explore worldwide population variation in the KIR loci, and to examine the relationship between KIR genes and their human leukocyte antigen (HLA) ligands. Fifteen laboratories submitted KIR genotype and HLA ligand
J A, Hollenbach, A, Meenagh, C, Sleator, C, Alaez, M, Bengoche, A, Canossi, G, Contreras, L, Creary, I, Evseeva, C, Gorodezky, R-A, Hardie, T Hemming, Karlsen, B, Lie, M, Luo, M, Martinetti, C, Navarette, D C M, de Oliveira, G, Ozzella, A, Pasi, E, Pavlova, S, Pinto, L C, Porto, P, Santos, A, Slavcev, D, Srinak, S, Tavoularis, S, Tonks, E, Trachtenberg, S, Vejbaesya, D, Middleton   +29 more
openaire   +5 more sources

Effect of NK cell receptor genetic variation on allogeneic stem cell transplantation outcome and in vitro NK cell cytotoxicity

Scientific Reports
Natural killer (NK) cells recognize and may kill malignant cells via their cell surface receptors. Killer cell immunoglobulin-like receptor (KIR) genotypes of donors have been reported to adjust the risk of relapse after allogeneic stem cell ...
Julia Nihtilä, Leena Penna, Urpu Salmenniemi, Maija Itälä-Remes, Rachel E. Crossland, David Gallardo, Katarzyna Bogunia-Kubik, Piotr Lacina, Maria Bieniaszewska, Sebastian Giebel, Katariina Karjalainen, Farhana Jahan, Erja Kerkelä, Kati Hyvärinen, Satu Koskela, Jarmo Ritari, Jukka Partanen   +16 more
doaj   +1 more source

Killer Immunoglobulin-like Receptors (KIR) and their HLA-ligands in Italian Paroxysmal Nocturnal Haemoglobinuria (PNH) patients

, 2012
PNH is a haematopoietic disorder characterized by expansion of PIG-A-defective progenitor(s). Immune-dependent mechanisms, likely involving a deranged T-cell-dependent autoimmune response have been consistently associated with the selection/dominance of
RUGGIERO, GIUSEPPINA, TERRAZZANO, Giuseppe, RISITANO, ANTONIO MARIA, Carmine Garzillo, Fiorella Alfinito, Giuseppe Terrazzano, GARZILLO, CARMINE, ALFINITO, FIORELLA, Michela Sica, Giuseppina Ruggiero, Rosalba Camerlingo, Martina Serrab, Rosario Notaro, Elena Cosentini, Martina Serra, Umberto Giani, COSENTINI, ELENA, GIANI, UMBERTO, Vincenza Luongo, Paolo Bruno, Sonia Lastraioli, Lucia Gargiulo, Antonio Risitano   +22 more
core   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Investigation of Killer Immunoglobulin-like Receptor (KIR) and HLA Genotypes to Predict the Occurrence of Acute Allograft Rejection after Kidney Transplantation

Iranian Journal of Allergy, Asthma and Immunology, 2017
After kidney transplantation, natural killer (NK) cells play a pivotal role in triggering the immune response to the allogeneic grafts primarily by their killer-cell immunoglobulin-like receptors (KIR).
Davood Jafari, Mohsen Nafar, Mir Saeed Yekaninejad, Razieh Abdolvahabi, Mahboob Lesan Pezeshki, Efat Razaghi, Ali Akbar Amirzargar   +6 more
doaj  

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Influence of human leukocyte antigen (HLA) alleles and killer cell immunoglobulin-like receptors (KIR) types on heparin-induced thrombocytopenia (HIT) [PDF]

, 2017
Objectives Heparin-induced thrombocytopenia (HIT) is an unpredictable, life-threatening, immune-mediated reaction to heparin. Variation in human leukocyte antigen (HLA) genes is now used to prevent immune-mediated adverse drug reactions. Combinations of
Roden, Dan M, Rebecca Pavlos, Pavlos, Rebecca, Cronin, Robert, Gaudieri, S., Jason H. Karnes, Mosley, J.D., James, Ian, Phillips, E.J., Mosley, Jonathan D, Lisa Bastarache, Heidi E. Steiner, Robert Cronin, Shaffer, C.M., Shaffer, Christian M, Karnes, J.H., Karnes, Jason H, Bastarache, Lisa, Silvana Gaudieri, Elizabeth J. Phillips, Steiner, H., Pavlos, R., Christian M. Shaffer, Jonathan D. Mosley, Denny, Joshua C, Dan M. Roden, Bastarache, L., Ian James, Joshua C. Denny, Simon Mallal, Mallal, Simon, Cronin, R., Denny, J.C., Phillips, Elizabeth J, James, I., Gaudieri, Silvana, Steiner, Heidi E, Mallal, S., Roden, D.M.   +38 more
core   +1 more source