Results 101 to 110 of about 560,467 (222)

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis.

PLoS Genetics, 2020
The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells, are a collection of highly polymorphic activating and inhibitory receptors with variable specificity for class I human ...
Aimee L Hanson, International Genetics of Ankylosing Spondylitis Consortium, Damjan Vukcevic, Stephen Leslie, Jessica Harris, Kim-Anh Lê Cao, Tony J Kenna, Matthew A Brown   +7 more
doaj   +1 more source

Molecular determinant-based typing of KIR alleles and KIR ligands

, 2011
Killer cell immunoglobulin-like receptors (KIRs) regulate NK cell function. KIRs and their HLA ligands are highly polymorphic in nature with substantial allelic polymorphism.
Rafijul Bari, Christy Embrey, Wing Leung, Victoria E. Turner, Matthias Leung, Martha Holladay, Bari, Rafijul, Barbara Rooney, Turner, Victoria E., Leung, Matthias, Holladay, Martha, Rooney, Barbara, Embrey, Christy, Leung, Wing   +13 more
core   +1 more source

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, EarlyView.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source

Effect of NK cell receptor genetic variation on allogeneic stem cell transplantation outcome and in vitro NK cell cytotoxicity

Scientific Reports
Natural killer (NK) cells recognize and may kill malignant cells via their cell surface receptors. Killer cell immunoglobulin-like receptor (KIR) genotypes of donors have been reported to adjust the risk of relapse after allogeneic stem cell ...
Julia Nihtilä, Leena Penna, Urpu Salmenniemi, Maija Itälä-Remes, Rachel E. Crossland, David Gallardo, Katarzyna Bogunia-Kubik, Piotr Lacina, Maria Bieniaszewska, Sebastian Giebel, Katariina Karjalainen, Farhana Jahan, Erja Kerkelä, Kati Hyvärinen, Satu Koskela, Jarmo Ritari, Jukka Partanen   +16 more
doaj   +1 more source

When Neck Pain Is Bleeding: Spontaneous Cervical Epidural Hematoma Case Following Recent Binge Alcohol Intake

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Spontaneous cervical epidural hematoma should be suspected in patients with acute neck pain and stroke‐like neurological deficits. We report a 36‐year‐old man managed conservatively after early neurological improvement. Initial cervical MRI demonstrated a posterior epidural mass‐like lesion, whereas serial MRI demonstrated progressive ...
Selkin Yılmaz Muluk, Sacide Efsun Ürger, Sevcan Uğur, Öykü Sude Kır   +3 more
wiley   +1 more source

Investigation of Killer Immunoglobulin-like Receptor (KIR) and HLA Genotypes to Predict the Occurrence of Acute Allograft Rejection after Kidney Transplantation

Iranian Journal of Allergy, Asthma and Immunology, 2017
After kidney transplantation, natural killer (NK) cells play a pivotal role in triggering the immune response to the allogeneic grafts primarily by their killer-cell immunoglobulin-like receptors (KIR).
Davood Jafari, Mohsen Nafar, Mir Saeed Yekaninejad, Razieh Abdolvahabi, Mahboob Lesan Pezeshki, Efat Razaghi, Ali Akbar Amirzargar   +6 more
doaj  

Parallel processing of T cells and natural killer cells to enhance in vivo CAR T cell activity against blood and solid cancers

Clinical &Translational Immunology, Volume 15, Issue 9, 2026.
Abstract Objectives Despite their anti‐cancer properties, natural killer (NK) cells are discarded during CAR T cell manufacturing. NK cells display promising responses as a cell therapy, exhibiting remarkable safety at high doses. Moreover, NK cells have complementary cytokine profiles and distinct antigen‐recognition pathways to supplement CAR T cell ...
Lachlan J Dobson, Patrick W Marron, Ariana HT Drabble, Thiloma D Liyanage, Kristine C Pe, Clare Y Slaney, Barry D Hock, Alexander D McLellan   +7 more
wiley   +1 more source

Association of paternal HLA-C and maternal killer-cell immunoglobulin-like receptor genotypes in the development of autism

Frontiers in Pediatrics, 2016
Natural killer (NK) cells belong to the innate immunity system. Their activity is regulated by inhibitory and activating receptors. The major family of inhibitory receptors is the Killer immunoglobulin-like receptors (KIRs) which recognize MHC class I ...
Moriya Gamliel, Karen Anderson, Nurit Yirmiya, Richard Paul Ebstein, David Mankuta   +4 more
doaj   +1 more source

KIR and KIR ligand polymorphism: a new area for clinical applications?

, 2013
Killer immunoglobulin-like receptors (KIRs) play an essential role in the regulation of natural killer (NK) activity, allowing NK cells to sense and respond to human leukocyte antigen (HLA) class I downregulation, an important hallmark for viral ...
C. Bottino, L. Moretta, M. Falco, MORETTA, ALESSANDRO, BOTTINO, CRISTINA, MORETTA, LORENZO, A. Moretta, FALCO, MICHELA   +7 more
core   +1 more source

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 9, Page 1535-1549, September 2026.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source