Results 121 to 130 of about 15,494 (227)

Association of KIR-HLA interactions with diseases

, 2011
The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors which control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene
Tahereh Mousavi, Ali reza Azargoon, Farhad Shahsavar, Kobra Entezami   +3 more
core  

Data_Sheet_1_Extensive Alternative Splicing of KIR Transcripts.PDF

, 2018
The killer-cell Ig-like receptors (KIR) form a multigene entity involved in modulating immune responses through interactions with MHC class I molecules.
Jesse Bruijnesteijn (6038990), Neubury M. Lardy (428707), Ronald E. Bontrop (180007), Nanine de Groot (6038996), Nel Otting (267522), Annemiek J. M. de Vos-Rouweler (6038999), Marit K. H. van der Wiel (6038993), Natasja G. de Groot (301110)   +7 more
core   +1 more source

Mechanisms of Copy Number Variation and Hybrid Gene Formation in the KIR Immune Gene Complex [PDF]

, 2011
The fine-scale structure of the majority of copy number variation (CNV) regions remains unknown. The killer immunoglobulin receptor (KIR) gene complex exhibits significant CNV.
Trowsdale, John, Ohashi, Maki, Carrington, Mary, Pellett, Fawnda, Gladman, Dafna, Martin, Maurice, Ward, Rosemary, Middleton, Derek, Traherne, James A.   +8 more
core   +1 more source

Two Orangutan Species Have Evolved Different KIR Alleles and Haplotypes

, 2017
The immune and reproductive functions of human NK cells are regulated by interactions of the C1 and C2 epitopes of HLA-C with C1-specific and C2-specific lineage III killer cell Ig-like receptors (KIR). This rapidly evolving and diverse system of ligands
Lisbeth A. Guethlein, Ronald E. Bontrop, Paul J. Norman, Farbod Babrzadeh, Laurent Abi-Rached, Hugo G. Hilton, Peter Parham, Corinne M. C. Heijmans, Natasja G. de Groot   +8 more
core   +1 more source

Killer Cell Immunoglobulin-like Receptors and their Ligands

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
<p>The Natural killer (NK) cells are a subset of lymphocytes comprising around 10% of total lymphocytes in peripheral blood. Due to their role in the innate response, NK cells provide a ‘first line of defense’ against infectious agents and cancer ...
F Shahsavar
doaj  

Killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen-C (HLA-C) allorecognition patterns in women with endometriosis. [PDF]

Sci Rep, 2020
Chou YC, Chen CH, Chen MJ, Chang CW, Chen PH, Yu MH, Chen YJ, Tsai EM, Yang PS, Lin SY, Tzeng CR.   +10 more
europepmc   +1 more source

Hanging in the balance: KIR and their role in disease

, 2005
The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors that control natural killer (NK) cell function.
Khakoo, Salim I., Bateman, Andrew R., Williams, Anthony P.   +2 more
core   +1 more source

Activation of group I metabotropic glutamate receptors regulates the excitability of rat retinal ganglion cells by suppressing Kir and Ih

, 2017
Institutes of Brain Science and Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, Shanghai Key Laboratory of Visual Impairment and Restoration, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032 ...
Xue-Yan Li, Zhongfeng Wang, Peng Cui, Qian Li, Wen-Jing Qian, Feng Gao, Yanying Miao, Shu-Xia Jiang, Xing-Huai Sun   +8 more
core  

KIR-mediated NK education mediates KIR-associated Crohn's disease susceptibility

, 2012
Purpose/Objective: Natural Killer (NK) cells are innate effector lymphocytes in the host response to infections and tumors through a variety of activating and inhibitory receptors. NK cells require education by self-human leukocyte antigen (HLA) class
McGovern, Dermot, Targan, Stephan, Ma, C., Aziz, N., Lin, Lin, Rajalingam, Raja, Braun, Jonathan   +6 more
core  

Detailed gene and allele content analysis of three homozygous KIR haplotypes

, 2015
The Killer Immunoglobulin-like Receptors are a highly polymorphic family of receptors encoded by fifteen genes clustered on 19q13.4. Due to the complexity of the genetic analysis of the KIR cluster much of the data regarding KIR sequences and alleles has
Kircheisin, Renate, Seoud, Muheiddine, Mazhar, Batool, Slim, Rima, Murdoch, Sharlene   +4 more
core   +1 more source