Results 111 to 120 of about 26,234 (229)

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

The Xenopus FcR family demonstrates continually high diversification of paired receptors in vertebrate evolution

BMC Evolutionary Biology, 2008
Background Recent studies have revealed an unexpected diversity of domain architecture among FcR-like receptors that presumably fulfill regulatory functions in the immune system.
Najakshin Alexander M, Mechetina Ludmila V, Erilova Aleksandra Y, Ramanayake Thaminda, Guselnikov Sergey V, Robert Jacques, Taranin Alexander V   +6 more
doaj   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

kir‐mapper: A Toolkit for Killer‐Cell Immunoglobulin‐Like Receptor (KIR) Genotyping From Short‐Read Second‐Generation Sequencing Data

HLA
ABSTRACTKiller cell immunoglobulin‐like receptors (KIRs) regulate natural killer (NK) cell responses by activating or inhibiting their functions. Genotyping KIR genes from short‐read second‐generation sequencing data remains challenging as cross‐alignments among genes and alignment failure arise from gene similarities and extreme polymorphism.
Erick C. Castelli, Raphaela Neto Pereira, Gabriela Sato Paes, Heloisa S. Andrade, Marcel Rodrigues Ferreira, Ícaro Scalisse de Freitas Santos, Nicolas Vince, Nicholas R. Pollock, Paul J. Norman, Diogo Meyer   +9 more
openaire   +2 more sources

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis.

PLoS Genetics, 2020
The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells, are a collection of highly polymorphic activating and inhibitory receptors with variable specificity for class I human ...
Aimee L Hanson, International Genetics of Ankylosing Spondylitis Consortium, Damjan Vukcevic, Stephen Leslie, Jessica Harris, Kim-Anh Lê Cao, Tony J Kenna, Matthew A Brown   +7 more
doaj   +1 more source

Haplotype-Based Analysis of KIR-Gene Profiles in a South European Population—Distribution of Standard and Variant Haplotypes, and Identification of Novel Recombinant Structures

Frontiers in Immunology, 2020
Inhibitory Killer-cell Immunoglobulin-like Receptors (KIR) specific for HLA class I molecules enable human natural killer cells to monitor altered antigen presentation in pathogen-infected and tumor cells.
Elisa Cisneros, Manuela Moraru, Natalia Gómez-Lozano, Aura Muntasell, Miguel López-Botet, Miguel López-Botet, Carlos Vilches   +6 more
doaj   +1 more source

A minor high‐grade component in non‐invasive papillary urothelial carcinoma is not associated with a more indolent behaviour

Histopathology, Volume 88, Issue 7, Page 1430-1442, June 2026.
Non‐invasive papillary urothelial carcinomas with minor high‐grade component are not associated with a more indolent behavior and should likely be regarded as high‐grade carcinomas. Aims The latest WHO edition proposed using a cut‐off of ≥5% high‐grade component (%HGc) as a criterion to label non‐invasive papillary urothelial carcinomas as high‐grade ...
Mina S. Farag, Neda Oghbaei, Jaffar Hussain, André Lametti, Wassim Kassouf, Fadi Brimo   +5 more
wiley   +1 more source

CD155 on HIV-infected cells is not modulated by HIV-1 Vpu and Nef but synergizes with NKG2D ligands to trigger NK cell lysis of autologous primary HIV-infected cells [PDF]

, 2017
Activation of primary CD4(+) T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)].
Barker, Edward, Cogswell, Andrew, Davis, Zacharay B, Plannelles, Vincente, Sowriajan, Bharatwaj, Ward, Jeffrey P   +5 more
core   +2 more sources

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Killer Cell Ig-like Receptors (KIR)-Binding Assay for Tumor Cells

BIO-PROTOCOL, 2016
Natural killer (NK) cells play key roles in innate and adaptive immune responses against virus and tumor cells. Their function relies on the dynamic balance between activating and inhibiting signals through receptors that bind ligands expressed on target cells.
Loredana Cifaldi, Franco Locatelli, Doriana Fruci   +2 more
openaire   +2 more sources