Results 91 to 100 of about 15,494 (227)

Kv7 and K2P Potassium Channels in Thalamocortical Function and Their Therapeutic Potential in Childhood Absence Epilepsy

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Modulation of K2P and Kv7 channels has the potential to reduce hyperexcitability and hypersynchronicity within the thalamocortical system. This offers a new avenue to suppress spike and wave discharges, the electrophysiological hallmark of absence epilepsy.
Anushka Takhi, Guiscard Seebohm, Thomas Budde, Annika Lüttjohann   +3 more
wiley   +1 more source

Killer Immunoglobulin-Like Receptor Profiles are not Associated with risk of Amoxicillin-Clavulanate-Induced Liver Injury in Spanish Patients

Frontiers in Pharmacology, 2016
Natural killer cells are an integral part of the immune system and represent a large proportion of the lymphocyte population in the liver. The activity of these cells is regulated by various cell surface receptors, such as killer Ig-like receptors (KIR ...
Camilla Stephens, Antonia Moreno-Casares, Miguel-Ángel López-Nevot, Miren García-Cortés, Inmaculada Medina-Cáliz, Hacibe Hallal, German Soriano, Eva Roman, Eva Roman, Francisco Ruiz-Cabello, Manuel Romero-Gomez, M Isabel Lucena, Raúl J Andrade   +12 more
doaj   +1 more source

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, EarlyView.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source

High‐Intensity Interval Training Boosts Immune Cells in Advanced Cancer Patients and Healthy Controls: Implications for Cancer Care

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Regular exercise improves quality of life (QoL) and reduces fatigue in advanced cancer patients (ACP), but acute immune responses are underexplored. This study investigated the effects of a single high‐intensity interval training (HIIT) session on natural killer (NK) cells and circulating innate lymphoid cells (cILCs) in ACP ...
Fabian Kiehl, Nico De Lazzari, Ronja Beller, Isabella Deppe, Sabrina B. Bennstein, Suzan Botzenhardt, Maria Rosa Salvador Comino, Mitra Tewes, Miriam Götte   +8 more
wiley   +1 more source

Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapse

, 2012
This report describes the clinical courses of two acute myeloid leukemia patients. Both had MLL translocations, the first a t(10;11)(p11.2;q23) with MLL-AF10 and the second a t(11;19)(q23;p13.1) with MLL-ELL fusion.
Meyer, Claus, Carola Tietze-Bürger, Claus Meyer, Igor Blau, Burmeister, Thomas, Molkentin, Mara, Thomas Burmeister, Mara Molkentin, Nils Lachmann, Uharek, Lutz, Rolf Marschalek, Tietze-Bürger, Carola, Friedrichs, Birte, Blau, Igor Wolfgang, Jörg Beyer, Marschalek, Rolf, Schwartz, Stefan, Lutz Uharek, Beyer, Jörg, Stefan Schwartz, Gunnar Lohm, Birte Friedrichs, Lachmann, Nils, Lohm, Gunnar   +23 more
core   +1 more source

Association of paternal HLA-C and maternal killer-cell immunoglobulin-like receptor genotypes in the development of autism

Frontiers in Pediatrics, 2016
Natural killer (NK) cells belong to the innate immunity system. Their activity is regulated by inhibitory and activating receptors. The major family of inhibitory receptors is the Killer immunoglobulin-like receptors (KIRs) which recognize MHC class I ...
Moriya Gamliel, Karen Anderson, Nurit Yirmiya, Richard Paul Ebstein, David Mankuta   +4 more
doaj   +1 more source

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis.

PLoS Genetics, 2020
The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells, are a collection of highly polymorphic activating and inhibitory receptors with variable specificity for class I human ...
Aimee L Hanson, International Genetics of Ankylosing Spondylitis Consortium, Damjan Vukcevic, Stephen Leslie, Jessica Harris, Kim-Anh Lê Cao, Tony J Kenna, Matthew A Brown   +7 more
doaj   +1 more source

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, Volume 67, Issue 6, Page 3199-3210, June 2026.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Autologous and allogeneic HLA KIR ligand environments and activating KIR control KIR NK-cell functions

, 2008
International audienceNK-cell function is regulated by a balance between inhibitory and activating killer cell immunoglobulin-like receptors (KIR) that specifically recognize HLA class I molecules.
Folléa, Gilles, Véronique Sébille, Katia Gagne, Clémenceau, Béatrice, Laure Denis, Gilles Folléa, Béatrice Clémenceau, Maelig Morvan, Morvan, Maelig, Gagne, Katia, Kerdudou, Nolwenn, Aurore Perrin, Denis, Laure, Catherine Willem, Jean-Denis Bignon, Christelle Retière, David, Gaëlle, Perrin, Aurore, Gaëlle David, Nolwenn Kerdudou, Bignon, Jean-Denis, Sébille, Véronique, Retiere, Christelle, Willem, Catherine   +23 more
core   +1 more source

The Xenopus FcR family demonstrates continually high diversification of paired receptors in vertebrate evolution

BMC Evolutionary Biology, 2008
Background Recent studies have revealed an unexpected diversity of domain architecture among FcR-like receptors that presumably fulfill regulatory functions in the immune system.
Najakshin Alexander M, Mechetina Ludmila V, Erilova Aleksandra Y, Ramanayake Thaminda, Guselnikov Sergey V, Robert Jacques, Taranin Alexander V   +6 more
doaj   +1 more source