Results 31 to 40 of about 13,983 (185)
Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes [PDF]
The Journal of Immunology, 2015 Abstract The human killer cell Ig-like receptor (KIR) locus comprises two groups of KIR haplotypes, termed A and B. These are present in all human populations but with different relative frequencies, suggesting they have different functional properties that underlie their balancing selection.
Hugo G Hilton +6 more
openaire +2 more sources
Frontiers in Immunology, 2018 Killer cell immunoglobulin-like receptors (KIR), considered the most polymorphic natural killer (NK) cell regulators, bind HLA class-I molecules or still unknown ligands.
Laia Closa +7 more
doaj +1 more source
Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis [PDF]
Human Immunology, 2014 Genes encoding KIRs vary in frequency among different populations and ethnic groups. This study investigated the KIR gene frequency distribution in 148 healthy unrelated Saudi subjects and compared the results with other published findings. All inhibitory and activating KIR genes were present at variable frequencies, with A haplotype-associated genes ...
Osman, Awad E +8 more
openaire +4 more sources
Expression patterns of killer cell immunoglobulin-like receptors (KIR) of NK-cell and T-cell subsets in Old World monkeys. [PDF]
PLoS ONE, 2013 The expression of killer cell immunoglobulin-like receptors (KIR) on lymphocytes of rhesus macaques and other Old World monkeys was unknown so far.
Meike Hermes +4 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Advanced Science, EarlyView.Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi +9 more
wiley +1 more source
Small Methods, EarlyView.We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci +8 more
wiley +1 more source
Haematologica, 2010 Background Natural killer cell-type lymphoproliferative disease of granular lymphocytes is a disorder characterized by chronic proliferation of CD3−CD16+ granular lymphocytes.
Cristina Gattazzo +13 more
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye +5 more
wiley +1 more source
Ligand specificity of Killer cell Immunoglobulin-like Receptors: a brief history of KIR [PDF]
Frontiers in Immunology, 2012 Natural Killer (NK) cells are a subset of innate lymphoid cells specialized for cytotoxicity and production of inflammatory cytokines such as IFNγ. As such, they are presumed to be important for early control of infections with intracellular pathogens and anti-tumor immunity. In addition, NK cells may help to regulate placentation.
van Bergen, Jeroen, Trowsdale, John
openaire +3 more sources