Results 31 to 40 of about 26,234 (229)
Expression of KIR and C-type lectin receptors in Behcet's disease [PDF]
Rheumatology, 2004 Behçet's disease (BD) is a multisystemic disorder with a possible underlying pathology of immune-mediated vasculitis. Genetic susceptibility associated with HLA-B*51 and B*2702 has been implicated in its pathogenesis. Considering the recently defined regulatory mechanisms of NK cells through HLA class I binding receptors, we hypothesized that ...
Gul, A +8 more
openaire +3 more sources
Revista Brasileira de Reumatologia, 2011 Os genes Killer Immunoglobulin-like Receptors (KIR) expressam-se como receptores que estimulam ou inibem as células Natural Killer (NK). As células NK fazem parte da imunidade inata e através de seus receptores KIR identificam células-alvo que apresentam
Patricia Hartstein Salim +3 more
doaj +1 more source
Identification and diversity of killer cell Ig-like receptors in Aotus vociferans, a New World monkey. [PDF]
PLoS ONE, 2013 Previous BAC clone analysis of the Platyrrhini owl monkey KIRs have shown an unusual genetic structure in some loci. Therefore, cDNAs encoding KIR molecules from eleven Aotus vociferans monkeys were characterized here; ten putative KIR loci were found ...
Diego Garzón-Ospina +4 more
doaj +1 more source
Mechanisms of Copy Number Variation and Hybrid Gene Formation in the KIR Immune Gene Complex [PDF]
, 2011 The fine-scale structure of the majority of copy number variation (CNV) regions remains unknown. The killer immunoglobulin receptor (KIR) gene complex exhibits significant CNV.
Carrington, Mary +8 more
core +1 more source
Killer Cell Immunoglobulin-Like Receptors (KIR) Typing by DNA Sequencing [PDF]
, 2012 DNA sequencing is a powerful technique for identifying allelic variation within the natural killer cell immunoglobulin-like receptor genes. Because of the relatively large size of the KIR genes, each locus is amplified in two or more overlapping segments.
Lihua, Hou +5 more
openaire +2 more sources
G Protein-Coupled Receptor Signaling to Kir Channels in Xenopus Oocytes [PDF]
Current Pharmaceutical Biotechnology, 2014 Kir3 (or GIRK) channels have been known for nearly three decades to be activated by direct interactions with the βγ subunits of heterotrimeric G (Gαβγ) proteins in a membrane-delimited manner. Gα also interacts with GIRK channels and since PTX-sensitive Gα subunits show higher affinity of interaction they confer signaling specificity to G Protein ...
Candice, Hatcher-Solis +10 more
openaire +2 more sources
Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients
Mediators of Inflammation, 2020 We investigated activation status, cytotoxic potential, and gut homing ability of the peripheral blood Natural Killer (NK) cells in Crohn disease (CD) patients. For this purpose, we compared the expression of different activating and inhibitory receptors
Suzanne Samarani +7 more
doaj +1 more source
HLA and KIR Frequencies in Sicilian Centenarians [PDF]
, 2010 Several studies suggest that human longevity appears to be linked inextricably with optimal functioning of the immune system, suggesting that specific genetic determinants may reside in loci that regulate the immune response, as human leukocyte antigen
CANDORE, Giuseppina +5 more
core +1 more source
KIR receptors and HLA‐C in the maintenance of pregnancy
Tissue Antigens, 2007 AbstractThe present study demonstrated that patients who have recurrent spontaneous abortions (RSA) presented a decreased number of killer immunoglobulin‐like inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was found increased in comparison with controls. Individuals AA will also be homozygous for 2DL3, which in contrast to 2DL2,
Flores, Ana Claudia +6 more
openaire +3 more sources
KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles. [PDF]
, 2016 KIR2DL2 and KIR2DL3 segregate as alleles of a single locus in the centromeric motif of the killer cell immunoglobulin-like receptor (KIR) gene family. Although KIR2DL2/L3 polymorphism is known to be associated with many human diseases and is an important
Bao, Ju +5 more
core +1 more source