G Protein-Coupled Receptor Signaling to Kir Channels in Xenopus Oocytes [PDF]
Current Pharmaceutical Biotechnology, 2014 Kir3 (or GIRK) channels have been known for nearly three decades to be activated by direct interactions with the βγ subunits of heterotrimeric G (Gαβγ) proteins in a membrane-delimited manner. Gα also interacts with GIRK channels and since PTX-sensitive Gα subunits show higher affinity of interaction they confer signaling specificity to G Protein ...
Candice, Hatcher-Solis +10 more
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The Structure, Evolution, and Gene Expression Within the Caprine Leukocyte Receptor Complex
Frontiers in Immunology, 2019 The leukocyte receptor complex (LRC) encodes a large number of immunoglobulin (Ig)-like receptors involved in the immune response, particularly in modulating natural killer (NK) cell function.
John C. Schwartz +5 more
doaj +1 more source
Analysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE
BMC Biology, 2022 Background Natural killer (NK) cells represent a critical component of the innate immune system’s response against cancer and viral infections, among other diseases.
Galen F. Gao +3 more
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Natural Killer Cells Offer Differential Protection From Leukemia in Chinese Southern Han
Frontiers in Immunology, 2019 Interactions of human natural killer (NK) cell inhibitory receptors with polymorphic HLA-A, -B and -C molecules educate NK cells for immune surveillance against tumor cells. The KIR A haplotype encodes a distinctive set of HLA-specific NK cell inhibiting
Zhihui Deng +20 more
doaj +1 more source
Immunorecognition of leukemic stem cells by NK cells : the role of HDAC inhibitors in NKG2D ligand-mediated anti-tumor responses in acute myeloid leukemia [PDF]
, 2008 The diagnosis of acute myeloid leukemia (AML) is associated to a poor long-term outcome due to frequent relapse despite intensive chemotherapy, radiation and hematopoietic stem cell transplantation (HSCT) as well as continuous advances in treatment ...
Langenkamp, Ulrich
core +1 more source
KIR genotype distribution among patients with chronic lymphocytic leukemia: Is there a role for KIR 2DS4 and KIR 2DS5 genes? [PDF]
, 2016 Introduction The function of natural killer (NK) cells is regulated by different antigen receptors including killer immunoglobulin-like receptors (KIR). In addition to their important role in fighting infection, natural killer cells produce cytotoxicity ...
Hoteit, Rouba M. +5 more
core +1 more source
Killer Cell Immunoglobulin-Like Receptors (KIR) Typing by DNA Sequencing [PDF]
, 2012 DNA sequencing is a powerful technique for identifying allelic variation within the natural killer cell immunoglobulin-like receptor genes. Because of the relatively large size of the KIR genes, each locus is amplified in two or more overlapping segments.
Lihua, Hou +5 more
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A novel system of polymorphic and diverse NK cell receptors in primates.
PLoS Genetics, 2009 There are two main classes of natural killer (NK) cell receptors in mammals, the killer cell immunoglobulin-like receptors (KIR) and the structurally unrelated killer cell lectin-like receptors (KLR).
Anne Averdam +18 more
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Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes [PDF]
The Journal of Immunology, 2015 Abstract The human killer cell Ig-like receptor (KIR) locus comprises two groups of KIR haplotypes, termed A and B. These are present in all human populations but with different relative frequencies, suggesting they have different functional properties that underlie their balancing selection.
Hugo G Hilton +6 more
openaire +2 more sources
Frontiers in Immunology, 2018 Killer cell immunoglobulin-like receptors (KIR), considered the most polymorphic natural killer (NK) cell regulators, bind HLA class-I molecules or still unknown ligands.
Laia Closa +7 more
doaj +1 more source