Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source
Polymer-Metal Hybrid Composites: An Overview of the Role of Metal Architecture. [PDF]
Pavlovic A, Santulli C, Fragassa C.
europepmc +1 more source
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang +7 more
wiley +1 more source
AlSi10Mg Heat Sinks for Passive Cooling: Convective-Radiative Performance of Finned and Triply Periodic Minimal Surface Designs via Laser Powder Bed Fusion. [PDF]
Hollaman JT +3 more
europepmc +1 more source
Measurement-Based Optimization of a Lightweight Upper-Extremity Rehabilitation Exoskeleton for Task-Oriented Treatment. [PDF]
Falkowski P +8 more
europepmc +1 more source
A versatile and simple rectangular-topology strategy enables robust hydrogels. [PDF]
Yang Z +5 more
europepmc +1 more source
Topology Reconfiguration for NoCs: A Fast Reconfiguration Algorithm Based on Monotonic Path Shifting. [PDF]
Zhang M, Wang Z, Wang Z, Xu D, Niu N.
europepmc +1 more source
3D-printed metamaterial femoral prostheses via scalar field fusion and directional porous structure regulation. [PDF]
Zhang G +6 more
europepmc +1 more source
Cross-Layer Protocol Design and Performance Evaluation of LoRa Ad Hoc Networks for Heterogeneous Traffic. [PDF]
Pang S +6 more
europepmc +1 more source
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VIRTUAL TOPOLOGY OPERATORS FOR MESHING
International Journal of Computational Geometry & Applications, 2000In recent years several automatic 3D meshing algorithms have emerged. However direct analysis of CAD models is still elusive. Among the major obstacles preventing automation is the necessity to edit the CAD models to be suitable both for the analysis objectives and the available meshing algorithms.
Alla Sheffer +3 more
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