Results 241 to 250 of about 644,615 (299)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

open access: yesAdvanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim   +12 more
wiley   +1 more source

The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs

open access: yesAdvanced Science, EarlyView.
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang   +7 more
wiley   +1 more source

Measurement-Based Optimization of a Lightweight Upper-Extremity Rehabilitation Exoskeleton for Task-Oriented Treatment. [PDF]

open access: yesSensors (Basel)
Falkowski P   +8 more
europepmc   +1 more source
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VIRTUAL TOPOLOGY OPERATORS FOR MESHING

International Journal of Computational Geometry & Applications, 2000
In recent years several automatic 3D meshing algorithms have emerged. However direct analysis of CAD models is still elusive. Among the major obstacles preventing automation is the necessity to edit the CAD models to be suitable both for the analysis objectives and the available meshing algorithms.
Alla Sheffer   +3 more
openaire   +1 more source

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