Results 21 to 30 of about 9,176 (264)

Analytical study on meshing performance of helical cylindrical gears with the coupling of tooth flank morphology and installation error

Journal of Advanced Mechanical Design, Systems, and Manufacturing
This paper investigates the coupling mechanism between installation errors of helical cylindrical gears and tooth flank modification methods on meshing performance.
Chengcheng LIANG, Yihao ZHANG, Longhua LIU, Ruijun LIU   +3 more
doaj   +1 more source

Rome: Performance and Anonymity using Route Meshes [PDF]

IEEE INFOCOM 2009, 2009
Deployed anonymous networks such as Tor focus on delivering messages through end-to-end paths with high anonymity. Selection of routers in the anonymous path construction is either performed randomly, or relies on self-described resource availability at routers, making systems vulnerable to low-resource attacks.
Krishna P. N. Puttaswamy, Alessandra Sala, Ömer Egecioglu, Ben Y. Zhao   +3 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Comprehensive Study on Meshing Performances Compensation for Face-Hobbed Hypoid Gears: Coupled Analysis of Spatial Installation Errors and Manufactured Tooth Flank Characteristics

Machines
In manufacturing face-hobbing hypoid gears, the coupling between tooth flank errors and installation errors has a significant impact on dynamic meshing behavior, yet quantitative models for their synergistic effects remain scarce.
Chengcheng Liang, Yihao Zhang, Longhua Liu, Chaosheng Song, Siyuan Liu   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Performance Evaluation of an Hybrid Mesh and Sensor Network [PDF]

2011 IEEE Global Telecommunications Conference - GLOBECOM 2011, 2011
Wireless Sensor Networks (WSNs) provide an extensible and effective means to monitor large and geographically diverse areas. Nodes in a WSN are characterized by very strict constraints in terms of computing power and energy consumption, as a result of which efficient and secure data aggregation techniques are being proposed as enabling technology for ...
Roberto Riggio, Tinku Rasheed, Sabrina Sicari   +2 more
openaire   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Kinematic Characteristic Analysis of Hypoid Gear based on Two Kinds of Eigenfunction

Jixie chuandong, 2021
Based on the classical space meshing theory， two kinds of basic eigenfunctions and eigenvectors of conjugate surfaces are defined. The function of the two kinds of eigenfunctions in the analysis of the meshing characteristics of conjugate surfaces is ...
Bingyang Wei, Ke Zhang, Bo Zhang, Yuliang Guo   +3 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source