Results 31 to 40 of about 9,176 (264)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Performance Analysis for Mesh and Mesh-Spectral Archetype Applications
, 1998 Submitted - CSTR1998.pdf Submitted - postscript ...
Rifkin, Adam, Massingill, Berna
openaire +2 more sources
Computerized Generation and Surface Deviation Correction of Ruled Surface for Face Gear Drives
Applied SciencesIn order to solve the problems of low efficiency and complex cutting tools in conventional face gear machining, this paper presents a machining method of ruled surface face gears with conical cutters and proposes a new pinion to correct deviation and its
Xianlong Peng, Yikai Wu
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Study on the Coupling Relationship between Wear and Dynamics in Planetary Gear Systems
Machines, 2023 The occurrence of wear is hard to avoid in gear systems because of their transmission principle. Wear will lead to a deviation of the system’s performance from the design objectives or even failure.
Jun Chen, Ning Dong, Jiahua Min
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Meshing performance investigations on oblique worm drive
Journal of Advanced Mechanical Design, Systems, and ManufacturingThis paper proposed an innovative approach to oblique worm drive by introducing a specific inclination angle. The investigation focused on the meshing performance of oblique ZA worm drive by varying the crossed axis angle. The meshing geometric models of
Zhenglin YANG +4 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source