Results 31 to 40 of about 9,015 (265)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Design and Simulation of Meshing Performance of Modified Straight Bevel Gears
Metals, 2020 As key components to transmit power and motion between intersecting shafts, it is necessary to design feasible tooth axial modification to improve the meshing performance and bearing capacity of straight bevel gears.
Mingzhang Chen +2 more
doaj +1 more source
Performance analysis of sparse traffic grooming in WDM mesh networks
IEEE International Conference on Communications, 2005. ICC 2005. 2005, 2005 Sparse traffic grooming is a practical problem to be addressed in heterogeneous multi-vendor optical WDM networks where only some of the optical cross-connects (OXCs) have grooming capabilities. Such a network is called as a sparse grooming network.
Yao, Wang, Li, Mengke, Ramamurthy, Byrav
openaire +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Jixie chuandong, 2014 Based on the study of the meshing behavior of the silent chain,a new arc type silent chain and sprocket are designed,and the main structure type and technical parameters of them are described.The digital 3Dsimulation model of a new arc type silent chain ...
王振宝, 朱国仁, 贺新华
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Journal of Advanced Mechanical Design, Systems, and ManufacturingThe increasingly demanding service conditions for aviation spiral bevel gears necessitate higher machining accuracy of the tooth surfaces. The conventional constant roll ratio, a critical parameter governing the relative motion between the cradle and the
Siyu YANG +5 more
doaj +1 more source
Performance Analysis of Routing Protocols for WLAN Mesh Networks [PDF]
The KIPS Transactions:PartC, 2007 Mesh networks using WLAN technology have been paid attention as a key wireless access technology. However, many technical issues still exist for its successful deployment. One of those issues is the routing problem that addresses the path setup through a WLAN mesh network for the data exchanges between a station and a wired network.
Jae-Sung Park, Yu-Jin Lim, Sang-Hyun Ahn
openaire +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Jixie chuandong, 2022 Meshing clearance is one of the key factors affecting the transmission performance of cycloid-pin planetary drive such as load capacity，frictional power，vibration and noise.
Yutao Li +3 more
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