Results 51 to 60 of about 66,021 (301)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

基于ADAMS的新型圆弧式齿形链啮合仿真分析

open access: yesJixie chuandong, 2014
Based on the study of the meshing behavior of the silent chain,a new arc type silent chain and sprocket are designed,and the main structure type and technical parameters of them are described.The digital 3Dsimulation model of a new arc type silent chain ...
王振宝, 朱国仁, 贺新华
doaj  

Design and Simulation of Meshing Performance of Modified Straight Bevel Gears

open access: yesMetals, 2020
As key components to transmit power and motion between intersecting shafts, it is necessary to design feasible tooth axial modification to improve the meshing performance and bearing capacity of straight bevel gears.
Mingzhang Chen   +2 more
doaj   +1 more source

Performance analysis of sparse traffic grooming in WDM mesh networks

open access: yesIEEE International Conference on Communications, 2005. ICC 2005. 2005, 2005
Sparse traffic grooming is a practical problem to be addressed in heterogeneous multi-vendor optical WDM networks where only some of the optical cross-connects (OXCs) have grooming capabilities. Such a network is called as a sparse grooming network.
Yao, Wang, Li, Mengke, Ramamurthy, Byrav
openaire   +2 more sources

Performance Analysis of Routing Protocols for WLAN Mesh Networks [PDF]

open access: yesThe KIPS Transactions:PartC, 2007
Mesh networks using WLAN technology have been paid attention as a key wireless access technology. However, many technical issues still exist for its successful deployment. One of those issues is the routing problem that addresses the path setup through a WLAN mesh network for the data exchanges between a station and a wired network.
Jae-Sung Park, Yu-Jin Lim, Sang-Hyun Ahn
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Effect of higher-order roll ratio modification coefficient on meshing behavior of aviation spiral bevel gear

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing
The increasingly demanding service conditions for aviation spiral bevel gears necessitate higher machining accuracy of the tooth surfaces. The conventional constant roll ratio, a critical parameter governing the relative motion between the cradle and the
Siyu YANG   +5 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick   +19 more
wiley   +1 more source

Analysis of the Influence of Clearance on the Meshing Force and Friction Power Loss of Cycloid-pin Gear Transmission

open access: yesJixie chuandong, 2022
Meshing clearance is one of the key factors affecting the transmission performance of cycloid-pin planetary drive such as load capacity,frictional power,vibration and noise.
Yutao Li   +3 more
doaj  

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai   +5 more
wiley   +1 more source

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