Results 51 to 60 of about 65,517 (305)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Design and Simulation of Meshing Performance of Modified Straight Bevel Gears

Metals, 2020
As key components to transmit power and motion between intersecting shafts, it is necessary to design feasible tooth axial modification to improve the meshing performance and bearing capacity of straight bevel gears.
Mingzhang Chen, Xiaoshuang Xiong, Wuhao Zhuang   +2 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

A computationally-efficient numerical model to characterize the noise behavior of metal-framed walls [PDF]

, 2015
Architects, designers, and engineers are making great efforts to design acoustically-efficient metal-framed walls, minimizing acoustic bridging. Therefore, efficient simulation models to predict the acoustic insulation complying with ISO 10140 are needed
Arjunan, Arun, English, Martin, Lister, Paul, Stanford, Mark, Wang, Chang   +4 more
core   +2 more sources

Performance Analysis of Mesh-based NoC’s on Routing Algorithms

International Journal of Electrical and Computer Engineering (IJECE), 2018
The advent of System-on-Chip (SoCs), has brought about a need to increase the scale of multi-core chip networks. Bus Based communications have proved to be limited in terms of performance and ease of scalability, the solution to both bus – based and Point-to-Point (P2P) communication systems is to use a communication infrastructure called Network-on ...
Anala M. R, Amit N. Subrahmanya, Allbright D’Souza   +2 more
openaire   +2 more sources

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

基于ADAMS的新型圆弧式齿形链啮合仿真分析

Jixie chuandong, 2014
Based on the study of the meshing behavior of the silent chain,a new arc type silent chain and sprocket are designed,and the main structure type and technical parameters of them are described.The digital 3Dsimulation model of a new arc type silent chain ...
王振宝, 朱国仁, 贺新华
doaj  

Analysis of the Influence of Clearance on the Meshing Force and Friction Power Loss of Cycloid-pin Gear Transmission

Jixie chuandong, 2022
Meshing clearance is one of the key factors affecting the transmission performance of cycloid-pin planetary drive such as load capacity，frictional power，vibration and noise.
Yutao Li, Shoufeng Jin, Hang Jiao, Yize Hou   +3 more
doaj  

Accuracy of Diagnostic Codes and Algorithms Used to Identify Rheumatoid Arthritis and Juvenile Idiopathic Arthritis in Administrative Claims and Electronic Health Records: Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective This systematic review aimed to assess the diagnostic accuracy of algorithms used to identify rheumatoid arthritis and juvenile idiopathic arthritis in electronic health records. Methods We searched Medline, Embase, and Cochrane Central Register for Controlled Trials databases and included studies that validated case definitions against a ...
Constanza Saka‐Herrán, Jessica Bennett, Yara Alkabti, Muhammad Fatir, Barbara Clyne, Caroline McCarthy, Gráinne Tynan, Nikki Dunne, Michelle Flood, Eoghan McCarthy, Frank Moriarty   +10 more
wiley   +1 more source

Calculation of losses in 2-D photonic crystal membrane waveguides using the 3-D FDTD method [PDF]

, 2004
The three-dimensional finite-difference time-domain method is used to obtain loss per unit length in a two-dimensional photonic crystal membrane waveguide by simulating three different length guides. Results are shown for propagation both above and below
Craddock, IJ, Cryan, MJ, Railton, CJ, Rorison, JM, Wong, DCL, Yu, S   +5 more
core   +2 more sources