Results 11 to 20 of about 7,772 (144)
Finding the dark matter: Large language model-based enzyme kinetic data extractor and its validation. [PDF]
Protein SciAbstract Despite the vast number of enzymatic kinetic measurements reported across decades of biochemical literature, the majority of relational enzyme kinetic data—linking amino acid sequence, substrate identity, kinetic parameters, and assay conditions—remains uncollected and inaccessible in structured form.
Wei G, Ran X, Ai-Abssi R, Yang Z.
europepmc +2 more sources
Donor‐Acceptor Activation of Carbon Dioxide
Chemistry – A European Journal, Volume 29, Issue 61, November 2, 2023., 2023 The cooperative activation of carbon dioxide by donor‐acceptor interactions have become a highly popular strategy whose chemical designs span across the whole periodic table. This perspective categorizes the wide variety of systems reported and assesses their limitations and prospects to develop catalytic functionalization protocols.
Marina Pérez‐Jiménez +3 more
wiley +1 more source
Two‐Eyed Seeing as a strategic dichotomy for decolonial nursing knowledge development and practice
Nursing Inquiry, Volume 30, Issue 4, October 2023., 2023 Abstract The profession of nursing has recognized the need for contextual and relational frameworks to inform knowledge development. Two‐Eyed Seeing is a framework developed by Mi'kmaw Elders to respectfully engage with Indigenous and non‐Indigenous knowledges. Some scholars and practitioners, however, are concerned that Two‐Eyed Seeing re‐instantiates
Alysha McFadden +2 more
wiley +1 more source
A Blueprint for the Stabilization of Sub‐Valent Alkaline Earth Complexes**
Chemistry – A European Journal, Volume 29, Issue 54, September 26, 2023., 2023 Group 2 metals are classically found in the +2 oxidation state and their sub‐valent chemistry is hugely underdeveloped. Here we present a blueprint for a new approach towards the synthesis and stabilization of heavy Group 2 metals in the +1 oxidation state, based on the use of highly equatorial ligand environments (i. e. trigonal planar, square planar).
Alex W. J. Bowles +5 more
wiley +1 more source
Global Change Biology, Volume 29, Issue 7, Page 1922-1938, April 2023., 2023 A wide range of experiments have been conducted that manipulate CO2, temperature, and nutrient and water availability in terrestrial ecosystems. Syntheses of results across such experiments provide a general sense of ecosystem responses to global change.
Kevin Van Sundert +18 more
wiley +1 more source
Regioselective 2′‐Silylation of Purine Ribonucleosides for Phosphoramidite RNA Synthesis
Current Protocols, Volume 3, Issue 1, January 2023., 2023 Abstract This article describes high‐yield procedures for protection of purine ribonucleosides based on a reaction that allows highly regioselective 2′‐silylation. Each protocol makes use of two transient protection steps. In the case of tritylation of the 5′ hydroxyl, the 2′,3′‐diol is protected by reaction with N,N‐dimethylformamide dimethylacetal ...
Barbara L. Gaffney, Roger A. Jones
wiley +1 more source
Human Mutation, Volume 2023, Issue 1, 2023., 2023 A large number of variants identified through clinical genetic testing in disease susceptibility genes are of uncertain significance (VUS). Following the recommendations of the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP), the frequency in case‐control datasets (PS4 criterion) can inform their ...
Maria Zanti +126 more
wiley +1 more source
Exploiting commutativity to reduce the cost of updates to shared data in cache-coherent systems [PDF]
, 2015 We present Coup, a technique to lower the cost of updates to shared data in cache-coherent systems. Coup exploits the insight that many update operations, such as additions and bitwise logical operations, are commutative: they produce the same final ...
Horn, Webb H +2 more
core +1 more source
Cache Coherence Protocol Design and Simulation Using IES (Invalid Exclusive read/write Shared) State
مجلة بغداد للعلوم, 2017 To improve the efficiency of a processor in recent multiprocessor systems to deal with data, cache memories are used to access data instead of main memory which reduces the latency of delay time.
Baghdad Science Journal
doaj +1 more source
FASTM: a log-based hardware transactional memory with fast abort recovery [PDF]
, 2009 Version management, one of the key design dimensions of Hardware Transactional Memory (HTM) systems, defines where and how transactional modifications are stored. Current HTM systems use either eager or lazy version management.
González Colás, Antonio María +2 more
core +1 more source