Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source
Ensuring end-to-end privacy in IoT-based healthcare systems through hyperledger fabric and identity mixer. [PDF]
PLoS OneNasr Esfahani M +2 more
europepmc +1 more source
Temporal Interference Stimulation Enhances Neural Regeneration
Advanced Science, EarlyView.Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti +15 more
wiley +1 more source
Enhanced Security of Bidirectional Communication in IoT-Driven Utility Networks Using Sertainty UXP and LoRaWAN. [PDF]
Sensors (Basel)Simin ZA +3 more
europepmc +1 more source
Advanced Science, EarlyView.A reconfigurable physical unclonable function is developed using CMOS‐integrated SOT‐MRAM chips, leveraging a dual‐pulse strategy and offering enhanced environmental robustness. A temperature‐compensation effect arising from the CMOS transistor and SOT‐MTJ is revealed and established as a key prerequisite for thermal resilience.
Min Wang +7 more
wiley +1 more source
Research on Lightweight Dynamic Security Protocol for Intelligent In-Vehicle CAN Bus. [PDF]
Sensors (Basel)Wang Y, Xu Y, Liu Z, Liu S, Wu Y.
europepmc +1 more source
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
DA34FL: a robust dynamic accumulator-based authentication and key agreement with preserving model training data integrity for federated learning. [PDF]
Sci RepLi S, Zhang Y, Bai J, Fan K.
europepmc +1 more source
The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos
Advanced Science, EarlyView.Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan +8 more
wiley +1 more source
The WeDDa framework for preventing smishing and vishing using protocol agnostic cryptographic trust. [PDF]
Sci RepSalem MFM, Hamad EKI, El-Bendary MAM.
europepmc +1 more source