Results 91 to 100 of about 190,885 (290)

PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. [PDF]

, 2015
PPM1D phosphatase, also called wild-type p53-induced phosphatase 1, promotes tumor development by inactivating the p53 tumor suppressor pathway.
Chen, X, Xu, E, Zhang, J, Zhang, M
core   +2 more sources

Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

Advanced Healthcare Materials, EarlyView.
Rolling ultraminiaturized microneedle spheres (RUMS), created via two‐photon polymerization, unlock effective and painless topical delivery of messenger RNA (mRNA) and drugs through the skin. By gently forming thousands of microscopic pores, RUMS boost skin permeability by up to 100‐fold.
Theocharis Nikiforos Iordanidis, Argyris Spyrou, Samantha Roudi, Fredrik J. Swartling, Göran Stemme, Samir EL Andaloussi, Niclas Roxhed   +6 more
wiley   +1 more source

Long-Distance Transport of Prosystemin Messenger RNA in Tomato

Frontiers in Plant Science, 2017
Main conclusion: The transcripts of transgenic prosystemin (PS) gene are mobile and the PS mRNA can be translated into protein in tomato and tobacco plants.
Haiyan Zhang, Yuanyuan Hu, Yuanyuan Hu
doaj   +1 more source

Localisation of RNAs into the germ plasm of vitellogenic xenopus oocytes [PDF]

, 2013
We have studied the localisation of mRNAs in full-grown Xenopus laevis oocytes by injecting fluorescent RNAs, followed by confocal microscopy of the oocyte cortex.
B Heinrich, C Hudson, C Wang, CM Gallo, CP Brangwynne, DR Drummond, F Bontems, F Lai, FF Lai, FL Marlow, Gert Jan C. Veenstra, H MacArthur, H MacArthur, Hugh R. Woodland, HW Song, IM Palacios, J Heasman, J Heasman, JA Gagnon, JB Glotzer, JK Yisraeli, JK Yisraeli, JN Betley, JO Deshler, K Kosaka, K Yaniv, KE Schroeder, KM Forrest, L Allen, L Dale, L Mosquera, M Claussen, M Claussen, M Kloc, M Kloc, M Kloc, M Kloc, M Kloc, M Kloc, M Ku, ME Kloc, ME Pepling, ML King, NR Zearfoss, O Hachet, P Chang, PM Macdonald, PT Richardson, QH Tao, RA Lewis, RJ Machado, RS Hames, RT Cox, S Choo, S Guedes, S Kwon, Sarbjit Nijjar, SN Hird, TJ Messitt, U Wolke, VB Alarcon, VL Zimyanin, WV Gerber, Y Zhang, Y Zhou, Y Zhou, Y Zhou   +66 more
core   +2 more sources

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Modeling noise in gene expression

Ontare, 2015
 ONTARE. REVISTA DE INVESTIGACIÓN DE LA FACULTAD DE INGENIERÍA This study deals with the modeling of the basic steps of gene expression in biological systems.
Ivan Mura
doaj  

Origin of symbol-using systems: speech, but not sign, without the semantic urge [PDF]

, 2014
Natural language—spoken and signed—is a multichannel phenomenon, involving facial and body expression, and voice and visual intonation that is often used in the service of a social urge to communicate meaning.
Alberts B, Baldwin JM, Darwin C, Darwin C, Deacon TW, Donald M, Fauconnier G, Gross CG, Hauser M, Jablonski NG, Jackendoff R, Judson HF, Kendon A, King BJ, Klima ES, Knight C, Langacker R, Martin I. Sereno, Merker B, Miller SL, Mithen S, Rubens AB, Sereno MI, Sereno MI, Sereno ML, Wills C, Woese CR, Yip M   +27 more
core   +2 more sources

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

Advanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane   +9 more
wiley   +1 more source

Intracellular Chloride Concentration Changes Modulate IL-1β Expression and Secretion in Human Bronchial Epithelial Cultured Cells [PDF]

, 2017
Cystic fibrosis (CF) is caused by mutations in the CFTR gene, which encodes a cAMP‐regulated chloride channel. Several cellular functions are altered in CF cells. However, it is not clear how the CFTR failure induces those alterations.
Clauzure, Mariangeles, Dugour, Andrea Vanesa, Figueroa, Juan Manuel, Massip Copiz, María Macarena, Mori, Consuelo, Santa Coloma, Tomás Antonio, Valdivieso, Ángel Gabriel   +6 more
core   +1 more source

The intracellular localization of messenger RNAs

Cell, 1995
As I hope this review has made clear, mRNA localization plays an important role in directing specific proteins to their correct position within a cell. Although the study of this process is still in its infancy, it is already apparent that there are several ways that mRNAs can be targeted to particular subcellular sites.
openaire   +3 more sources