Results 141 to 150 of about 190,885 (290)
Advanced Science, EarlyView.NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu +15 more
wiley +1 more source
Boolean Models of Bistable Biological Systems
, 2009 This paper presents an algorithm for approximating certain types of dynamical systems given by a system of ordinary delay differential equations by a Boolean network model.
A. Novick +16 more
core +1 more source
STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches
Advanced Science, EarlyView.This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan +10 more
wiley +1 more source
Advanced Science, EarlyView.CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu +14 more
wiley +1 more source
Isolation of Polyribosomes and Messenger RNA Active in in Vitro Synthesis of Soybean Seed Proteins [PDF]
, 1978 Roger N. Beachy +2 more
openalex +1 more source
Advanced Science, EarlyView.Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo +9 more
wiley +1 more source
Engineering Liquid Hierarchical Materials with DNA‐Programmed Spherical Nucleic Acids
Advanced Science, EarlyView.Programmable spherical nucleic acids assembly strategies for constructing hierarchical structures through engineered DNA bond to form novel liquid‐like metal droplets. Abstract Inspired by nature, the orchestration of self‐assembling building blocks into hierarchical superstructures offers a transformative approach to functional materials design. While
Zeyu Chen +7 more
wiley +1 more source
The nature of messenger RNA in the early stages of sea urchin development.
, 1966 Vladimir Glišin +2 more
openalex +1 more source
Advanced Science, EarlyView.Orthodontic relapse persists as a 120‐year challenge, as traditional retainers fail to remodel tissue, causing lifelong dependence. This study demonstrates a flexible magnetoelectric retainer (FMOR) enabling wireless periodontal remodeling. FMOR cues shift periodontal ligament cell (PDLC) paracrine signaling, promoting M2 macrophages, osteogenic ...
Haoqi Lei +9 more
wiley +1 more source