Supplementary Notes from Genomic Profiling of MicroRNA and Messenger RNA Reveals Deregulated MicroRNA Expression in Prostate Cancer [PDF]
, 2023 Stefan Ambs +12 more
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Encapsulation state of messenger RNA inside lipid nanoparticles
Biophysical Journal, 2021 M. Brader +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen +16 more
wiley +1 more source
Genome-wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules [PDF]
, 2007 Michael D. Blower +3 more
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Advanced Science, EarlyView.PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia +14 more
wiley +1 more source
Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function. [PDF]
, 1993 Patrick M. Sullivan, Y M Wang, D. Joseph
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Advanced Science, EarlyView.Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao +14 more
wiley +1 more source
Quantification of thyroglobulin messenger RNA byIn situ hybridization in. Differentiated thyroid cancers difference between well-differentiated and moderately differentiated histologic types [PDF]
, 1985 Jean‐Louis Bergé‐Lefranc +4 more
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Early vs Deferred Non–Messenger RNA COVID-19 Vaccination Among Chinese Patients With a History of Inactive Uveitis [PDF]
, 2023 Zhenyu Zhong +9 more
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Advanced Science, EarlyView.This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan +16 more
wiley +1 more source