Results 221 to 230 of about 1,613,624 (375)

Three decades of messenger RNA vaccine development

open access: yesNano Today, 2019
Rein Verbeke   +3 more
semanticscholar   +1 more source

Development of an efficient mice model of cancer‐associated cardiac cachexia

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong   +9 more
wiley   +1 more source

Physicochemical and functional assessment of messenger RNA 5'Cap-end impurities under forced degradation conditions. [PDF]

open access: yesMol Ther Nucleic Acids
Hutchinson J   +14 more
europepmc   +1 more source

Lipid nanoparticles for delivery of messenger RNA to the back of the eye.

open access: yesJournal of Controlled Release, 2019
Siddharth Patel   +4 more
semanticscholar   +1 more source

Establishment and molecular profiling of a PDX model of a metachronous brain tumor in a patient with constitutional mismatch repair deficiency with biallelic MSH6 variant

open access: yesAnimal Models and Experimental Medicine, EarlyView.
A 6½‐year‐old girl was diagnosed with a medulloblastoma, SHH activated, subtype 3 and TP53 mutant (somatic). After surgery and chemotherapy, she was monitored with quarterly magnetic resonance imaging (MRI) scans and remained free of disease for almost 4 years.
Daniel Antunes Moreno   +19 more
wiley   +1 more source

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