Results 241 to 250 of about 1,626,022 (379)

EnsembleDesign: messenger RNA design minimizing ensemble free energy via probabilistic lattice parsing. [PDF]

Bioinformatics
Dai N, Zhou T, Tang WY, Mathews DH, Huang L.   +4 more
europepmc   +1 more source

Plasminogen activator inhibitor-1 messenger RNA expression is induced in rat hepatocytes in vivo by dexamethasone [PDF]

, 1992
BA Konkle, S. J. Schuster, MD Kelly, K Harjes, DE Hassett, M Bohrer, Mehdi Tavassoli   +6 more
openalex   +1 more source

Messenger RNA modifications: Form, distribution, and function

Science, 2016
Wendy V. Gilbert, Tristan A. Bell, Cassandra Schaening   +2 more
semanticscholar   +1 more source

Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide‐induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2

Animal Models and Experimental Medicine, EarlyView.
The interaction between mitofusin 2 (MFN2) and phosphofurin acidic cluster sorting protein 2 regulates the formation of mitochondria‐associated endoplasmic reticulum membranes (MAM). Overexpression of MFN2 can promote the formation of MAMs and inhibit inflammation and oxidative stress response in mammary epithelial cells.
Xiechen Zhou, Yufei Zhang, He Ma, Shoupeng Fu, Juxiong Liu, Wenjin Guo, Xiaofeng Tian, Bingxu Huang   +7 more
wiley   +1 more source

Nanoparticle‐Based Tolerogenic Vaccines: Next‐Generation Strategies for Autoimmune and Allergic Disease Therapies

Angewandte Chemie, EarlyView.
Nanoparticle‐based tolerogenic vaccines harness controlled antigen delivery and immunomodulation to establish tolerance in autoimmunity and allergy. This review outlines how nanoparticle design (size, shape, composition, administration route) influences biodistribution and immune‐cell targeting.
Benjamin E. Nachod, Ajay S. Thatte, Rohan Palanki, Michael J. Mitchell   +3 more
wiley   +2 more sources

Physicochemical and functional assessment of messenger RNA 5'Cap-end impurities under forced degradation conditions. [PDF]

Mol Ther Nucleic Acids
Hutchinson J, Schweikart F, Shannon R, Murthy A, Bates SM, Leone S, Nissan T, Sideris D, Lal C, Button J, Rani R, Thom G, Bond N, Örnskov E, Trabulo S.   +14 more
europepmc   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Effects of Modified Messenger RNA of Adiponectin Delivered by Lipid Nanoparticles on Adipogenesis and Bone Metabolism In Vitro and In Vivo. [PDF]

Cells
Xie Y, Ma Q, Wang J, Zhu ZX, El-Araby RE, Tu M, Li Z, Xu X, Tu Q, Chen J.   +9 more
europepmc   +1 more source

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

Cell Reports, 2017
D. An, Jessica L. Schneller, A. Frassetto, Shi Liang, Xuling Zhu, Ji-Sun park, M. Theisen, Sue‐Jean Hong, Jenny Zhou, Rajini Rajendran, B. Levy, R. Howell, Gilles Besin, Vladimir Presnyak, S. Sabnis, Kerry E. Murphy-Benenato, E. Kumarasinghe, Timothy Salerno, C. Mihai, Christine M. Lukacs, R. Chandler, L. Guey, C. Venditti, P. Martini   +23 more
semanticscholar   +1 more source

Engineering Ultrasound Contrast Agents for Targeted Therapeutics: A Theranostic Approach to Drug Delivery, Gene Therapy, and Immunomodulation

Advanced NanoBiomed Research, EarlyView.
Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza, Kimia Mozahheb Yousefi, Sara Minaeian   +2 more
wiley   +1 more source