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Messenger RNA movement on the ribosome

Molecular Biology, 2007
Recent X-ray and cryo-EM studies of 70S ribosome complexes containing different types of messenger RNAs (mRNA) and transfer RNA (tRNA) have been reviewed. Changes of the mRNA path on the ribosome at initiation and elongation states have been described.
Yusupova, G., Jenner, L., Yusupov, M.
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Messenger RNA Decay

EcoSal Plus, 2007
This chapter discusses several topics relating to the mechanisms of mRNA decay. These topics include the following: important physical properties of mRNA molecules that can alter their stability; methods for determining mRNA half-lives; the genetics and biochemistry of proteins and enzymes involved in mRNA decay; posttranscriptional ...
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Evidence that immune RNA is messenger RNA

Cellular Immunology, 1976
Abstract Exposure of rabbit spleen cell cultures to i-RNA isolated from T2 phage-exposed rabbit peritoneal exudate cells induces the synthesis of antigen and allotype specific 19S proteins even in the presence of actinomycin D. The same i-RNA directs the synthesis of proteins with comparable properties in cell-free extracts prepared from mouse L ...
Patricia Bilello   +3 more
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Immunoglobulin messenger RNAS of T lymphocytes

Molecular Immunology, 1980
The potential of T cells to synthesize immunoglobulins was investigated in thymus cells obtained from young mice. Such thymocytes contained very low levels of B cell contamination. It was found by hybridization of thymus RNA with complementary DNAs (cDNAs) synthesized from myeloma κ and H chain mRNAs that these T cells contain relatively large amounts ...
Storb, U, Near, R, Putnam, D, Clagett, J
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Methylation of messenger RNA

Trends in Biochemical Sciences, 1976
Abstract Eukaryotic messenger RNA molecules contain methylated nucleotides, both at their 5′-terminal end in a unique ‘cap' structure, and internally as 6-methyladenylic acid. Similar methylation patterns are.found in heterogeneous nuclear RNA molecules.
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Vaccination With Messenger RNA

2006
As an alternative to DNA-based vaccines, messenger RNA (mRNA)-based vaccines present additional safety features: no persistence, no integration in the genome, no induction of autoantibodies. Moreover, mRNA which are generated by in vitro transcription, are easy to produce in large amounts and very high purity.
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Chapter 25 RNA Decay by Messenger RNA Interferases

2008
Two abundant toxin-antitoxin (TA) gene families, relBE and mazEF, encode mRNA cleaving enzymes whose ectopic overexpression abruptly inhibits translation and thereby induces a bacteriostatic condition. Here we describe and discuss protocols for the overproduction, purification, and analysis of mRNA cleaving enzymes such as RelE of Escherichia coli and ...
Christensen-Dalsgaard, Mikkel   +3 more
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