Results 311 to 320 of about 1,593,615 (383)

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Capillary‐Based Physicochemical Characterization of Lipid Nanoparticles

ELECTROPHORESIS, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) are widely used for the delivery of nucleic acid (NAs), most notably in gene therapy and messenger ribonucleic acid (mRNA)‐based vaccines. Understanding their physicochemical properties is essential, yet current analytical approaches often fall short in capturing their complexity.
Evrim Ümit Kuzucu, Valentin Schittny, Jörg Huwyler, Maria Anna Schwarz   +3 more
wiley   +1 more source

Safety and Immunogenicity of a Messenger RNA-Based Cytomegalovirus Vaccine in Healthy Adults: Results From a Phase 1 Randomized Clinical Trial. [PDF]

J Infect Dis
Fierro C, Brune D, Shaw M, Schwartz H, Knightly C, Lin J, Carfi A, Natenshon A, Kalidindi S, Reuter C, Miller J, Panther L.   +11 more
europepmc   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Optimized strategies for precise messenger RNA delivery using site-specific lipid nanoparticle-based drug delivery systems. [PDF]

Nanomedicine (Lond)
Cao W, Xia T.
europepmc   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Exponential decline, ceiling effect, downregulation, and T-cell response in immunoglobulin G antibody levels after messenger RNA vaccine boosters: a case report. [PDF]

J Med Case Rep
Hirano H, Asada H.
europepmc   +1 more source

Evaluation of Vaginal Probiotic Properties of Food‐Derived Lactic Acid Bacteria: The Inhibition of Gardnerella vaginalis and the Adhesion Capability

Food Bioengineering, EarlyView.
LAB strains isolated from fermented foods possess desirable probiotic properties for vaginal health, offering a valuable alternative to traditional vaginal isolates. ABSTRACT This study aimed to evaluate the vaginal probiotic properties of certain lactic acid bacteria (LAB) strains isolated from fermented foods.
Anqi Li, Minli Ge, Lingzi He, Wenfeng Zhao, Lei Du, Li Zhao, Jingli Xie   +6 more
wiley   +1 more source

Optimizing Messenger RNA Analysis Using Ultra-Wide Pore Size Exclusion Chromatography Columns. [PDF]

Int J Mol Sci
D'Atri V, Lardeux H, Goyon A, Imiołek M, Fekete S, Lauber M, Zhang K, Guillarme D.   +7 more
europepmc   +1 more source