Results 81 to 90 of about 257,181 (321)
Tumor Biology, 2017 Promoter methylation reflects in the inactivation of different genes like O 6 -methylguanine-DNA methyltransferase DNA repair gene and runt-related transcription factor 3, a known tumor suppressor gene in various cancers such as esophageal cancer.
Snigdha Saikia +9 more
doaj +1 more source
Probing Noise in Gene Expression and Protein Production [PDF]
, 2009 We derive exact solutions of simplified models for the temporal evolution of the protein concentration within a cell population arbitrarily far from the stationary state. We show that monitoring the dynamics can assist in modeling and understanding the nature of the noise and its role in gene expression and protein production.
arxiv +1 more source
DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications
Advanced Materials, EarlyView.DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding +5 more
wiley +1 more source
Modeling noise in gene expression
Ontare, 2015 ONTARE. REVISTA DE INVESTIGACIÓN DE LA FACULTAD DE INGENIERÍA This study deals with the modeling of the basic steps of gene expression in biological systems.
Ivan Mura
doaj
Hydroxyapatite Binding Peptide Lipid Nanoparticles for Biomimetic mRNA Delivery to Bone
Advanced Therapeutics, EarlyView.Targeted delivery of therapeutic mRNA to peripheral tissues, including bone, is currently challenging. In the current work, a hydroxyapatite binding peptide (HABP) is conjugated to mRNA lipid nanoparticles (LNPs). HABP‐LNPs delivered systemically are demonstrated to reduce transfection in the liver and improve transfection in the femurs of mice ...
Joshua A. Choe +6 more
wiley +1 more source
Long-Distance Transport of Prosystemin Messenger RNA in Tomato
Frontiers in Plant Science, 2017 Main conclusion: The transcripts of transgenic prosystemin (PS) gene are mobile and the PS mRNA can be translated into protein in tomato and tobacco plants.
Haiyan Zhang, Yuanyuan Hu, Yuanyuan Hu
doaj +1 more source
Kinetic Model of Translational Autoregulation [PDF]
, 2018 We investigate dynamics of a kinetic model of inhibitory autoregulation as exemplified when a protein inhibits its own production by interfering with its messenger RNA, known in molecular biology as translational autoregulation. We first show how linear models without feedback set the stage with a nonequilibrium steady state that constitutes the target
arxiv +1 more source
The intracellular localization of messenger RNAs
Cell, 1995 As I hope this review has made clear, mRNA localization plays an important role in directing specific proteins to their correct position within a cell. Although the study of this process is still in its infancy, it is already apparent that there are several ways that mRNAs can be targeted to particular subcellular sites.
openaire +3 more sources
Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
Romanian Journal of Laboratory Medicine, 2015 Objective: the pourpose of the study was to determine if there are any differences between placenta derived plasmatic levels of messenger RNA in normal and future preeclamptic pregnancies and if these placental transcripts can predict preeclampsia long ...
Surugiu Sebastian +4 more
doaj +1 more source