Results 31 to 40 of about 112,852 (239)

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez   +295 more
wiley   +1 more source

Impact of parameter settings on the estimation of drug exposure with the individualized dispensing patterns method

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim To assess the impact of parameter settings when using the individualized dispensing patterns (IDP) method to estimate exposure duration from dispensing data. Methods We conducted a cohort study using a 2% representative sample of the French healthcare insurance database from 2013 to 2022.
Laëtitia Gosselin   +8 more
wiley   +1 more source

From Material Tensions to Organizational Paradoxes: How Manufacturers Cope With the Limits of Circular Product Design

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT Circular product design (CPD) is central to advancing the circular economy by enabling the narrowing, slowing, and closing of resource flows. Yet, its implementation remains persistently challenging for firms. Prior research has largely framed these challenges as discrete barriers, overlooking the structural contradictions embedded in CPD ...
Vanessa Robertson   +2 more
wiley   +1 more source

Viability analysis and the importance of fine‐scale variables influencing roadkills of a toad population

open access: yesThe Journal of Wildlife Management, EarlyView.
Fine‐scale population variables better explain roadkill patterns in natterjack toads (Epidalea calamita) than habitat proxies, with mortality driven mainly by local abundance, reduced by roadside embankments, and decreasing as the season advanced. Despite high roadkills, population viability analyses indicate no immediate extinction risk under current ...
A. Iglesias‐Donoso   +4 more
wiley   +1 more source

Mestre morto, mestre posto: um outro tamponamento da orfandade [PDF]

open access: yesRevista Latinoamericana de Psicopatologia Fundamental
Retomando as colocações de Jacques Lacan acerca do movimento de maio de 1968 na França, consideramos seus impasses interpretativos enquanto marcas entre o político e o campo psicanalítico.
Ivan Ramos Estevão   +2 more
doaj   +1 more source

Clinical Progression in Alpha‐Synuclein Positive LRRK2‐PD and Sporadic Parkinson's Disease: A Longitudinal Analysis

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background LRRK2‐Parkinson's disease (LRRK2‐PD) is biologically heterogeneous with approximately 30% lacking aggregated alpha synuclein (αSyn) in cerebrospinal fluid by seed amplification assay (SAA). Prior work has suggested slower progression in LRRK2‐PD compared to sporadic PD (sPD).
Lucy A. Morse   +224 more
wiley   +1 more source

Sex Differences in Fall Frequency, Risk Factors, and Outcomes in Parkinson's Disease: A Cross‐Sectional Analysis

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Female sex is an independent fall risk factor in Parkinson's disease (PD), yet sex‐specific fall patterns remain unclear. Objectives To compare sex‐specific fall risk and outcomes across PD, prodromal alpha‐synucleinopathy (PAS), and healthy controls (HC); estimate fall frequency across PD progression; and assess how sex modifies ...
Joaquin A. Vizcarra   +197 more
wiley   +1 more source

Foto-Retrato, Foto-Pintura: Identidades do Cariri

open access: yesVista
Este é um ensaio visual analógico em filme 120mm de retratos de mestres da cultura popular no Cariri. Para ele, foram registrados: o Mestre Chico Alagoano (de fotografia lambe-lambe); o Mestre Nena, bacamarteiro; o Mestre Antônio Matheus do Reisado dos ...
Tiago Pedro Pereira
doaj   +1 more source

Nietzsche educador e a afirmação da singularidade

open access: yesRevista Ibero-Americana de Estudos em Educação, 2022
O artigo tem por objetivo explicitar o impacto de Schopenhauer sobre Nietzsche como um estilo de mestre, incorporando a singularidade como aquilo que a educação promove.
Lúcia Schneider Hardt
doaj   +1 more source

Entrevista com Mestre Camisa [PDF]

open access: yes, 2022
Entrevista com Mestre Camisa.
Röhrig Assunção, Matthias   +4 more
core   +1 more source

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