Results 211 to 220 of about 433,729 (235)

The Evolution of Oligometastatic Pancreatic Ductal Adenocarcinoma: From Anatomic Description to Biologically Informed Patient Selection. [PDF]

Cancers (Basel)
Gaur KS, Hall WA, Kamgar M, McFall T, Evans DB, Seo YD.   +5 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Prognostic Modeling Integrating RAS and SMAD4 Status in Patients with BRAF Wild-Type, Microsatellite-Stable Metastatic Colorectal Cancer. [PDF]

Cancer Res Commun
Nasca V, Tinè G, Walch H, Maddalena G, Germani MM, Ghelardi F, Perissinotto E, Boccaccio C, Manca P, Fassan M, Landi M, Damonte C, Gusmaroli E, Garavaglia A, Bergamo F, Cremolini C, Lonardi S, Miceli R, Pietrantonio F, Randon G.   +19 more
europepmc   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Clinical outcomes and safety of zoledronic acid in castration-resistant metastatic prostate cancer with bone metastases: real-world data from Côte d'Ivoire. [PDF]

Front Oncol
Odo BA, Kouassi KKY, Toure PGL, Gnabro GAP, Touré YL, Madiou MKA, Mbarga Amougou F, Mebiala NMP, Sessegnon FA, Nogbou AMBY, Agrigna H, Sako K, Toure M, Adoubi I.   +13 more
europepmc   +1 more source

Space Jam‐Ming: Generating Interstitial Space Using Fragmented Granular GelMA to Investigate Novel Paradigms of Cancer Metastasis

Advanced Science, EarlyView.
Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala, Zhuang Min Lee, Sebastian E. Amos, Dong Woo Son, Jong Hwa Byun, Farzan Navaeipour, Jiayue Li, Kai L. Metzner, Ji Hoon Jeong, Juyeon Kim, Yongsung Hwang, Brendan F. Kennedy, Khoon S. Lim, Hee Seung Lee, Hyun Woo Park, Yu Suk Choi   +15 more
wiley   +1 more source

Resection of Liver Metastasis from Lacrimal Gland Adenoid Cystic Carcinoma: A Case Report and Review of the Literature. [PDF]

Surg Case Rep
Sugio T, Takada S, Tokuraku S, Ogawa J, Nishida N, Horio H, Takei R, Kato K, Okazaki M, Iwao Y, Nakanuma S, Makino I, Takahira M, Ikeda H, Yagi S.   +14 more
europepmc   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Transcriptional cyclin-dependent kinases as therapeutic targets in bone metastasizing cancers. [PDF]

Front Oncol
Kähkönen TE, Galabova G, Thormann M, Halleen JM.   +3 more
europepmc   +1 more source