Results 231 to 240 of about 878,108 (245)

EpCAM+ Extracellular Vesicle PD‐L1 Dynamics as a Predictive Biomarker of Immune Checkpoint Blockade Response

Advanced Science, EarlyView.
A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun, Jinyoung Kim, Chang Gon Kim, Seokhyeong Go, Mina Han, Yujin Ouck, Soojin Jang, Seong Uk Son, Gamin Kim, Wonrak Son, Eunjung Kim, Min Hee Hong, Ja Hyun Yeo, Eun‐Kyung Lim, Hye Ryun Kim, Seungjoo Haam   +15 more
wiley   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Systemic surveillance for uveal melanoma: Approach to optimization. [PDF]

PLoS One
Zabor EC, Yeşiltaş YS, Singh AD.
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Clinicopathological features and prognoses of HER-2-positive gastric cancer. [PDF]

Mol Clin Oncol
Shen H, Xue X, He H, Lin S.
europepmc   +1 more source

Combined multi-omics profiling and machine learning analysis reveals that Bregs and RPS2 promote bone metastasis in nasopharyngeal carcinoma. [PDF]

Transl Cancer Res
Yang K, Zhang J, Mao X, Chen X, Huang J, Xie K, Lin X, Zhou X, Yu B, Zhao L, Lin Y.   +10 more
europepmc   +1 more source

Penile Metastasis From Castration-Resistant Prostate Cancer: A Case Report. [PDF]

IJU Case Rep
Asakura S, Nakagami Y, Inoue T, Matsui Y, Oshinomi K, Nagata M, Fukagai T, Ohira Y, Yamochi Y.   +8 more
europepmc   +1 more source

Case Report: Targeting EGFR exon 20 insertion and MTAP loss in refractory metastatic upper tract urothelial carcinoma. [PDF]

Front Oncol
Li KHL, Leung RCY, Yau T, Li JJX, Tsang JWY, Lo JWY, Kwok GGW, Wong JSL, Chan AHW, Li BCW.   +9 more
europepmc   +1 more source

Correction to "Rib-Origin Ewing Sarcoma With Cranial Nerve Involvement From Orbital Metastasis: A Rare Case Report". [PDF]

Clin Case Rep
europepmc   +1 more source