Results 11 to 20 of about 17,978 (256)

Patient‐Reported Outcomes with Selpercatinib Treatment Among Patients with RET‐Mutant Medullary Thyroid Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth, Bruce Robinson, Valentina Boni, Daniel S.W. Tan, Caroline McCoach, Erminia Massarelli, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Vivek Subbiah   +10 more
wiley   +1 more source

Pancreatic Adenocarcinoma: Diagnosis by Ultrasound-Guided Fine-Needle Aspiration-Cyto-Histological Correlation and Experience at a Multidisciplinary Tertiary Reference Center. [PDF]

Diagn Cytopathol
ABSTRACT Background Pancreatic adenocarcinoma (PDAC) is characterized by its poor prognosis. Cytology is essential for diagnostic confirmation and ancillary studies. The endoscopic ultrasound (EUS) set a precedent, facilitating cytological sampling through fine‐needle aspiration (FNA), with a sensitivity of 93% and a specificity of 95%.
González-López J, Bauza ME, Pérez-Rojas J, López-Valdivia C, Romero CZ, Castells-Perona Ó, Ballester-Ibáñez C, Montalvá-Orón E, López-Andújar R, Argüello-Viudez L, Rodríguez MP.   +10 more
europepmc   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Tumores testiculares caninos : a propósito de dos casos clínicos [PDF]

, 2010
Los tumores testiculares tienen una mayor incidencia en la especie canina que en otras especies y son una patología habitual en la clínica diaria, aunque generalmente son hallazgos de la exploración física.
Cloquell, A., Díaz, A., Martí, S., Vázquez, F.   +3 more
core   +1 more source

Metástasis gingival de adenocarcinoma de colon [PDF]

, 2006
La cavidad oral es lugar de asiento de tumores metastásicos, sobre todo con origen en mama y pulmón. La mayoría de los casos afectan por este orden a los huesos mandibular y maxilar, aunque en ocasiones se desarrollan sobre las partes blandas intraorales.
Delgado Sánchez-Gracián, Carlos, Iglesias Rodríguez, B., Pazo Irazu, Susana, Álvarez Álvarez, Carlos   +3 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Melanoma metastásico a vejiga

MedUNAB, 2021
RESUMEN Introducción. El compromiso tumoral metastásico del melanoma al tracto genitourinario es frecuente, pero, la metástasis a vejiga es rara, constituye menos del 2% de los casos.
Ana María Ortiz-Zableh, Juan Manuel Sandoval-Ojeda, Natalia Patiño-Covelli, Isabel Cristina Bolívar-Aguilera, Alfredo Ortiz-Azuero   +4 more
doaj   +1 more source

Características clínico-patológicas del adenocarcinoma gástrico en el servicio de patología en el Hospital Escuela Dr. Roberto Calderón Gutiérrez del Enero 2012 hasta Diciembre 2014 [PDF]

, 2015
Con el fin de establecer la correlación clínica - histopatológica de los adenocarcinomas gástricos diagnosticados en el Hospital Escuela Dr. Roberto Calderón Gutiérrez, se realizó un estudio en el periodo comprendido desde enero 2012 a diciembre 2014, se
Ruíz Almanza, Daniel
core  

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

Colorectal cancer carcinogenesis [PDF]

, 2012
El cáncer colorrectal representó en el año 2008 el tercer tumor más diagnosticado en España, siendo la segunda neoplasia que causó más fallecimientos. El conocimiento del proceso carcinogenético de este tipo de enfermedad permitirá el descubrimiento de
Menéndez Sánchez, Pablo, Menéndez, J. M:, Padilla, D., Rodríguez Montes, José Antonio, Villarejo, P.   +4 more
core   +1 more source