Results 51 to 60 of about 23,921,474 (239)

rgs212/Meta-analysis-Smith: Methylation Meta analysis Smith et al

, 2021
Release of "A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex" by Smith and Pishva et al ...
Gemma Shireby, Gilles Gasparoni, Ehsan Pishva, Rebecca G. Smith, Gregory Wheildon, Vahram Haroutunian, Daniel L.A. van den Hove, Andrew J. Sharp, Janou A.Y. Roubroeks, Armin Giese, Wolfgang Viechtbauer, Katie Lunnon, Adam R. Smith, Paul D. Coleman, Eilis Hannon, Diego Mastroeni, Jonathan Mill, Michael Weedon, Jörn Walter, David A. Bennett, Leonard Schalkwyk, Matthias Riemenschneider, Philip L. De Jager   +22 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Informe de práctica empresarial, Alcaldía de Restrepo

, 2023
Informe de práctica profesional del programa de Comunicación Social y PeriodismoLa Alcaldía de Restrepo se crea cuando por medio del Decreto 904 del 23 de septiembre de 1912 cuando el caserío La Concepción fue elevado a la categoría de municipio ...
Sandoval Cisneros, Laura Camila
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Gobernación del Meta

, 2023
Se desarrollan las actividades formativas realizadas en la Dirección departamental para la gestión del riesgo de desastres de la Gobernación del Meta durante el periodo 2023-1, donde se aplicaron los conocimientos obtenidos en el proceso formativo de la ...
Castillo Borbón, Marialicia
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Informe de prácticas empresariales FENALCO seccional Meta y Llanos Orientales

, 2021
La seccional de Fenalco Meta cuenta con cinco áreas de trabajo, el área administrativa, el área de formación especializada, el área de coordinación de afiliados, el área de coordinación de eventos y, por último, el área comercial donde se encuentra el ...
Zamora Palomo, Andry Gimena
core  

Meta-analysis

, 2021
The sheer volume of available research and shifts toward evidence-based practice has led researchers and practitioners in sport and exercise psychology to rely increasingly on meta-analyses to summarize current knowledge, provide future research ...
Hagger, Martin
core   +1 more source