Results 61 to 70 of about 1,483,696 (298)

Cytoreductive surgery (CRS) with hyperthermic intraoperative peritoneal chemotherapy (HIPEC) versus standard of care (SoC) in people with peritoneal metastases from colorectal, ovarian or gastric origin: protocol for a systematic review and individual participant data (IPD) meta-analyses of effectiveness and cost-effectiveness

BMJ Open, 2020
Introduction There is uncertainty about whether cytoreductive surgery (CRS)+hyperthermic intraoperative peritoneal chemotherapy (HIPEC) improves survival and/or quality of life compared with standard of care (SoC) in people with peritoneal metastases who
Brian R Davidson, Tim Mould, Kurinchi Gurusamy, Muntzer Mughal, Claire L Vale, R Bhanot, Mark Saunders, Omer Aziz, Sarah O'Dwyer   +8 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Propensity Score-Based Approaches to Confounding by Indication in Individual Patient Data Meta-Analysis: Non-Standardized Treatment for Multidrug Resistant Tuberculosis. [PDF]

PLoS ONE, 2016
BACKGROUND:In the absence of randomized clinical trials, meta-analysis of individual patient data (IPD) from observational studies may provide the most accurate effect estimates for an intervention. However, confounding by indication remains an important
Gregory J Fox, Andrea Benedetti, Carole D Mitnick, Madhukar Pai, Dick Menzies, Collaborative Group for Meta-Analysis of Individual Patient Data in MDR-TB   +5 more
doaj   +1 more source

Clinical Outcomes of Remote Ischemic Preconditioning Prior to Cardiac Surgery: A Meta‐Analysis of Randomized Controlled Trials [PDF]

Journal of the American Heart Association, 2017
Background Multiple randomized controlled trials of remote ischemic preconditioning ( RIPC ) prior to cardiac surgery have failed to demonstrate clinical benefit. The aim of this updated meta‐analysis was to evaluate the effect of RIPC on outcomes following ...
Pierce, Brian, Bole, Indra, Patel, Vaiibhav, Brown, David L   +3 more
openaire   +5 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Biologics and oral systemic treatment preferences in patients and physicians for moderate-to-severe atopic dermatitis: a discrete choice experiment in the United Kingdom and Germany

Journal of Dermatological Treatment
Background: As the available treatments for moderate-to-severe atopic dermatitis (AD) expand, understanding patient and physician preferences becomes crucial for informed decision-making.Objective: To quantify patient and physician preferences for ...
Nicholas Durno, Pablo Arija, Krystallia Pantiri, Marieke Heisen, Marco Boeri, Josef Paris, Katrin Jack, Olivier Chambenoit, Ramkumar Subramanian, Jorge Puelles, Elly Stolk, Ben van Hout, Jonathan I. Silverberg   +12 more
doaj   +1 more source

Meta‐analysis of randomized clinical trials comparing clinical and patient‐reported outcomes between extra‐short (≤6 mm) and longer (≥10 mm) implants [PDF]

Journal of Clinical Periodontology, 2018
AbstractAimTo compare the clinical outcomes of ≤6 mm extra‐short implants (test group) versus ≥10 mm long implants (control group), with and without bone augmentation procedures.Materials and MethodsA systemic literature search of randomized clinical trials was performed using the PubMed (MEDLINE) and EMBASE databases.
Jordi Gargallo-Albiol, Jordi Gargallo-Albiol, Shayan Barootchi, Lorenzo Tavelli, I-Ching Wang, Andrea Ravidà, Houssam Askar, Hom-Lay Wang   +7 more
openaire   +3 more sources

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source

Use of IL‐1 β, IL‐6, TNF‐α, and MMP‐8 biomarkers to distinguish peri‐implant diseases: A systematic review and meta‐analysis [PDF]

Clinical Implant Dentistry and Related Research, 2018
AbstractObjectiveTo investigate the use of peri‐implant crevicular fluid (PICF) interleukin‐1β (IL‐1β), IL‐6, tumor necrosis factor‐α (TNF‐α), and matrix metalloproteinase‐8 (MMP‐8) biomarkers in distinguishing between healthy implants (H), peri‐implant mucositis (MU), and peri‐implantitis (PI).Material and MethodsElectronic using three databases ...
Iya Ghassib, Juanfang Zhu, Juanfang Zhu, Zhaozhao Chen, Zhaozhao Chen, Hom-Lay Wang   +5 more
openaire   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source