Results 101 to 110 of about 25,305,187 (391)

Sex‐Related Differences in Efficacy and Safety Outcomes in Axial Spondyloarthritis Randomized Clinical Trials: A Systematic Literature Review and Meta‐Analysis

open access: yesArthritis Care &Research, EarlyView.
Objective We aimed to assess differences in baseline characteristics, efficacy, and safety of advanced therapies between male and female patients with axial spondyloarthritis (axSpA) in randomized controlled trials (RCTs). Methods We conducted a systematic literature search for RCTs assessing the efficacy of advanced therapies in patients with axSpA ...
Angel Gao   +5 more
wiley   +1 more source

Towards causally interpretable meta-analysis: transporting inferences from multiple studies to a target population [PDF]

open access: yesarXiv, 2019
We take steps towards causally interpretable meta-analysis by describing methods for transporting causal inferences from a collection of randomized trials to a new target population, one-trial-at-a-time and pooling all trials. We discuss identifiability conditions for average treatment effects in the target population and provide identification results.
arxiv  

Simulation Models for Aggregated Data Meta-Analysis: Evaluation of Pooling Effect Sizes and Publication Biases [PDF]

open access: yesarXiv, 2020
Simulation studies are commonly used to evaluate the performance of newly developed meta-analysis methods. For methodology that is developed for an aggregated data meta-analysis, researchers often resort to simulation of the aggregated data directly, instead of simulating individual participant data from which the aggregated data would be calculated in
arxiv  

Accumulation Bias in Meta-Analysis: The Need to Consider Time in Error Control [PDF]

open access: yes, 2019
Studies accumulate over time and meta-analyses are mainly retrospective. These two characteristics introduce dependencies between the analysis time, at which a series of studies is up for meta-analysis, and results within the series. Dependencies introduce bias --- Accumulation Bias --- and invalidate the sampling distribution assumed for p-value tests,
arxiv   +1 more source

A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS IN THE TREATMENT OF BACTERIAL VAGINOSIS [PDF]

open access: yes, 2018
Introduction: Metronidazole is commonly used to treat bacterial vaginosis (BV) despite its various side effects and frequent cases of BV recurrences.
Darmayanti, A. T. (Aquartuti)   +2 more
core   +1 more source

Global Trends in Risk Factors for Low Back Pain: An Analysis of the Global Burden of Disease Study Data From 1990 to 2021

open access: yesArthritis Care &Research, EarlyView.
Objective The increasing burden associated with low back pain (LBP) is a critical issue. This is a novel analysis of trends in risk factors for LBP aiming to identify risk factors that require further attention or consideration in global policies to reduce the burden of LBP.
Katharine E. Roberts   +5 more
wiley   +1 more source

A Unified Method for Improved Inference in Random-effects Meta-analysis [PDF]

open access: yesarXiv, 2017
Random-effects meta-analyses have been widely applied in evidence synthesis for various types of medical studies. However, standard inference methods (e.g. restricted maximum likelihood estimation) usually underestimate statistical errors and possibly provide highly overconfident results under realistic situations; for instance, coverage probabilities ...
arxiv  

Placebo Effect Sizes in Clinical Trials of Knee Osteoarthritis Using Intra‐Articular Injections of Biologic Agents

open access: yesArthritis Care &Research, EarlyView.
Objective Patients with knee osteoarthritis rely on symptomatic treatments, in which up to 75% of the pain reduction can be attributed to the placebo effect. This effect may vary based on treatment type (eg, biologics vs nonbiologic injection) and route of administration (eg, intra‐articular vs topical vs oral).
Johanna M. Borst   +5 more
wiley   +1 more source

Beware the Meta-Analysis: Is Multiple Set Training Really Better than Single-Set Training for Muscle Hypertrophy? [PDF]

open access: yes, 2012
While many individuals perform resistance training with the purpose of increasing the size of their muscles, reviews have not clarified a training prescription for optimizing hypertrophy. A 2010 meta-analysis concluded that multiple set training resulted
Fisher, James
core   +1 more source

Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis.

open access: yesGastroenterology, 2017
BACKGROUND & AIMS The epidemiology of Helicobacter pylori infection has changed with improvements in sanitation and methods of eradication. We performed a systematic review and meta-analysis to evaluate changes in the global prevalence of H pylori ...
J. Hooi   +13 more
semanticscholar   +1 more source

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