Results 81 to 90 of about 50,179,594 (344)

Cytoreductive surgery (CRS) with hyperthermic intraoperative peritoneal chemotherapy (HIPEC) versus standard of care (SoC) in people with peritoneal metastases from colorectal, ovarian or gastric origin: protocol for a systematic review and individual participant data (IPD) meta-analyses of effectiveness and cost-effectiveness

BMJ Open, 2020
Introduction There is uncertainty about whether cytoreductive surgery (CRS)+hyperthermic intraoperative peritoneal chemotherapy (HIPEC) improves survival and/or quality of life compared with standard of care (SoC) in people with peritoneal metastases who
Brian R Davidson, Tim Mould, Kurinchi Gurusamy, Muntzer Mughal, Claire L Vale, R Bhanot, Mark Saunders, Omer Aziz, Sarah O'Dwyer   +8 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Gobernación del Meta

, 2023
Se desarrollan las actividades formativas realizadas en la Dirección departamental para la gestión del riesgo de desastres de la Gobernación del Meta durante el periodo 2023-1, donde se aplicaron los conocimientos obtenidos en el proceso formativo de la ...
Castillo Borbón, Marialicia
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Treatment options for women with heavy menstrual bleeding: a protocol for comprehensive systematic review, network meta-analyses and health economic assessment

BMJ Open
Introduction A quarter of women experience heavy periods in their lifetime, often significantly impairing their well-being, productivity and quality of life.Several treatment options are offered for heavy menstrual bleeding; however, there is limited ...
Rachael M Hunter, Ewelina Rogozinska, Claire L Vale, Khalid Saeed Khan, David J Fisher, Bassel H Al Wattar, Davor Jurkovic, Ngawai Moss, Jayne F Tierney, Ekaterina Bordea, Niccola Hutchinson-Pascal, Lily Nicholson   +11 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Estimation of novel coronavirus (COVID‐19) reproduction number and case fatality rate: A systematic review and meta‐analysis

Health Science Reports, 2021
Background and aims Realizing the transmission potential and the magnitude of the coronavirus disease 2019 (COVID‐19) aids public health monitoring, strategies, and preparation.
Tanvir Ahammed, Aniqua Anjum, Mohammad Meshbahur Rahman, Najmul Haider, Richard Kock, Md Jamal Uddin   +5 more
doaj   +1 more source

Informe de prácticas empresariales FENALCO seccional Meta y Llanos Orientales

, 2021
La seccional de Fenalco Meta cuenta con cinco áreas de trabajo, el área administrativa, el área de formación especializada, el área de coordinación de afiliados, el área de coordinación de eventos y, por último, el área comercial donde se encuentra el ...
Zamora Palomo, Andry Gimena
core  

Meta-analysis

, 2021
The sheer volume of available research and shifts toward evidence-based practice has led researchers and practitioners in sport and exercise psychology to rely increasingly on meta-analyses to summarize current knowledge, provide future research ...
Hagger, Martin
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source