Results 61 to 70 of about 17,266,935 (304)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Informe de práctica empresarial, Comisaría de Familia de Guamal

, 2023
Las Comisarías de Familia son la puerta de entrada para el acceso a la justicia que tienen las víctimas de violencia intrafamiliar, la cual conlleva de manera implícita la violación de los derechos humanos, repercute en el ámbito de la integridad física ...
Cárdenas Chaparro, Ingrid Julieth
core  

Treatment options for women with heavy menstrual bleeding: a protocol for comprehensive systematic review, network meta-analyses and health economic assessment

BMJ Open
Introduction A quarter of women experience heavy periods in their lifetime, often significantly impairing their well-being, productivity and quality of life.Several treatment options are offered for heavy menstrual bleeding; however, there is limited ...
Rachael M Hunter, Ewelina Rogozinska, Claire L Vale, Khalid Saeed Khan, David J Fisher, Bassel H Al Wattar, Davor Jurkovic, Ngawai Moss, Jayne F Tierney, Ekaterina Bordea, Niccola Hutchinson-Pascal, Lily Nicholson   +11 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

EVALUASI PENGEMBALIAN (RETUR) OBAT PADA SISTEM UNIT DOSE DISPENSING (UDD) DI INSTALASI FARMASI RAWAT INAP RS X

Sistem distribusi Unit Dose Dispensing (UDD) dapat menurunkan kesalahan pemberian obat hingga kurang dari 5%, dibandingkan dengan floor stock atau resep individu yang mencapai 18%. RS X merupakan rumah sakit yang telah menerapkan sistem UDD.
Amalia, Tisa, Azzahra, Fauzia, Haifa, Ayu Izzatin, Rahayu, Sri   +3 more
core   +1 more source

Network Meta-Analysis

, 2020
Network meta-analysis aims to compare multiple interventions by synthesizing studies where each study compares only some of the interventions. This chapter explains how direct and indirect evidence are synthesized to compare interventions linked in a ...
Nikolakopoulou, Adriani, Salanti, Georgia, Adriani Nikolakopoulou, Georgia Salanti, White, Ian R., Ian R. White   +5 more
core   +1 more source

Estimation of novel coronavirus (COVID‐19) reproduction number and case fatality rate: A systematic review and meta‐analysis

Health Science Reports, 2021
Background and aims Realizing the transmission potential and the magnitude of the coronavirus disease 2019 (COVID‐19) aids public health monitoring, strategies, and preparation.
Tanvir Ahammed, Aniqua Anjum, Mohammad Meshbahur Rahman, Najmul Haider, Richard Kock, Md Jamal Uddin   +5 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source